Jump to content
  • Sign Up
Celiac.com Sponsor:


Celiac.com Sponsor:


  • Join Our Community!

    Get help in our celiac / gluten-free forum.

  • Jefferson Adams

    Does Gluten Play a Role in the Onset of Type 1 Diabetes?

    Jefferson Adams


    Reviewed and edited by a celiac disease expert.

      Children with type 1 diabetes who ate a gluten-free diet for their first year after diagnosis needed less insulin, among other findings.


    Caption: Image: CC--wuestenigel

    Celiac.com 07/04/2019 - There's been some data to suggest that gluten may play a role in diabetes, but there really isn't much data on the role of gluten in type 1 diabetes (T1D), so a team of researchers recently set out to test whether gluten plays a role in type 1 diabetes onset. Specifically, the team wanted to know if a gluten-free diet can decelerate the decline in beta-cell capacity in newly diagnosed non-celiac children with T1D.

    The research team included Vít Neuman, Stepanka Pruhova, Michal Kulich, Stanislava Kolouskova, Jan Vosahlo, Martina Romanova, Lenka Petruzelkova, Barbora Obermannova, Ondrej Cinek, and Zdeněk Šumník. They are variously affiliated with Charles University in Prague, and the University of Chemistry and Technology in Prague, Czech Republic.



    Celiac.com Sponsor:




    For their non-randomized self-selected intervention trial, the team recruited forty-six children, from about 6-13 years old. One group of 26 began a gluten-free diet, while 20 continued on a standard non-gluten-free diet. 

    Main outcomes were the decline in C-peptide area under the curve (AUC) in mixed-meal tolerance tests and the differences in insulin dose, insulin dose adjusted A1c (IDAA1c) and HbA1c at 12 months. 

    Data were analyzed as intention-to-treat by linear regression models adjusted for baseline parameters. The adherence to a gluten-free diet was tested by immunoreactive gluten in stool.

    Average decrease in C-peptide AUC was 293 vs.484 pmol/L (p=0.3) at 6 months, and 567 vs. 919 pmol/L (p=0.1) at 12 months in the gluten-free diet and control group, respectively. 

    The group that ate a gluten-free diet had a lower insulin dose by 0.22 U/kg/day, lower IDAA1c by 1.5, and lower average HbA1c by 7.5 mmol/mol (p=0.01) after 12 months. Daily carbohydrate intake between the groups was the same. Researchers found immunoreactive gluten in the stool of just 3 patients.

    Children with type 1 diabetes who ate a gluten-free diet for their first year after diagnosis lower insulin demand and lower HbA1c, although C-peptide dynamics were similar for each group.

    This is the first study to provide solid data on the connection between gluten intake and type 1 diabetes. The fact that children who follow a gluten-free diet need less insulin is intriguing.

    Read more at Diabetes 2019 Jun; 68(Supplement 1).


    User Feedback

    Recommended Comments

    It is well known in the diabetes community that there is often a "honeymoon period" during the first year after diagnosis in children where insulin needs are less. I am curious how they were able to determine that the decreased insulin requirements were due to a gluten free diet vs. this well accepted fact when the C-peptide levels were similar in both groups. 

    Share this comment


    Link to comment
    Share on other sites


    Join the conversation

    You are posting as a guest. If you have an account, sign in now to post with your account.
    Note: Your post will require moderator approval before it will be visible.

    Guest
    Add a comment...

    ×   Pasted as rich text.   Paste as plain text instead

      Only 75 emoji are allowed.

    ×   Your link has been automatically embedded.   Display as a link instead

    ×   Your previous content has been restored.   Clear editor

    ×   You cannot paste images directly. Upload or insert images from URL.


  • About Me

    Jefferson Adams is Celiac.com's senior writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University, and has authored more than 2,500 articles on celiac disease. His coursework includes studies in science, scientific methodology, biology, anatomy, medicine, logic, and advanced research. He previously served as SF Health News Examiner for Examiner.com, and devised health and medical content for Sharecare.com. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of the book "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.

  • Related Articles

    Jefferson Adams
    Celiac.com 11/21/2011 - Celiac disease is common in people with type 1 diabetes (T1D). These people can show Abs reactions against tissue transglutaminase, the prime trigger in celiac disease. In short, gliadin seems to play a role in type 1 diabetes pathogenesis.
    An international research team set out to investigate whether gliadin contributes to enteropathy and insulitis...

    Jefferson Adams
    Celiac.com 02/22/2017 - Type 1 diabetes mellitus (T1DM) and celiac disease (celiac disease) are autoimmune diseases that share similar genetic patterns. T1DM treatment is based on diet, physical activity and insulin therapy, whereas celiac disease treatment is based on a gluten-free diet.
    A research team recently set out to evaluate the quality of life (QoL) of individuals with...

    Dr. Vikki Petersen D.C, C.C.N
    Celiac.com 10/27/2017 - It has long been understood that two autoimmune diseases, celiac disease and type 1 diabetes are related. They share common genes and the incidence of celiac disease is higher among type 1 diabetics. There have been some anecdotal reports regarding children diagnosed with type 1 diabetes who were put on a gluten-free diet soon after their diagnosis and for...

    Jefferson Adams
    Celiac.com 10/19/2018 - Work to develop a vaccine for celiac disease could soon lead to a vaccine for diabetes.
    After successful phase 1 studies of Nexvax2, their peptide-based therapeutic vaccine for celiac disease, ImmusanT has seen a significant investment from venture philanthropy organization JDRF T1D. ImmusanT's peptide therapy program for celiac disease may provide...

  • Celiac.com Sponsor:

  • Forum Discussions

    CB, sorry to hear you're still having problems.  Deficiency of Vitamin B12 can cause diarrhea.  It's a frequently overlooked symptom.  Did you discuss with your doctor what to do about the B12 deficiency? Shots or oral supplements?  ...
    I think you should consider getting tested for celiac disease in order to help rule out gluten ataxia.  Why?  I just had anemia.  No GI issues with gluten.  I never would have guessed that I had celiac disease.  
    My mom has Graves.  I much prefer Hashimoto’s!  I had a few thyroid swings and it is easier to be hypo than hyper.  My Mom has permanent eye damage as a result.  If you have Graves, get treatment which may include surgery.  Her ferritin levels a...
×
×
  • Create New...