Celiac.com Sponsor (A1):

Celiac.com Sponsor (A1):

  • Join Our Community!

    Ask us a question in our celiac / gluten-free forum.

  • Scott Adams

    Is Small-Bowel Capsule Endoscopy Useful in Cases of Equivocal Celiac Disease?

    Scott Adams
    1 1
    Reviewed and edited by a celiac disease expert.

      What's the relationship between positive SBCE and celiac disease?

    A patient is prepared for an endoscopy. Image: CC BY-SA 4.0--Peggy.poon
    Caption: A patient is prepared for an endoscopy. Image: CC BY-SA 4.0--Peggy.poon

    Celiac.com 05/07/2020 - Seronegative villous atrophy (SNVA), raised intraepithelial lymphocytes (IELs) and crypt hyperplasia on duodenal histology can be caused by celiac disease or by drugs or infections.

    A team of researchers recently set out to assess the role of small-bowel capsule endoscopy (SBCE) in these patients and to determine SBCE findings at diagnosis can predict disease outcome.

    Celiac.com Sponsor (A12):

    The research team included Stefania Chetcuti Zammit, Annalisa Schiepatti, Imran Aziz, Matthew Kurien, David S. Sanders, and Reena Sidhu. They are variously affiliated with the Academic Unit of Gastroenterology, Royal Hallamshire Hospital, Sheffield, UK, and the Academic Unit of Gastroenterology, Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield Medical School, Sheffield.

    The team assessed 177 patients with SNVA, IELs +/-crypt hyperplasia on duodenal histology. These patients all had an equivocal diagnosis of celiac disease.

    About one in three patients had a positive SBCE. Most patients had disease affecting the proximal third of the small bowel. All patients in the SNVA-celiac disease group who later developed poor outcomes had a positive SBCE. 

    These patients also showed much more widespread small bowel disease than those with no adverse incidents. More-extensive small bowel disease on SBCE was associated with a higher SNVA-related deaths in patients with SNVA-UO and SNVA-celiac disease. 

    Interestingly, severity of gut damage did not correlate with mortality, meaning that it's possible to recover and become healthy.

    Overall, the team found that positive SBCE at diagnosis corresponds to a worse celiac disease outcome. Crucially, widespread disease in these patients is associated with poor survival rates. Spotting and aggressively treating patients with extensive disease at diagnosis can improve outcomes for many of these patients.

    Read more at: Gastrointestinal Endoscopy

    Edited by Scott Adams

    1 1

    User Feedback

    Recommended Comments

    There are no comments to display.

    Join the conversation

    You are posting as a guest. If you have an account, sign in now to post with your account.
    Note: Your post will require moderator approval before it will be visible.

    Add a comment...

    ×   Pasted as rich text.   Paste as plain text instead

      Only 75 emoji are allowed.

    ×   Your link has been automatically embedded.   Display as a link instead

    ×   Your previous content has been restored.   Clear editor

    ×   You cannot paste images directly. Upload or insert images from URL.

  • About Me

    Scott Adams was diagnosed with celiac disease in 1994, and, due to the nearly total lack of information available at that time, was forced to become an expert on the disease in order to recover. In 1995 he launched the site that later became Celiac.com to help as many people as possible with celiac disease get diagnosed so they can begin to live happy, healthy gluten-free lives.  He is co-author of the book Cereal Killers, and founder and publisher of the (formerly paper) newsletter Journal of Gluten Sensitivity. In 1998 he founded The Gluten-Free Mall which he sold in 2014. Celiac.com does not sell any products, and is 100% advertiser supported.

  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):

    Celiac.com Sponsors (A17):

  • Related Articles

    Jefferson Adams
    Celiac.com 01/02/2012 - To properly diagnose celiac disease doctors must observe classic histological changes to small bowel mucosa. Success rates can vary among clinics and practitioners. A clinical team recently compared biopsy interpretation between different pathology practice types.
    A research team recently assessed variability in small bowel histopathology reporting between different pathology practice settings, and its impact celiac disease diagnosis.
    The researchers included Carolina Arguelles-Grande, Christina A. Tennyson, Suzanne K. Lewis, Peter H. R. Green, and Govind Bhagat.
    The team used a pathologist to blindly assessed biopsies...

    Jefferson Adams
    Celiac.com 02/26/2020 - Patients with established celiac disease can present with signs and symptoms requiring small bowel capsule endoscopy (SBCE) to assess for persistent disease beyond the duodenum and to rule out complications. 
    There is limited data celiac disease and histology, clinical and serological parameters as they reflect the extent of celiac disease on small bowel capsule endoscopy.
    A team of researchers recently set out to assess the role of small bowel capsule endoscopy in established celiac disease, by looking at the relationship between symptoms, celiac disease serology and Marsh classification of disease and extent of d...

    Jefferson Adams
    Celiac.com 02/10/2020 - There are no articles in the medical literature about the role of repeat small bowel capsule endoscopy (SBCE) in patients with refractory celiac disease (RCD) following treatment with steroids and/or immunosuppressants.
    A team of researchers recently set out to compare the findings on SBCEs from a group of 23 patients with histologically proven RCD against the results of 48 patients with uncomplicated celiac disease. All patients had concurrent duodenal histology and serology taken at the time of SBCE.
    The team included Stefania Chetcuti Zammit, David S. Sanders, Simon S. Cross, and Reena Sidhu. They are variously...

    Jefferson Adams
    Celiac.com 03/11/2020 - Researchers don't have a very good understanding about the connection between symptoms, blood tests, and the results of small bowel capsule endoscopy (SBCE) in celiac patients. 
    Better understanding such connections will help to figure out whether symptoms and blood tests can determine the severity and extent of disease using SBCE. 
    A team of researchers recently set out determine if symptoms and blood tests can determine the severity and extent of disease using SBCE. The team included Stefania Chetcuti Zammit, David S. Sanders and Reena Sidhu, of the Academic Unit of Gastroenterology, Royal Hallamshire Hospital, S...