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  • Jefferson Adams
    Jefferson Adams

    Connection Found between Celiac Disease and Hashimoto's Thyroiditis

    Reviewed and edited by a celiac disease expert.

    Celiac.com 04/23/2007 - The results of a recent Dutch study published in the World Journal of Gastroenterology have confirmed a connection between Hashimotos Thyroiditis and celiac disease.

    In the study, 104 individuals with Hashimotos Thyroiditis were tested for immunoglobulin A anti-transglutaminase (tTG) antibodies, IgA anti-endomysial antibodies (EMA) and HLA-DQ typing. Those who tested positive for any of the serological tests were given an intestinal biopsy.

    Sixteen patients (15%) showed positive celiac serology and five patients clear villous atrophy were diagnosed with celiac disease (4.8%; 95% CI 0.7-8.9). All five patients diagnosed with celiac disease, and 53 patients with Hashimotos thyroiditis (50%; 95% CI 43-62), showed the presence of HLA-DQ2 (and/or -DQ8).

    In a separate test within the study, 184 Individuals with known celiac disease were given a serological test for thyroglobulin and thyroid peroxidase Antibodies, after first being given thyroid biochemical, a thyroxine-free thyroid stimulating hormone.

    39 patients (21%) showed positive thyroid serology. According to thyroid biochemistry results, ten patients showed euthyroidism (5%; 95% CI 2-9), seven showed sub-clinical hypothyroidism (3.8%; 95% CI 1.8-7.6), and 22 patients showed overt hypothyroidism, Hashimotos thyroiditis (12%; 95% CI 8-16). Furthermore, four patients with celiac disease had Graves disease (2%; 95% CI 0.8-5) and one patient had post-partum thyroiditis.

    The study concludes that there is a clear association between Hashimotos thyroiditis and celiac disease. Accordingly, it is recommended that patients with Hashimotos thyroiditis be screened for celiac disease and that patients with known celiac be screened for Hashimotos thyroiditis.

    World Journal of Gastroenterology 2007; 13(10).

    health writer who lives in San Francisco and is a frequent author of articles for Celiac.com.

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    Wow....I am blown away by what I am reading. Thank you Jesus I apparently am not crazy thanks to what I am reading from these posts. I am 42 years old and have been diagnosed with IBS and Hashimoto's. I suspected early that these two were somehow related but was told by Mayo clinic in Jacksonville that they are not. And was also told two weeks ago by my endocrinologist that they are not related. I believe now and have believed for a while that they are indeed related and I think now that I have celiac instead of IBS. I have started a gluten free diet to hopefully help with this constant diarrhea, stomach cramping, and bloating. Thank you all for helping me not feel so alone. This has been a nightmare since last October. Take care everyone and thanks again for your comments.

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    My doctor is giving a second blood test to my 10 year old daughter who the 1st blood test and a doctor's exam of her thyroid for possible Hashimoto's, and there is celiac in my family as well as gluten sensitivity, allergies etc . I too feel that Hashimo's too should be treated by treating what is causing it as well....if 2nd tests are also conclusive for Hashimoto's we are going gluten-free and with thyroid meds maybe she will be able to reverse the Hashimoto's, as she is only 10! There is also a high correlation between thyroid cancer and Hashimoto's, so I believe getting gluten free is the answer for everyone...celiac or not....of course we take B12 and regular multivitamins as well .....the food and all the genetic modifiers are the reason as well as the increase in cancer ...my opinion!

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  • About Me

    Jefferson Adams is Celiac.com's senior writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University, and has authored more than 2,000 articles on celiac disease. His coursework includes studies in science, scientific methodology, biology, anatomy, medicine, logic, and advanced research. He previously served as SF Health News Examiner for Examiner.com, and devised health and medical content for Sharecare.com. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of the book "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.

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