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  • Dr. Rodney Ford M.D.
    Dr. Rodney Ford M.D.

    Gluten Causes Brain Disease! By Prof. Rodney Ford M.B., B.S., M.D., F.R.A.C.P.


    This article appeared in the Autumn 2006 edition of Celiac.coms Scott-Free Newsletter.

    Celiac.com 12/11/2006 - Yes, thats what I think. Gluten-sensitivity is a disease of your brain and nerves.

    The gluten puzzle
    I have come to this conclusion after studying the effects of gluten on my patients for over a decade. I am a pediatric gastroenterologist and allergist. I run a busy clinic for children and their parents. I have been increasingly concerned by the large numbers of my patients who are affected by gluten. I was perplexed by their wide-ranging symptoms. The puzzle was to explain how gluten could cause so much ill health to so many people in so many different ways, including celiac disease.

    Faulty brain control
    Eureka! The solution came when deep in discussion with my friend and colleague, Ron Harper, Professor of Neurobiology, UCLA. We were both struggling with the concept of multiple symptoms that needed to be explained. The answer appeared absurdly simple: disturbed "brain control". It suddenly seemed obvious—gluten could disturb the neural pathways of the body. Gluten was gradually damaging the brain and the nerves of susceptible people. It was the brain that was the common pathway for the manifestations of all of the gluten symptoms. So I set out to research what the world medical literature had to say.

    Is gluten a neurotoxin?
    I felt excited. I reviewed my patients in this new light—I began looking for a brain-grain connection. I began to see gluten as a neurotoxin—this could provide a universal model of gluten-sensitivity. This toxicity might act through inflammatory mechanisms or cross-reactivity with neurons. I began accumulating the evidence for my proposal that gluten-sensitivity is a brain and nerve disease.

    "Full Of It!"
    The concept of "Full of it" developed from the stories from my patients. I wrote my hypothesis down in a book now called Full of it! It refers to our diets being full of gluten; to the world being full of gluten-sensitive people; to the medical practitioners who are so skeptical of adverse reactions to gluten; to the enthusiasm of people who are feeling vibrant again on a gluten-free diet; and to those who are brimming with hope that the problem of gluten has now been recognized.

    Food allergy skeptics
    As a junior doctor I decided to formally research the food allergy phenomenon. I was awarded a research post and carried out the first comprehensive food allergy studies in New Zealand. I triumphantly demonstrated that food allergy was both a real entity and that it was common. But, to my disappointment, my colleagues were reluctant to believe me or my data. They professed a "disbelief" in food allergy. This surprised me as I had the research data.

    My next step was to conduct four more years of investigation of food allergy in Australia (at the Royal Childrens Hospital, Melbourne). This was a bigger and more elaborate study. My Doctoral Thesis (1982) based on this work is called: Food hypersensitivity in children: diagnostic approaches to milk and egg hypersensitivity. Since then I have continued my investigations into food allergy—but still today (25 years later) medical skepticism abounds. This "disbelief" is held despite the vast body of research describing food allergy. There seems to be an underlying unwillingness for doctors to consider food allergy as a possibility. Unfortunately, this also applies to gluten reactions.

    The shocking truth
    The shocking truth about gluten is that gluten foods are causing tremendous damage—but currently this is going mostly unrecognized. Unfortunately, gluten grains have become our staple diet. The quantity of gluten in our food supply has been steadily increasing. Yet worse, official Health Policies endorse gluten grains as the foundation of our food pyramid.

    Medics turn a blind eye
    Gluten is sapping the energy and wellbeing of countless millions. To date, the medical profession has turned a blind eye to glutens wider problems whilst focusing all of their attention on the narrow problem of celiac disease.

    A typical story
    I received emails like this every day:

    "Dr Ford, I have emailed you a number of times regarding our two children.

    I thought I should let you know that since going gluten free for the last three months, at last our son and daughter have put on some weight.

    If I had kept them on a normal gluten diet (which they recommended at the hospital) we would be still be having the headaches and sore tummies as well as the bad moods which our son would have. People just thought he was a naughty child, but now he is so different - we can talk to him without getting into any fights.

    I congratulate you for all your efforts on bringing gluten intolerance to the media and medical profession. More children and their families may find long awaited help. We have had to put up with this for seven years! At long last there is light at the end of the tunnel. Kind regards, Sue and Garry."

    Can gluten damage your brain?
    I believe that gluten was actually causing these two children to be sick. That is the explanation for their "naughty" behavior, their moods and their headaches.

    I postulate that gluten can damage your brain. I have come to this conclusion by the abundant circumstantial evidence from my observations of my patients who are gluten-sensitive. I have pondered the next questions: "Why do they have such an array of symptoms from gluten?" "Why do they recover so quickly when gluten is removed?" And "Why do they deteriorate so rapidly when only tiny amounts of gluten are eaten?" The concept of a brain/nerve disease can explain everything.

    The brain/nerve hypothesis
    "The symptoms from gluten occur through its action on the nervous system".

    I propose that gluten-sensitivity is a brain condition. Each and every organ in your body has some form of brain/nerve control. I propose that gluten can injure the delicate nervous networks that control your guts functions. A malfunction will subsequently lead to all of the gut symptoms that have so well been described. In addition, gluten can also directly affect brain function, which leads to the primary neurological symptoms that are so commonly seen with gluten-sensitivity.

    What is new?
    There are a number of new ideas that I put forward. These are based on circumstantial evidence. They produce a unifying theory of the symptoms that are attributed to gluten toxicity.

    • A brain disease
      I consider that gluten-sensitivity is mostly a neurological problem. A major contribution to this debate is the realization that the brain has a central role in the expression of the symptoms that have, until now, been attributed to the local toxicity of gluten in the gut.
    • A nerve disease
      I propose that gluten-sensitivity is a nerve disease. There is a gigantic network of nerves that controls every function that your gut is programmed to do. There are as many nerve cells in your gut as there are in your head! (about 25 billion nerve cells). I call it your tummy brain (or gut brain). Your tummy brain can be directly damaged by gluten reactions. This is the cause of so many sore tummies and bowel troubles.
    • A wide spectrum of neurological manifestations
      For decades, there have been reports of unexplained brain and nerve symptoms which are associated with celiac disease. Although these associations have been described, there has been no universal mechanism proposed. However, if gluten is seen as a neurotoxin, then the explanation has been found.
    • A very common disease
      Reactions to gluten have recently been documented to be extremely common. About one-in-ten people (as ascertained by blood donor studies) have high levels of gluten antibodies in their blood. My clinical studies have arrived at this same high number of gluten-sensitive people. Others have data to show that it is even more prevalent.

    Am I full if it?
    You might ask, "Is he full of it?" Yes, I am full of excitement and hope for the future. So many people can now be helped, if only this information can be widely distributed. I am full of ideas and full of enthusiasm. I hope that you are full of hope for your healthy and vibrant future.

    Tariq's story:

    "Dear Rodney,


    Thank you for your care and support of my family in regard to our allergies, gluten sensitivity and celiac disease that exists within that framework.


    My son Tariq, who is nearly 12 years old, has been a patient of yours over a number of years for his multiple food allergies. Tariq also suffers from dyslexia. Over the last several years Tariq has been becoming increasingly tired, lacking in energy and motivation, struggling with school work and constantly scratching due to his eczema and rashes covering all of his body.

    During this time, even though he has attended soccer training up to four times a week he somehow gained a lot of weight. Tariq was constantly grumpy and had low mood levels.


    Two months ago you diagnosed Tariq with gluten-sensitivity (his tTG 4; IgG-gliadin 86; IgA-gliadin 9).

    Tariq was extremely reluctant to go on a gluten free diet. But as the rest of the family had gone gluten-free—so he was forced also to become gluten-free.

    The changes that a gluten-free diet has evoked in Tariq have been astounding. His energy levels have increased, his skin has vastly improved, he has lost a lot of his excess weight (even though his appetite has increased) and he has shown improvement in his dyslexia.

    Tariq is not as grumpy as he was and his mood levels have improved. Tariq is now vigilant about gluten and can see the differences it has made to his life and the quality of it.

    Also, the other soccer parents have noticed a vast improvement in Tariqs energy levels and speed. His teacher has also noticed a big difference.

    Thanks again.

    Regards, Rosemary"

    Are you affected?
    The shocking truth is that gluten can damage your brain and that so many people are being encouraged to eat gluten-foods that might be steadily eroding their health and energy. If you have any lingering doubt about your own health, then I suggest that you check out the possibility of gluten-sensitivity.

    If you have any comments or questions we would love to hear from you.

    Dr Rodney Ford is a Pediatric Gastroenterologist, Allergist and Nutrition Consultant. He has been Associate Professor of Pediatrics at the Christchurch School of Medicine, University of Otago. He runs a busy Childrens Gastroenterology and Allergy Clinic in Christchurch, New Zealand. He has written over a hundred scientific papers including book chapters and books. www.doctorgluten.com

    This includes a series of five books on gluten: why it can make you ill and how to go gluten-free.

    • Are You Gluten-Sensitive? Your Questions Answered
    • Going Gluten-Free: How to Get Started
    • The Gluten-Free lunch book
    • The book for the Sick, Tired and Grumpy (Gluten-Free kids)
    • Full of it! The shocking truth about gluten (The brain-grain connection - ISBN 978-0-473-10407-8)

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    Guest Waller McInnes

    Posted

    I am 5 days gluten free and for the first time in my life I can see straight!!!

    For 10 years, I was bulimic, and then so-called anorexic, despite eating as much as possible. I constantly felt as if I was being attacked when I sat down to eat. I was depressed, angry, anxious and could barely smile.

    I have been studying the healing properties of food for many years, every day struggling to find foods that agreed with my system. The one glutenous food I was hanging onto was shoyu soy sauce, and now that I have given it up, the pain in my body, diabetic and epileptic symptoms are diminishing, my body is registering the food it is taking in and the anxiety is greatly reduced!

    I am so excited about what lies ahead. Thank you for sharing this powerful article. I know for sure the gluten sensitivity and possible celiac caused me 27 years of severe angst--the word needs to get out there BIG TIME!

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    I was diagnosed at 50, my son at 40. I was a nervous teen and could not read aloud in front of my class and knew the fear and self consciousness was not normal even though I was told that I was a beautiful girl. My son in his teens became ill and hard to get along with hot tempered and stressed. He developed neuropathy and diagnosed without stomach problems. My sister lives in a small town with nerve problems, diabetes and now stomach problems. Her doctors won't test her for Celiac. You are right!

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    Animal feed has soy and gluten containing grains, the reason it is better to buy 100 percent grass fed beef and wild fish and raw organic butter made from 100 percent grass fed cattle.

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    Please tell everyone about this. I was recently diagnosed after years of being misdiagnosed. Now my body has so much damage done they don't know how soon I'll begin to feel well. I am glad that I know what is wrong now, but I do feel angry that years of my life have been stolen because of the incredible lack of knowledge about this disease.

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    I can vouch for this, I have had mental problems since the age of ten (am now sixty three) and only discovered gluten to be the problem two years ago.

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    I can vouch for this, I have had mental problems since the age of ten (am now sixty three) and only discovered gluten to be the problem two years ago.

    My heart goes out to you! I am grateful for what you wrote here Tony, because you got me thinking that maybe my aunt (my mom's sister) who had mental illness (now deceased) could of had celiac disease. Then there is my sister who's dealing with mental illness and living on the streets of CA :( and wants no help for anyone. Then when I think of my mom I see that she is a little bit off and could never drink milk and has other symptoms the fit celiac disease. Her mom and other members on her side too had problems of mental illness. Sadly so far I am the only one that was diagnosed with celiac disease back in 1996 and didn't know until a week ago how serious this celiac disease is because the doctor didn't tell me. UGH!!!!! I been told I have Fibromyalgia, Lupus, Arthritis...and the list goes on. No mention from my new doctor about celiac disease, I will bring it up next month when I see him that should be interesting, since he has my 1996 results in his file and never once mentioned the celiac disease just other things they found with me like mono. You really got me thinking that all along with my mom's side of the family it's just been celiac disease! Thanks again!

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    My heart goes out to you! I am grateful for what you wrote here Tony, because you got me thinking that maybe my aunt (my mom's sister) who had mental illness (now deceased) could of had celiac disease. Then there is my sister who's dealing with mental illness and living on the streets of CA :( and wants no help for anyone. Then when I think of my mom I see that she is a little bit off and could never drink milk and has other symptoms the fit celiac disease. Her mom and other members on her side too had problems of mental illness. Sadly so far I am the only one that was diagnosed with celiac disease back in 1996 and didn't know until a week ago how serious this celiac disease is because the doctor didn't tell me. UGH!!!!! I been told I have Fibromyalgia, Lupus, Arthritis...and the list goes on. No mention from my new doctor about celiac disease, I will bring it up next month when I see him that should be interesting, since he has my 1996 results in his file and never once mentioned the celiac disease just other things they found with me like mono. You really got me thinking that all along with my mom's side of the family it's just been celiac disease! Thanks again!

    Hi Shelly

    Thank you, and thanks to everyone else for your insightful comments. The more I look at the evidence of gluten and neurological harm, the more I am concerned to leave children eating gluten if they are susceptible to gluten reactivity. I have the privilege of being invited to speak at a number of cities in the USA in Oct/Nov this year (2009). The topic is: “The Gluten Syndrome: a neurological diseaseâ€. See link: http://www.csaceliacs.org/Conferences/2009Presenters.php

    This is a huge subject, and a very worrying one. Again I appreciate the support and interest of the group. Cheers, Dr Rodney Ford.

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    I just found out that I have celiac disease but my GI doctor isn't convinced that it is true so I had to go through all of his tests because I am have hepititus as well. I've been on the gluten free diet for a week and see a very pronounced change. I thought I had low sugar because of a fainting spell at work and severe cramps in my legs. Yes I agree that this stuff IS a toxin and it has an effect on the brain as well as the rest of the body.

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    Doctor,

     

    The missing piece of this puzzle is gluten ---> glutamate release. Wheat in particular is full of other glutamate precursors, not just gluten.

     

    Glutamate excitotoxicity (like toxicity from monosodium glutamate ingestion) ---> acetylcholine release ---> histamine ---> inflammation. Brain fog, autoimmune issues, and more will crop up along any step of these pathways. The process is seen pretty clearly in asthma, where magnesium (directly antagonizes glutamate/CA++ overflow) is given intravenously in dangerous attacks, causing rapid bronchodilation.

     

    Glutamate excitotoxicity ---> prolactin release ---> dopamine antagonism.

     

    etc.

     

    Good luck!

    Can you explain the asthma/magnesium connection in more lay terms. I have gluten problems (deep sleeps) but also bronchial asthma. I have been taking magnesium for the heart palpitations I get after eating wheat or yeast. Should I stop ?

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  • About Me

    Dr. Rodney Ford is a Pediatric Gastroenterologist. He was Professor of Pediatrics at the Christchurch School of Medicine. He runs the Children's Gastroenterology and Allergy Clinic in New Zealand. He has written a series of 7 books on gluten (www.DrRodneyFord.com). His main theory is that symptoms from gluten reactions arise from brain and nerve damage. His latest book is "The Gluten Syndrome" which encapsulates current ideas and concepts of gluten and the harm that it does.

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