Jump to content
  • Sign Up
Celiac.com Sponsor:


Celiac.com Sponsor:

  • Join Our Community!

    Get help in our celiac / gluten-free forum.

  • Jefferson Adams
    Jefferson Adams

    Gluten Influences Gut Microbial Activity in People Without Celiac Disease

    Reviewed and edited by a celiac disease expert.

    Celiac.com 02/24/2014 - What kind of impact does gluten have in on the microbial gut activity of healthy people without celiac disease? A team of researchers set out to answer that question by studying the metabolism of gluten in healthy individuals, and the effects of gluten on their intestinal microbial activity.

    Photo: CC--Hans DekkerThe research team included A. Caminero, E. Nistal, L. Arias, S. Vivas, I. Comino, A. Real, C. Sousa, J.M. de Morales, M.A. Ferrero, L.B. Rodríguez-Aparicio, and J. Casqueiro, all with the Área de Microbiología at the Universidad de León in León, Spain.


    Celiac.com Sponsor:



    The team analyzed fecal samples from eleven healthy subjects under four different diet regimens: a normal gluten diet, a strict gluten-free diet (GFD), a GFD with a supplemental intake of 9 g gluten/day and a GFD with a supplemental intake of 30 g gluten/day.

    In each case, they measured gluten content, fecal tryptic activity (FTA), short-chain fatty acids (SCFAs) and fecal glutenasic activity (FGA). Fecal gluten contents, FTA, SCFAs and FGA varied sharply, according to levels of dietary gluten intake.

    When patients received high gluten doses, over 30 grams per day, they showed sharply higher SCFA concentrations of around 70.5 mmoles per kg of feces, compared with concentrations of around 33.8 mmoles per kg feces during the gluten-free phase of the experiment.

    However, the FTA showed significant differences between the GFD (34 units) and the normal gluten-containing diet (60 units), and also between the GFD and the GFD + 30 g of gluten/day (67 units).

    In every case, when patients regularly consumed gluten, gluten was detected in the feces. This demonstrates that at least a portion of the ingested gluten is eliminated in the large intestine, thus offering a substrate for intestinal microbial proteases.

    The results also showed that fecal glutenasic activity increased proportionally with dietary gluten, showing an enzymatic activity of 993 units in DSG, 2,063 units in DSG + 9 g and 6,090 units in DSG + 30 g.

    Gluten consumption definitely influences the activity of intestinal microbes, and also increases gluten proteolytic activity in the feces of healthy, non-celiac individuals. Undoubtedly, more research needs to be done to determine what, exactly these findings mean for the study of celiac disease. 

    Source:


    User Feedback

    Recommended Comments

    Only celiacs with a doctorate in chemistry would understand everything this article reveals. Couldn't you have it translated into layman's language, so the average celiac would gain insight from it!

    Share this comment


    Link to comment
    Share on other sites
    Only celiacs with a doctorate in chemistry would understand everything this article reveals. Couldn't you have it translated into layman's language, so the average celiac would gain insight from it!

    We do include a glossary of terms so that you can click on items that are triple underlined to see the definition. Keep reading the articles, and eventually the lingo will won't seem so difficult to understand. There is no easy way to summarize scientific research.

    Share this comment


    Link to comment
    Share on other sites


    Join the conversation

    You are posting as a guest. If you have an account, sign in now to post with your account.
    Note: Your post will require moderator approval before it will be visible.

    Guest
    Add a comment...

    ×   Pasted as rich text.   Paste as plain text instead

      Only 75 emoji are allowed.

    ×   Your link has been automatically embedded.   Display as a link instead

    ×   Your previous content has been restored.   Clear editor

    ×   You cannot paste images directly. Upload or insert images from URL.


  • About Me

    Jefferson Adams is Celiac.com's senior staff writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University, and has authored more than 2,000 articles on celiac disease. His coursework includes studies in biology, anatomy, medicine, science, and advanced research, and scientific methods. He previously served as SF Health News Examiner for Examiner.com, and devised health and medical content for Sharecare.com. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of the book "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.

×
×
  • Create New...