Celiac.com 04/07/2009 - Idiopathic portal hypertension is a malady ofunknown cause, typically manifesting portal hypertension, splenomegalyand anemia secondary to hypersplenism.
Recently, a team ofIranian researchers encountered the case of a a 54-year-old maleadmitted for evaluation of malaise, weight loss, abdominal swelling andedema of the lower limbs.
The patient's clinicalevaluation showed pancytopenia, large ascites, splenomegaly andesophageal anomalies associated with portal hypertension.
Bloodtests and small intestinal biopsy showed the presence of celiacdisease. Patient's symptoms improved with a gluten-free diet, butimprovement was further impaired by ulcerative jejunoileitis, andintestinal T-cell lymphoma.
From these results, the researchersconclude that celiac disease, by means of a heightened immune responsein the splenoportal axis, can lead to the development of idiopathicportal hypertension in susceptible affected patients.
J Med Case Reports. 2009; 3: 68.