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  • Jefferson Adams

    How Close Are New Celiac Disease Treatments?

    Jefferson Adams
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    Reviewed and edited by a celiac disease expert.

    Celiac.com 04/10/2015 - Of course, a strict gluten free diet is still the only safe and effective treatment for celiac disease. However, new drugs in development, some of which are currently being tested on humans, might allow people with celiac disease to safely eat gluten again, at least in small amounts.

    Photo: CC--Andres Nieto PorrosTo be fair, even if all goes smoothly, it will be a few years at least before we see such treatments on the market. Moreover, even though many early results have been encouraging, none have yet entered safety trials, the final step before Food and Drug Administration approval and commercial availability.



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    Drugs currently under trial include an enzyme that splits the protein in wheat that triggers adverse reactions, into smaller harmless products, and another which promises to make the gut less leaky, and thus block potentially toxic substances from triggering inflammation.

    There are several other drugs in earlier stages of development aimed at suppressing the immune response to gluten and preventing intestinal inflammation:

    • ALV003, which will protect people with celiac disease against gut damage from small amounts of gluten.
    • BL-7010 is a novel co-polymer for the treatment of celiac disease, which significantly reduces the immune response triggered by gluten.
    • ImmusanT’s therapeutic vaccine Nexvax2 combines three proprietary peptides that elicit an immune response in celiac disease patients who carry the immune recognition gene HLA-DQ2.
    • Larazotide acetate (AT-1001) is Alba Therapeutics Corporation’s investigational product, a first-in-class tight junction regulator, intended for the treatment of patients with celiac disease.
    • AVX176, from Avaxia Biologics, is an investigational oral antibody drug that is the subject of U.S. composition of matter patent 8,071,101, “Antibody Therapy for Treatment of Diseases Associated with Gluten Intolerance.” The patent, which expires on May 27 2029, provides broad coverage for treating celiac disease using orally administered antibodies produced by Avaxia’s proprietary platform technology [32].
    • ActoGenX is carrying out discovery research in celiac disease with its range of ActoBiotics™, which use Lactococcus lactis as an expression system to locally secrete bio-therapeutics such as cytokines, antibodies, hormones, etc.
    • Chemocentryx’s CCR9, is also known as Traficet-EN, or CCX282B), and was originally intended for patients with moderate-to-severe Crohn’s disease. It has completed one Phase 2 trial in 67 patients with celiac disease.

    Meanwhile, in Europe, Dr. Falk Pharma and Zedira recently announced the start of phase I clinical trials for the drug candidate ZED1227, a direct acting inhibitor of tissue transglutaminase. The small molecule targets the dysregulated transglutaminase within the small intestine in order to dampen the immune response to gluten which drives the disease process.

    Some of these drugs may be taken right before eating gluten, while others might be more effective when taken on a regular schedule. If approved for use as intended, these drugs will likely allow people with celiac disease to eat gluten in small amounts. To my knowledge, there is no drug in current trial phases that is designed to permit unrestricted gluten consumption.

    So, the good news is that the next few years may see commercially available treatments that might actual help people manage celiac disease. The downside for people with celiac disease, at least for now, is that there is no treatment on the horizon that will allow safe, unlimited gluten-consumption. Moreover, there is no hint that a cure is coming anytime soon.

    Still, it’s good to know that researchers are working on providing helpful tools for treating celiac disease.

    Are you looking forward to seeing new treatment options for celiac disease? What kind of benefits should such treatments offer?

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    "The downside for people with celiac disease, at least for now, is that there is no treatment on the horizon that will allow safe, unlimited gluten-consumption. Moreover, there is no hint that a cure is coming anytime soon."

     

    I would argue that Nexvax2 is exactly that.

     

    Also it's worth noting that today we have Bifidobacterium lactis.

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    Do you have any info where I can sign up to be in studies for celiac DX in the OKC OK area? I have biopsy proven Celiac and greatly dislike the restrictions on my lifestyle due to it. I would be interested in participating in some studies.

    I would like to sign up as well. It is a great idea. Thanks.

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    Why on Earth would I want to go back to eating gluten, I feel so much better since giving it up I have also given up most other cereals, and I certainly don't want to be dosing myself up on drugs to be able to eat bagels and cakes again.

    You are so correct. Who would want to take any medicine considering the dangerous side effects that go with anything the FDA approves. If it takes a total gluten free diet to be healthy, enjoy it. Let someone else support the Pharma world and suffer the consequences of taking dangerous drugs.

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    Guest sheila boyle rovner

    Posted

    I'm happy enough to give up bread, pasta, cake etc. entirely. (I'm middle-aged, so can't really eat starches anyway.) Just to be able to eat out with friends without having to go into long explanations and negotiations with servers about the history and provenance of every 20 parts per million would be great!

    Celiac has buried my social life. If I could go out to eat without the fear of ending up in the ER (a very sensitive celiac) or go to a party and not have to explain to the host and everyone else why I am not eating. If I could come home from a party happy because I got to taste that yummy thing that everyone was raving about. If I didn't have to spend so much time and money trying to eat gluten free. I would kiss and hug the person who developed the drug to help with this disease. Living with it is a nightmare to me. A nurse during one ER visit looked and me and said "You have to live with this? I am so sorry!" When I eat even a little bit of gluten I am in the most awful pain. OK, this is the end. Who's complaining about the expense of drug treatment? Eating gluten free is so.....expensive!

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    I applaud all the doctors, and researchers trying to find treatments, and possibly even a cure. To all those who have celiac disease, never give up hope!! I have had celiac disease for 5 years, and doing reasonably well! I would greatly welcome a treatment, being that I am a professional chef, and have to be very disciplined at home , and at work. Gluten is everywhere I go. Looking forward to more good news ahead. God Bless!!!

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    Why on Earth would I want to go back to eating gluten, I feel so much better since giving it up I have also given up most other cereals, and I certainly don't want to be dosing myself up on drugs to be able to eat bagels and cakes again.

    A vaccine is not a drug.

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  • About Me

    Jefferson Adams is Celiac.com's senior writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University, and has authored more than 2,500 articles on celiac disease. His coursework includes studies in science, scientific methodology, biology, anatomy, medicine, logic, and advanced research. He previously served as SF Health News Examiner for Examiner.com, and devised health and medical content for Sharecare.com. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of the book "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.


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