Jump to content
  • Sign Up
Celiac.com Sponsor:

Celiac.com Sponsor:

  • Join Our Community!

    Get help in our celiac / gluten-free forum.

  • Jefferson Adams

    Could Gluten-Sensitivity Play a Role in Acute Mania?

    Jefferson Adams

    Reviewed and edited by a celiac disease expert.

      The team found that patients with mania had significantly higher levels of IgG antibodies to gliadin at baseline.

    Caption: Artistic view of how the world feels like with schizophrenia. Image: CC0 1.0--Yeenosaurus

    Celiac.com 08/05/2019 - The relationship between mental health, gluten sensitivity, and celiac disease has not been well researched. Some studies have shown that people with schizophrenia and bipolar disorder have elevated levels of antibodies to gliadin.

    A team of researchers recently set out to examine longitudinally the levels of antibody reactivity to gliadin in acute mania. The sample included 60 individuals assessed during a hospital stay for acute mania, 39 at a 6-month follow-up, and a sample of 143 non-psychiatric control subjects. 

    Celiac.com Sponsor:

    The research team included Faith Dickerson, Cassie Stallings, Andrea Origoni, Crystal Vaughan, Sunil Khushalani, and Robert Yolken. They are variously affiliated with the Stanley Research Program at Sheppard Pratt, Baltimore, MD, USA, and the Stanley Neurovirology Laboratory, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD, USA. 

    The team used enzyme immunoassay to measure antibodies to gliadin. They used regression models to analyze the relationship between the antibodies and the clinical progress of patients with mania. 

    Using multivariate analyses, the team found that patients with mania had significantly higher levels of IgG antibodies to gliadin at baseline, but not other markers of celiac disease, compared with control subjects. 

    At the six month follow-up, however, these levels did not differ substantially from those of control subjects. 

    In patients with mania, elevated levels after six months were strongly associated with re-hospitalization in the 6-month follow-up period. 

    Based on these results, the team concludes that the monitoring and control of gluten sensitivity could be helpful in managing individuals hospitalized with acute mania.

    Stay tuned for more on this and related stories.


    User Feedback

    Recommended Comments

    Could Gluten-Sensitivity Play a Role in Acute Mania? My answer is yes. What qualify me to give that answer? My own experience and reading other experiences plus the studies out there. There should be no doubts that the damage that gluten causes affect the brain by direct or indirect way. Once gluten cause a leaky gut there is not telling what is going to happen until its happen. 

    Share this comment

    Link to comment
    Share on other sites

    Join the conversation

    You are posting as a guest. If you have an account, sign in now to post with your account.
    Note: Your post will require moderator approval before it will be visible.

    Add a comment...

    ×   Pasted as rich text.   Paste as plain text instead

      Only 75 emoji are allowed.

    ×   Your link has been automatically embedded.   Display as a link instead

    ×   Your previous content has been restored.   Clear editor

    ×   You cannot paste images directly. Upload or insert images from URL.

  • About Me

    Jefferson Adams is Celiac.com's senior writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University, and has authored more than 2,500 articles on celiac disease. His coursework includes studies in science, scientific methodology, biology, anatomy, medicine, logic, and advanced research. He previously served as SF Health News Examiner for Examiner.com, and devised health and medical content for Sharecare.com. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of the book "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.

  • Related Articles

    Jefferson Adams
    Celiac.com 04/29/2009 - A team of researchers based at UK's prospective University of Highlands and Islands (UHI) have found a link between gluten and schizophrenia. According to their latest findings, proteins found in the gluten of wheat, rye and barley might play a role in triggering schizophrenia in people with a genetic risk for the condition, or in worsening symptoms in people...

    Jefferson Adams
    Celiac.com 01/23/2013 - Can going gluten-free bring about a major improvement in mental health for some children?
    This question is addressed in recent article by Mary Lochner. In the article, Lochner talks about the challenges she faced in trying to raise her daughter who, for the first couple of years, seemed to become more and more emotionally volatile and unstable, even ...

    Jefferson Adams
    Celiac.com 12/08/2014 - Many people with celiac disease report suffering from impaired cognition or "brain fog," but no good study had been done until a research team took an in-depth look at the issue. Of particular interest was the degree to which improved mental clarity in gluten-free celiac patients correlates with histological and serological measures of disease severity.

    Jefferson Adams
    04/22/2019 - A gluten-free diet can improve symptoms of schizophrenia in certain patients, new research suggests. In the small pilot study, Deanna L. Kelly, PharmD, professor of psychiatry, University of Maryland School of Medicine, Baltimore, and colleagues studied the effects a gluten-free diet in schizophrenia, especially in patients with elevated gluten antibodies.

  • Create New...