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    Study Hints at Connection Between Celiac Disease and Certain Viral Infections


    Jefferson Adams

    Celiac.com 07/28/2016 - Celiac disease is an immune-mediated enteropathy triggered by gluten in genetically susceptible individuals. Researchers know that innate immunity plays a role in triggering celiac disease, but they don't understand the connection very well at all.


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    Although previous in vitro work suggests that gliadin peptide p31-43 acts as an innate immune trigger, the underlying pathways are unclear and have not been explored in vivo.

    The research team included RE Araya, MF Gomez Castro, P Carasi, JL McCarville, J Jury, AM Mowat, EF Verdu, and FG Chirdo. They are variously affiliated with the Instituto de Estudios Inmunológicos y Fisiopatológicos (IIFP)(CONICET-UNLP), Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Argentina; the Catedra de Microbiología, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Argentina; the Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada; the Centre for Immunobiology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, Scotland, United Kingdom; and with the Instituto de Estudios Inmunológicos y Fisiopatológicos (IIFP)(CONICET-UNLP), Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Argentina.

    Their team observed that introduction of p31-43 into the gut of normal mice causes structural changes in the small intestinal mucosa consistent with those seen in celiac disease, including increased cell death and expression of inflammatory mediators. The effects of p31-43 were dependent on MyD88 and type I IFNs, but not Toll-like receptor 4 (TLR4), and were enhanced by co-administration of the TLR3 agonist polyinosinic:polycytidylic acid.

    Together, these results indicate that gliadin peptide p31-43 activates celiac-related innate immune pathways in vivo, such as IFN-dependent inflammation.

    These findings also suggest a common mechanism for the potential interaction between dietary gluten and viral infections in the pathogenesis of celiac disease, meaning that certain viral infections may pave the way for celiac disease to develop.

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    Guest coloradosue

    Posted

    Duh!!!! My celiac disease was turned on when I was exposed to a virus my boss (he refused to stay home when he was running a fever and coughing violently) that had infected me and became double pneumonia. Once the virus had run it's course, in about two weeks, I had my first experience with celiac disease. My adult daughter 8 months later was diagnosed with celiac disease after exposure with a kidney infection. Her young son was diagnosed with celiac disease after exposure to bad virus. Definitely a pattern here!

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    Can a virus affect a "genetic" celiac diagnosis? If a genetic diagnosis is given does that mean both parents carry the gene at same time or only parent parent? Or is it a recessive gene from both parents. Or is this still unknown?

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    Guest Jess C

    Posted

    Can a virus affect a "genetic" celiac diagnosis? If a genetic diagnosis is given does that mean both parents carry the gene at same time or only parent parent? Or is it a recessive gene from both parents. Or is this still unknown?

    Immune system trauma from infections seems to be a common trigger of autoimmune diseases (like mine) according to my doctor. Genetic markers are unknown for most diseases so...

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    Guest Jess C

    Posted

    I have an autoimmune disease (not celiac) that directly coincided with probably the worst viral infection (strep) I've ever had. My doctors say they have no reason to speculate whether the infection triggered the autoimmune disease since treatments are the same and there's not much is known about possible triggers. It seems that compromised immune systems, no matter the severity or duration, are increasingly being linked to development of diseases. The biggest research hospitals say there's definitely a link but still don't know exactly how the process happens. It's easy to see that unhealthy people are more susceptible to infections and diseases. Think of: diabetics, smokers, alcoholics, obese, those exposed to toxins, etc.

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  • About Me

    Jefferson Adams is a freelance writer living in San Francisco. He has covered Health News for Examiner.com, and provided health and medical content for Sharecare.com. His work has appeared in Antioch Review, Blue Mesa Review, CALIBAN, Hayden's Ferry Review, Huffington Post, the Mississippi Review, and Slate, among others.

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    Jefferson Adams
    Celiac.com 03/30/2012 - A company called Microtest Laboratories is manufacturing doses of what they claim may be the first effective vaccine treatment for celiac disease. At this point, the only treatment for celiac disease is to avoid gluten in the diet.
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    Jefferson Adams
    Celiac.com 08/21/2015 - Here's every celiac disease treatment currently in development in a single list:
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    The group treated gluten-sensitive mice with elafin, a serine protease inhibitor, delivered by the L. lactis vector, and found normalization of inflammation, improved permeability, and maintained ZO-1 expression. There is speculation that this is due to reduced deamidation of gliadin peptide.
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    Source:
    Gastroenterology Report

    Jefferson Adams
    Celiac.com 07/27/2016 - Celiac disease is an immune-based disorder triggered by an adverse immune reaction to gluten proteins in genetically susceptible people. A new study shows that certain viral diseases may increase celiac risk, and confirms a link between intestinal viral infections and celiac disease.
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    Source:
    SCILOG

    Jefferson Adams
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    Jefferson Adams
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    Source:
    PLoS Med. 2018 Feb; 15(2): e1002507. doi:  10.1371/journal.pmed.1002507

    Jefferson Adams
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    Source:
    BMC Pediatrics

    Jefferson Adams
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    Stay tuned for more new on how the Theranos fraud story plays out.
    Read more at azcentral.com.