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  • Scott Adams
    Scott Adams

    Helicobacter Pylori Infection in Celiac Disease Patients

    Reviewed and edited by a celiac disease expert.

    Celiac.com 03/26/2007 - In is known that increased duodenal intraepithelial lymphocytes (IEL) are more common in celiac patients with Helicobacter pylori gastritis (H. pylori) than in those celiacs without Helicobacter pylori. It is also known that the elimination of Helicobacter pylori can reverse this problem.

    The study was motivated by the following two hypotheses:

    • Celiac patients with Helicobacter pylori might present different clinicopathological profiles from those celiacs without H.pylori.
    • Celiac patients with Helicobacter pylori might show different histopathological responses to a gluten-free diet than those celiacs without H.pylori.

    The research team compared the duodenal and gastric biopsies of 80 adults who had histologically and serologically confirmed celiac disease. The biopsies were taken both before and after patients had adhered to a gluten-free diet for 12 to 18 months.

    The team classified and scored gastritis using the Updated Sydney System. They classified duodenal biopsies using both the Marsh-Oberhuber and a simplified classification developed by the team.

    Three test subjects who were positive for Helicobacter pylori, and 12 who were negative (a total of 15 test subjects), presented with lymphocytic gastritis.

    Overall, a greater proportion of Helicobacter pylori-negative patients had severe villous atrophy (p

    Regardless of their initial Helicobacter pylori status, all subjects showed marked improvement of duodenal aspects following a gluten-free diet (p

    With the exception of the intraepithelial lymphocytes (IEL), which returned to normal in two Helicobacter pylori-positive patients, and in ten Helicobacter pylori-positive patients, gastric variables remained unchanged.

    The study concludes that Helicobacter pylori gastritis is not related to the clinical features of celiac disease, and that a gluten-free diet is equally effective for both groups.

    The study also notes that the inflammatory and structural changes to the mucosal architecture that are associated with celiac disease might eclipse some of the signs of lymphocytosis induced by Helicobacter pylori gastric infection.

    The study also further documents the pathogenic connections between celiac disease and lymphocytic gastritis.

    Am J Gastroenterol. 2006;101(8):1880-1885.


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    I'm 41 years old and was diagnosed about 8 years ago. Neither my parents have had symptoms but have both been tested (blood only). They both came back with negative results. So how did I developed this? Is spontaneous gene mutation a possibility?? And if so, how does this happen? In layman terms please.

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    One or both of your parents have a celiac gene, but that doesn't mean that they will go on to develop the disease. Only one out of five people who have a one or more celiac genes goes on to develop celiac disease. 

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  • About Me

    Celiac.com's Founder and CEO, Scott was diagnosed with celiac disease  in 1994, and, due to the nearly total lack of information available at that time, was forced to become an expert on the disease in order to recover. Scott launched the site that later became Celiac.com in 1995 "To help as many people as possible with celiac disease get diagnosed so they can begin to live happy, healthy gluten-free lives."  In 1998 he founded The Gluten-Free Mall which he sold in 2014. He is co-author of the book Cereal Killers, and founder and publisher of Journal of Gluten Sensitivity.

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