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  • Jefferson Adams
    Jefferson Adams

    Early Pregnancy Loss in Celiac Women: The Role of Genetic Markers of Thrombophilia

    Reviewed and edited by a celiac disease expert.

    10/05/2009 - Pregnant women with celiac disease suffer early pregnancy loss more often than women without celiac disease. A team of Italian researchers recently set out to look at a possible role of genetic pro-thrombotic variants in early pregnancy loss in women with celiac disease.

    The research team was made up of C. Ciacci, R. Tortora, O. Scudiero, R. Di Fiore, F. Salvatore, and G. Castaldo. The team looked at 39 women with celiac disease, who had experienced at least two early pregnancy losses within the first 3 months of pregnancy, a control group of 72 celiac women with a history of one or more normal pregnancies with no pregnancy loss.

    Each of the women were enrolled in the study immediately upon diagnosis for celiac disease, whereupon, the researchers obtained a clinical history obtained from each woman.

    The researchers then screened leukocyte DNA for factor V Leiden (mutation G1691A), factor V R2 (H1299R), factor II (G20210A), methylenetetrahydrofolate reductase
    (MTHFR) (C677T and A1298C), beta-fibrinogen (−455 G>A), PAI-1 alleles 4G/5G, factor XIII (V34L), and HPA-1 (L33P).

    Women with pregnancy losses were notably older (p = 0.002) among the celiacs than in controls. Of the gene variants examined, the allelic frequency of 4G variant of PAI-1, and the frequency of mutant genotypes were significantly more frequent in the group of celiac women with early pregnancy loss (p = 0.00003 and 0.028, respectively).

    Interestingly, the beta-fibrinogen −455 G>A genotype distribution differs substantially between the two groups, though frequency of the variant allele remains the same. The control group showed more frequent variant genotypes (p = 0.009).

    Based on these data, the research team believes the 4G variant of the PAI-I gene may predispose some celiac women who carry the gene to early pregnancy loss, though they note that their data should be confirmed on larger populations.


    Digestive and Liver DiseaseVolume 41, Issue 10, October 2009, Pages 717-720


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    Guest Elizabeth Belfiore

    Posted

    I had 2 premature births in my 20's & 30's. I am 62 & was

    diagnosed with celiac at 51. First premature ended after 36 hours and second one my daughter is now 31 years of age.

    She was born at the beginning of the 7 month and weighed

    2lbs 13ozs.

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    I have 2 comments:

    1. Thank you for summarizing peer reviewed journal articles related to celiac disease! I appreciate hearing about the latest research and your articles always prompt me to look further, and obtain the full article if possible!

     

    2. I think you should make an important distinction in the 5th paragraph of your article. As I interpret the research article, the researchers noted a significant difference in age of diagnosis between the two groups, not age at which the pregnancy loss occurred. This does not come across as currently stated in your summary, and I think it is a critical point!

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    I totally agree with Marcia! I am 30 years old and was diagnosed a year ago with celiac. We have been trying to conceive for a year and a half now and I just had my first miscarriage and I would like more information on the connection between celiac and miscarriages and problems with conception. I read that once our bodies heal that it would become easier but it's been almost a year since my diagnosis.

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    Article a little hard to understand for the average person but still helpful. My story short and sweet. Started trying to get pregnant after marriage at 35. 8 pregnancies..3 births. All miscarriages around 11-14 weeks. After last baby was born which was 4 years ago I was so tired, so tired of looking pregnant all the time and always having stomach troubles. Was diagnosed with celiac disease in February of 2013.

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  • About Me

    Jefferson Adams is Celiac.com's senior writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University, and has authored more than 2,000 articles on celiac disease. His coursework includes studies in science, scientific methodology, biology, anatomy, medicine, logic, and advanced research. He previously served as SF Health News Examiner for Examiner.com, and devised health and medical content for Sharecare.com. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of the book "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.

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