Jump to content
  • Sign Up
Celiac.com Sponsor:


Celiac.com Sponsor:


  • Join Our Community!

    Get help in our celiac / gluten-free forum.

  • Record is Archived

    This article is now archived and is closed to further replies.

    Scott Adams

    Celiac Disease Malignancy Risk Higher Despite Gluten-free Diet

    Scott Adams


    Reviewed and edited by a celiac disease expert.

    Am J Med. 2003 Aug 15;115(3):191-5



    Celiac.com Sponsor:




    Celiac.com 09/03/2003 - The results of a study conducted by Dr. Peter Green and colleagues at the College of Physicians and Surgeons in New York City indicate that, despite a gluten-free diet, people with celiac disease still have an elevated risk of getting non-Hodgkins lymphoma. The good news is that the risk of getting other types of cancers like small intestinal adenocarcinoma, esophageal cancer and melanoma were reduced in patients who adhered to a gluten-free diet, as was the overall risk of getting non-Hodgkins lymphoma. The study looked at 381 celiac disease patients, out of which 43 were diagnosed with cancer (11%). The vast majority—34—were diagnosed at or before their celiac disease diagnoses, so it is safe to say that they were not following a gluten-free diet.

    The results of this study emphasize the importance of adhering to a strict gluten-free diet, and of getting regular checkups by your doctor. Cancer screenings may also be advised, especially in cases where unexplained symptoms continue after going gluten-free. There is currently, however, no specific test for non-Hodgkins lymphoma, so one must learn about its warning signs and be on the lookout for any symptoms. - Scott Adams

    Here is the abstract of the study:

    Risk of malignancy in patients with celiac disease.

    Green PH, Fleischauer AT, Bhagat G, Goyal R, Jabri B, Neugut AI.

    Departments of Medicine (PHRG, RG, AIN), College of Physicians and Surgeons, New York, New York, USA

    Studies from Europe have demonstrated an increased risk of malignancy, especially non-Hodgkins lymphoma, in patients with celiac disease. However, there are no data on the risk for similar patients in the United States. Our aim was to estimate the risk of malignancy in a cohort of patients with celiac disease compared with the general U.S. population and to determine if a gluten-free diet is protective. Patients with celiac disease seen between July 1981 and January 2000 at a referral center were included. Standardized morbidity ratios (SMRs) (ratio of observed to expected) and corresponding 95% confidence intervals (CI) were calculated, using data from the National Cancer Institutes Surveillance, Epidemiology, and End Results Program. Forty-three (11%) of 381 celiac disease patients had a diagnosis of cancer; 9 were after the diagnosis of celiac disease, 7 were simultaneous (during same month of admission), and 27 were before the diagnosis. The standardized morbidity ratio for all cancers combined was 1.5 (95% CI: 0.3 to 7.5), with significantly increased values for small bowel cancer (SMR = 34; 95% CI: 24 to 42), esophageal cancer (SMR = 12; 95% CI: 6.5 to 21), non-Hodgkins lymphoma (SMR = 9.1; 95% CI: 4.7 to 13), and melanoma (SMR = 5.0; 95% CI: 2.1 to 12). Following the diagnosis of celiac disease, patients were at increased risk of non-Hodgkins lymphoma only (SMR = 6.2; 95% CI: 2.9 to 14), despite adherence to a gluten-free diet. The non-Hodgkins lymphoma included both T-cell and B-cell types and occurred in both gastrointestinal (n = 5) and extra intestinal sites (n = 4). In this cohort of patients with celiac disease, we observed increased risks of small intestinal adenocarcinoma, esophageal cancer, melanoma, and non-Hodgkins lymphoma. The risk of non-Hodgkins lymphoma persisted despite a gluten-free diet.


    User Feedback

    Recommended Comments

    This is great info on celiac disease as I was diagnosed with celiac and my mom died of esophagus cancer age 102 years so I should really be on the watch for that disease. Thank you.

    Share this comment


    Link to comment
    Share on other sites

    I am 37 years old and I was diagnosed with NHL two years ago. I have been in remission for a year. This month I was also diagnosed with Celiac disease. I feel like I finally found the answer I have been looking for for two years. Thank you.

    Share this comment


    Link to comment
    Share on other sites


    Guest
    This is now closed for further comments

  • About Me

    Celiac.com's Founder and CEO, Scott was diagnosed with celiac disease  in 1994, and, due to the nearly total lack of information available at that time, was forced to become an expert on the disease in order to recover. Scott launched the site that later became Celiac.com in 1995 "To help as many people as possible with celiac disease get diagnosed so they can begin to live happy, healthy gluten-free lives."  In 1998 he founded The Gluten-Free Mall which he sold in 2014. He is co-author of the book Cereal Killers, and founder and publisher of Journal of Gluten Sensitivity.

  • Related Articles

    Scott Adams
    Holmes GK, Prior P, Lane MR, Pope D, Allan RN
    Gut 1989 Mar;30(3):333-8
    Gastroenterology Unit, General Hospital, Birmingham.
    PMID: 2707633, UI: 89212172
    Two hundred and ten patients with coeliac disease previously reported from this unit were reviewed at the end of 1985 after a further 11 years of follow up. The initial review at the end of 1974 could not demonstrate...

    Jefferson Adams
    Celiac.com 09/17/2010 - People with celiac disease have higher risk for developing lymphoma and small bowel malignancy, though most studies have found no higher risk of colorectal cancer.
    To compare rates of colorectal cancer in celiac disease patients with rates for non-celiac disease control subjects, Dr. Peter Greene and colleagues at Columbia University Medical Center conducted...

    Jefferson Adams
    Celiac.com 02/28/2011 - Celiac disease is associated with an increased risk of lymphoma and small bowel malignancy. Colorectal cancer is the most common gastrointestinal cancers in the United States, but most studies have not found no higher rates of colorectal cancer for people with celiac disease, compared with rates in the general population.
    The results of these studies...

    Jefferson Adams
    Celiac.com 09/25/2013 - People with celiac disease have higher rates of lymphoproliferative malignancy. Currently, doctors just don't know whether risk levels are affected by the results of follow-up intestinal biopsy, performed to document mucosal healing.
    A team of researchers recently tried to find out if overall risk for lymphoproliferative malignancy in people with celiac...

  • Celiac.com Sponsor:

  • Forum Discussions

    Hi Fenrir - thank you for sharing your test results. This is very useful information. I’ll definitely ask for my numbers - with hindsight you’re probably right. My GP does have a tendency to say things are OK when sub-normal or just not prob...
    Not a good idea.  It would be safer and healthier food for you if brought your lunch to work.  It is much better to make your own food when starting the gluten-free diet so you know what is in it.  Trusting other people to make food safe fo...
    Hi, I have been made aware of this thread and I have formulated GliadinX in response to 2 of my children having been diagnosed with celiac disease about 8 years ago. Right of the bat, I would like to emphasize that even if there is a...
×
×
  • Create New...