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    Psoriasis Patients Show Celiac Disease-associated Antibodies, No Correlation with HLA Cw6 Geneotype


    Jefferson Adams
    Image Caption: Journal of Clinical Laboratory Analysis celiac study

    Celiac.com 07/29/2010 - The underlying causes of psoriasis are not well understood. Many patients with psoriasis also have a sensitivity to gluten.


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    In an effort to better understand any connection between psoriasis, celiac disease, and the HLA Cw6 genotype, a research team examined the expression of celiac-associated antibodies gliadin IgA, gliadin IgG, and tissue transglutaminase IgA, and possible associations the antibodies may have with the HLA Cw6 gene in people with psoriasis.

    The team included Sangeeta Singh, Gyanendra Kumar Sonkar, Usha, and Sanjay Singh. They are variously affiliated with the Division of Immunopathology in the Department of Pathology at the Institute of Medical Sciences, the Department of Dermatology and Venereology, and the Academic Staff College at Banaras Hindu University in Varanasi, India.

    Antigens are substances that are recognized by the immune system and trigger an immune reaction.

    Class I human histocompatibility (HLA) antigens are coded into a small cluster of structural genes at the C locus on chromosome 6. They show substantially lower immune-triggering action than the HLA-A and -B determinants, and so are not a major factor in medical donations.

    Researchers find them useful because of their high-risk association with certain diseases, such as spondylarthritis, psoriasis, multiple myeloma. About 50 percent of all psoriasis patients carry HLC-Cw6.

    For the study the team evaluated 56 patients with psoriasis, along with 60 healthy control subjects. The team used ELISA to measure antibody levels, and the microcytotoxicity method to type HLA Cw6.

    Blood samples of psoriasis patients showed significant HLA Cw6 expression compared with control subjects (P
    Psoriasis patients showed substantially higher celiac-associated antibodies for gliadin IgA/IgG and tissue transglutaminase IgA compared with control subjects (P
    Women showed substantially higher serum anti-tissue transglutaminase IgA (anti tTG IgA) than did men. Older patients showed higher expressions than did their younger counterparts.

    Antibodies showed significant positive correlation (anti-gliadin IgA with anti-gliadin IgG: r=0.67, P.

    From their results, the team concludes that patients with psoriasis commonly show latent celiac disease or celiac-associated antibodies, but that HLA Cw6 is not connected with expression of these antibodies in patients with psoriasis.

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    Source:

    Dermatologic Therapy, Volume 23 Issue 2, Pages 155 - 159 - DOI: 10.1111/j.1529-8019.2010.01310.x

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    Source:
    J Invest Dermatol. 2011 Oct;131(10):2010-6. doi: 10.1038/jid.2011.162.

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    Sources:
    1. Toft M, Dietrichs E. Aggravated stuttering following subthalamic deep brain stimulation in Parkinson’s disease--two cases. BMC Neurol. 2011 Apr 8;11:44.
    2. Tani T, Sakai Y. Stuttering after right cerebellar infarction: a case study. J Fluency Disord. 2010 Jun;35(2):141-5. Epub 2010 Mar 15.
    3. Lundgren K, Helm-Estabrooks N, Klein R. Stuttering Following Acquired Brain Damage: A Review of the Literature. J Neurolinguistics. 2010 Sep 1;23(5):447-454.
    4. Jäncke L, Hänggi J, Steinmetz H. Morphological brain differences between adult stutterers and non-stutterers. BMC Neurol. 2004 Dec 10;4(1):23.
    5. Kell CA, Neumann K, von Kriegstein K, Posenenske C, von Gudenberg AW, Euler H, Giraud AL. How the brain repairs stuttering. Brain. 2009 Oct;132(Pt 10):2747-60. Epub 2009 Aug 26.
    6. Galantucci S, Tartaglia MC, Wilson SM, Henry ML, Filippi M, Agosta F, Dronkers NF, Henry RG, Ogar JM, Miller BL, Gorno-Tempini ML. White matter damage in primary progressive aphasias: a diffusion tensor tractography study. Brain. 2011 Jun 11.
    7. Lundgren K, Helm-Estabrooks N, Klein R. Stuttering Following Acquired Brain Damage: A Review of the Literature. J Neurolinguistics. 2010 Sep 1;23(5):447-454.
    8. [No authors listed] Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 43-1988. A 52-year-old man with persistent watery diarrhea and aphasia. N Engl J Med. 1988 Oct 27;319(17):1139-48
    9. Molteni N, Bardella MT, Baldassarri AR, Bianchi PA. Celiac disease associated with epilepsy and intracranial calcifications: report of two patients. Am J Gastroenterol. 1988 Sep;83(9):992-4.
    10. http://ezinearticles.com/?Food-Allergy-and-Stuttering-Link&id=1235725 
    11. http://www.craig.copperleife.com/health/stuttering_allergies.htm 
    12. https://www.celiac.com/forums/topic/73362-any-help-is-appreciated/
    13. Ford RP. The gluten syndrome: a neurological disease. Med Hypotheses. 2009 Sep;73(3):438-40. Epub 2009 Apr 29.
    14. Hadjivassiliou M, Gibson A, Davies-Jones GA, Lobo AJ, Stephenson TJ, Milford-Ward A. Does cryptic gluten sensitivity play a part in neurological illness? Lancet. 1996 Feb 10;347(8998):369-71.

    Jefferson Adams
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    Repeat biopsy showed that the clonal or PCP pattern persisted for up to 2 years with no evidence of RCDII. The study indicates that better understanding of clonal T cell receptor gene rearrangements may help researchers improve refractory celiac diagnosis. 
    Source:
    Journal of Clinical Pathologyhttp://dx.doi.org/10.1136/jclinpath-2018-205023

    Jefferson Adams
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    Source:
    Alimentary Pharmacology & Therapeutics

    Jefferson Adams
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    Source:
    Gut. 2017 Feb;66(2):250-257.  doi: 10.1136/gutjnl-2015-310148.