Celiac.com Sponsor (A1):


Join eNewsletter


Celiac.com Sponsor (A1-m):



Join eNewsletter
  • Join Our Community!

    Ask us a question in our celiac / gluten-free forum.

  • Scott Adams

    Highly Fluorinated Chemicals Can Raise Celiac Disease and Diabetes Risk in Children

    Scott Adams
    1 1
    Reviewed and edited by a celiac disease expert.

      Highly fluorinated chemicals can increase risk for diabetes and celiac disease in children.


    Fast food packaging can be a source of PFAS's. Image: CC BY 2.0--Calgary Reviews
    Caption: Fast food packaging can be a source of PFAS's. Image: CC BY 2.0--Calgary Reviews

    Celiac.com 09/28/2020 - Biomedical researchers Tuulia Hyötyläinen and Matej Orešič, at Örebro University, have published two studies connecting highly fluorinated chemicals to autoimmune diseases in children. In the studies, Hyötyläinen and Orešič, link per- and polyfluoroalkyl substances (PFAS's) – with type 1 diabetes and celiac disease, or gluten intolerance in children. 

    PFAS are man-made chemicals. There are about 5,000 PFAS, and they are used in numerous consumer products, such as furniture, adhesives, food packaging, coatings in clothing, and even fire-fighting foam.



    Celiac.com Sponsor (A12):






    Celiac.com Sponsor (A12-m):




    In the celiac disease study, Hyötyläinen and Orešič show a connection between PFAS and celiac disease, by demonstrating that "high exposure to PFAS in the womb and in first years of life can accelerate the development of celiac disease in children," says Hyötyläinen. The studies appear in Environment Research. 

    Their conclusions are based on analysis of the metabolization of small molecules in the body, and analysis of PFAS, coupled with a system's biology approach to integration of complex study data, gathered from expectant mothers and children.

    "Exposure to harmful chemicals in early life, including prenatally, may offer an explanation for the changing incidence of these autoimmune diseases in developed countries and can be connected to other health risks," says Matej Orešič.

    In Sweden and other Nordic countries, as in many other modern countries, type 1 diabetes is one of the most common chronic diseases among children, with cases rising sharply in the last few decades. Interestingly, the incidence curve has flattened in the last several years, which may result from stricter PFAS regulation in recent years.

    Researchers know that some children have genes that increase their likelihood of developing type 1 diabetes, but only about one in ten of them actually go on to develop diabetes. This strongly indicates an environmental factor as a potential trigger for autoimmune disease development. Both viral infections and diet have been singled out as potential triggers.

    In their recent work, Hyötyläinen and Orešič describe how PFAS impacts lipid metabolism and risk of type 1 diabetes in new-born children. Their study data shows that these chemicals are easily passed from exposed expectant mothers to the fetus. Moreover, it is known that "children exposed to the high levels of PFAS during the prenatal stage have a certain lipid profile...associated with an increased risk for type 1 diabetes and the development of the disease in children," explains Orešič.

    The team's findings are confirmed by another clinical study on children at-risk for type1 diabetes, along with two studies on experimental models of type 1 diabetes in mice.

    This is not the first study to show links between exposure to chemicals and the development of celiac disease, and other certain auto-immune conditions.

    The implications of the research for the understanding of type 1 diabetes and celiac disease in children remains unclear, as does information on safe or unsafe levels of PFAS exposure in humans. Certainly further study and consideration of the issue by researchers and clinicians is welcome. 

    Stay tuned for more on the role of pesticide and chemical exposure in the development of celiac disease and other auto-immune conditions, including type 1 diabetes.

    Read more at Medicalxpress.com

    Edited by Scott Adams

    1 1

    User Feedback

    Recommended Comments

    Scott,

    Thanks that is good research thanks for sharing!

    Here is more research about how POPs can build up and affect biological organisms negatively.

    They keep changing acronyms so you can't follow the trail.

    See this research about how in Lake Trout and PBT's their acronym leads to fish kills AKA as POPs.

    https://www.researchgate.net/figure/Hypothetical-interaction-between-contaminants-and-thiamine-deficiency-a-Toxic_fig6_237150892 

    I quote it because it has a nice diagram that shows how this could be  happening in a succinct summary form. 

    Scroll left and right through the diagrams and it will offer a good overview of how POPs build up in organisms and affect their life cycle and long term health.

    Much like you reported on in POPs in Celiac's or PFAs etc....see they changed their acronym again....but basically describes the same chemicals.

    I hope this is helpful but it is not medical advise.

    Posterboy,

    Share this comment


    Link to comment
    Share on other sites


    Join the conversation

    You are posting as a guest. If you have an account, sign in now to post with your account.
    Note: Your post will require moderator approval before it will be visible.

    Guest
    Add a comment...

    ×   Pasted as rich text.   Restore formatting

      Only 75 emoji are allowed.

    ×   Your link has been automatically embedded.   Display as a link instead

    ×   Your previous content has been restored.   Clear editor

    ×   You cannot paste images directly. Upload or insert images from URL.


  • About Me

    Scott Adams was diagnosed with celiac disease in 1994, and, due to the nearly total lack of information available at that time, was forced to become an expert on the disease in order to recover. In 1995 he launched the site that later became Celiac.com to help as many people as possible with celiac disease get diagnosed so they can begin to live happy, healthy gluten-free lives.  He is co-author of the book Cereal Killers, and founder and publisher of the (formerly paper) newsletter Journal of Gluten Sensitivity. In 1998 he founded The Gluten-Free Mall which he sold in 2014. Celiac.com does not sell any products, and is 100% advertiser supported.


  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):





    Celiac.com Sponsors (A17-m):




  • Related Articles

    Jefferson Adams
    Celiac.com 03/06/2014 - Celiac disease is associated with various nutritional and reproductive issues, and increased risk of thyroid disease, kidney failure and certain cancers.
    For reasons yet unknown, over the last forty years, celiac disease, gluten intolerance and irritable bowel syndrome, have climbed to epidemic proportions.
    Is the rapid worldwide increase in celiac disease, gluten intolerance and irritable bowel syndrome a result of the rising use of Monsanto's glyphosate herbicide, sold as Roundup?
    Yes, according to a new US peer-reviewed paper from Dr. Anthony Samsel and Dr. Stephanie Seneff. Their research indicates that glyphosate ...

    Jefferson Adams
    Celiac.com 09/13/2018 - Bob’s Red Mill finds itself under fire by two women who claim the company knowingly hides the presence of an allegedly cancer-causing weed killer in its steel cut oat and rolled oat products, and falsely advertises those products as healthy. 
    Tamara Frankel and Natasha Paracha filed a federal class action in San Francisco, alleging that parent company Bob’s Red Mill Natural Foods knows that its oat products contain or likely contain glyphosate, but fails to disclose it on the label. The women cite a recent report by the Environmental Working Group, an environmental research and advocacy group, which claimed to find trace...

    Jefferson Adams
    Celiac.com 11/19/2018 - People with celiac disease cannot reliably determine whether they ate gluten or not based on symptoms, however severe those symptoms may be, according to research presented by Amanda K. Cartee, MD, of the Mayo Clinic, and her colleagues, at the American College of Gastroenterology Annual Meeting in Philadelphia.
    Because there is presently no FDA-approved test to confirm gluten exposure, celiac patients commonly rely on the presence or absence of gastrointestinal or other symptoms as an indicator of gluten exposure. But how reliable is that method? Not very reliable at all, says Dr. Cartee.
    Now, the study was small,...

    Scott Adams
    Celiac.com 05/14/2020 - We know a lot more than ever about celiac disease, but researchers still don't have very much good information about environmental risk factors in genetically susceptible populations. For example, does environmental exposure to organic pollutants increase the risk of celiac disease?
    Researchers have documented endocrine disruption caused by ongoing exposure to persistent organic pollutants. That, along with the interplay between the endocrine and immune systems, has led them to question whether POPs may be contribute to celiac disease. 
    A team of researchers recently set out to shed some light on the connection between ...