Celiac.com 10/12/2007 - The presence of gluten serves to activate HLA-DQ2/DQ8-restricted intestinal specific T-cells. Currently, the only treatment for celiac disease is a strict gluten-free diet. A team of Italian researchers recently conducted a study to determine whether a new enzyme strategy might offer promise in abolishing adverse gluten-associated activity.
They used biopsy specimens from 12 adults with known celiac disease to generate gliadin-specific intestinal T-cell lines (iTCLs), which they then challenged in vitro with various antigen solutions.
The results showed that tissue TG-mediated transamidation with lysine methylesther of P56-58, or gliadin in alkaline conditions inhibited the interferon expression in iTCLs.
Gastroenterology, Volume 133, Issue 3, September 2007; p780-789