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  • Jefferson Adams
    Jefferson Adams

    Could Gluten-Sensitivity Play a Role in Acute Mania?

    Reviewed and edited by a celiac disease expert.

      The team found that patients with mania had significantly higher levels of IgG antibodies to gliadin at baseline.

    Caption: Artistic view of how the world feels like with schizophrenia. Image: CC0 1.0--Yeenosaurus

    Celiac.com 08/05/2019 - The relationship between mental health, gluten sensitivity, and celiac disease has not been well researched. Some studies have shown that people with schizophrenia and bipolar disorder have elevated levels of antibodies to gliadin.

    A team of researchers recently set out to examine longitudinally the levels of antibody reactivity to gliadin in acute mania. The sample included 60 individuals assessed during a hospital stay for acute mania, 39 at a 6-month follow-up, and a sample of 143 non-psychiatric control subjects. 

    The research team included Faith Dickerson, Cassie Stallings, Andrea Origoni, Crystal Vaughan, Sunil Khushalani, and Robert Yolken. They are variously affiliated with the Stanley Research Program at Sheppard Pratt, Baltimore, MD, USA, and the Stanley Neurovirology Laboratory, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD, USA. 

    The team used enzyme immunoassay to measure antibodies to gliadin. They used regression models to analyze the relationship between the antibodies and the clinical progress of patients with mania. 

    Using multivariate analyses, the team found that patients with mania had significantly higher levels of IgG antibodies to gliadin at baseline, but not other markers of celiac disease, compared with control subjects. 

    At the six month follow-up, however, these levels did not differ substantially from those of control subjects. 

    In patients with mania, elevated levels after six months were strongly associated with re-hospitalization in the 6-month follow-up period. 

    Based on these results, the team concludes that the monitoring and control of gluten sensitivity could be helpful in managing individuals hospitalized with acute mania.

    Stay tuned for more on this and related stories.


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    Could Gluten-Sensitivity Play a Role in Acute Mania? My answer is yes. What qualify me to give that answer? My own experience and reading other experiences plus the studies out there. There should be no doubts that the damage that gluten causes affect the brain by direct or indirect way. Once gluten cause a leaky gut there is not telling what is going to happen until its happen. 

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  • About Me

    Jefferson Adams is Celiac.com's senior writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University, and has authored more than 2,000 articles on celiac disease. His coursework includes studies in biology, anatomy, medicine, science, and advanced research, and scientific methods. He previously served as SF Health News Examiner for Examiner.com, and devised health and medical content for Sharecare.com. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of the book "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.

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