Jump to content
  • Sign Up
Celiac.com Sponsor:


Celiac.com Sponsor:


  • Join Our Community!

    Get help in our celiac / gluten-free forum.

  • Jefferson Adams

    Leaky Gut Could Be a Real Problem for Space Travelers

    Jefferson Adams


    Reviewed and edited by a celiac disease expert.

      A research team studying the effects of microgravity on intestinal epithelial cells has found that simulated microgravity, such as that encountered in spaceflight, disrupts the functioning of the epithelial barrier after a return to regular gravity.


    Caption: Astronaut John M. Grunsfeld EVA. Image: CC BY 2.0--NASA Hubble

    Celiac.com 12/09/2019 - When humans eat food, we also introduce bacteria, fungi, and viruses into our gut. Here on Earth, the epithelial cells that line the gut usually work to prevent these microorganisms from crossing into our blood stream. However, little is known about how microgravity effects epithelial barrier function.

    Some previous studies have shown that microgravity weakens the human immune system and increases entero-pathogen virulence. To get a better understanding of the problem, a team of researchers set out to see if microgravity changes intestinal epithelial permeability, and susceptibility, to barrier-disrupting agents.



    Celiac.com Sponsor:




    A research team led by a biomedical scientist at the University of California, Riverside, has found that simulated microgravity, such as that encountered in spaceflight, disrupts the functioning of the epithelial barrier, even after the person returns to a regular gravity environment.

    The research team included Rocio Alvarez, Cheryl A. Stork, Anica Sayoc-Becerra, Ronald R. Marchelletta, G. Kim Prisk and Declan F. McCole. They are variously associated with the Division of Biomedical Sciences at the University of California, Riverside in Riverside, CA; the Cedars-Sinai Medical Center in Los Angeles, CA; the Department of Medicine, University of California, San Diego in La Jolla, CA; the Department of Radiology at the University of California, San Diego in La Jolla, CA; and the Johnson & Johnson Research Laboratories, Janssen Pharmaceuticals Inc. in La Jolla, CA.

    For their study, the team cultured intestinal epithelial cells (HT-29.cl19a) on microcarrier beads in simulated microgravity using a rotating wall vessel (RWV) for 18 days. They then seeded the iECs on semipermeable supports to measure ion flux (transepithelial electrical resistance (TER)) and FITC-dextran (FD4) permeability over 14 days.

    RWV cells showed delayed apical junction localization of the tight junction proteins, occludin and ZO-1. Compared with static, motion and flask control cells, RWV cells treated with alcohol metabolite, acetaldehyde, showed sharp decrease in TER, along with reduced junctional ZO-1 localization, and increased FD4 permeability.

    Based on these data, the team concludes that simulated microgravity makes the gut susceptible to epithelial barrier permeability upon removal from the microgravity environment, which means that space travelers are more likely to develop gastrointestinal issues, such as leaky gut, once they return to earth.

    Studies like this help to shed a light on how the body's gastrointestinal system functions in space travelers, especially in astronauts, and to help us better the factors that can compromise intestinal epithelial barrier function following return to Earth.

    Read more in Scientific Reports volume 9, Article number: 17531 (2019)


    User Feedback

    Recommended Comments

    There are no comments to display.



    Join the conversation

    You are posting as a guest. If you have an account, sign in now to post with your account.
    Note: Your post will require moderator approval before it will be visible.

    Guest
    Add a comment...

    ×   Pasted as rich text.   Paste as plain text instead

      Only 75 emoji are allowed.

    ×   Your link has been automatically embedded.   Display as a link instead

    ×   Your previous content has been restored.   Clear editor

    ×   You cannot paste images directly. Upload or insert images from URL.


  • About Me

    Jefferson Adams is Celiac.com's senior writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University, and has authored more than 2,500 articles on celiac disease. His coursework includes studies in science, scientific methodology, biology, anatomy, medicine, logic, and advanced research. He previously served as SF Health News Examiner for Examiner.com, and devised health and medical content for Sharecare.com. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of the book "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.

  • Related Articles

    Jefferson Adams
    Celiac.com 11/20/2015 - A Canadian researcher has discovered what might be a big step toward preventing celiac disease. Dr. Elena Verdú, an associate professor at the Farncombe Family Digestive Health Research Institute at McMaster University, has found that bacteria in the gut may contribute to the body's response to gluten. 
    If her discovery pans out, it may be possible t...

    Jefferson Adams
    Celiac.com 04/25/2018 - A team of Yale University researchers discovered that bacteria in the small intestine can travel to other organs and trigger an autoimmune response. In this case, they looked at Enterococcus gallinarum, which can travel beyond the gut to the spleen, lymph nodes, and liver. The research could be helpful for treating type 1 diabetes, lupus, and celiac disease...

    Jefferson Adams
    Celiac.com 12/20/2018 - Intestinal permeability is thought to play a key role in the translocation of bacteria that lead to nonalcoholic fatty liver disease (NAFLD), a disorder in which fat accumulates in the liver. Intestinal permeability is also thought to play a significant role in the development of Nonalcoholic steatohepatitis (NASH).
    In a new preclinical study, a team...

    Jefferson Adams
    Celiac.com 09/04/2019 - Class II human leukocyte antigen (HLA) allele combinations exert strong genetic control over susceptibility to numerous autoimmune diseases. Researchers know that these genes are the most significant risk factors for Type 1 diabetes and celiac disease, but they still know very little about how HLA influences the makeup of the human gut microbiome, which ...

  • Celiac.com Sponsor:

  • Forum Discussions

    For the OP, Yes, if you're gluten sensitive or a celiac, you tend to react stronger to gluten than before you went gluten-free.  I get even a the slightest bit of cross contamination I get headaches for a few days and terrible reflux ...
    It's supposed to be specified as corn/wheat here but I do see items pretty often labelled just "modified food starch".  Unless it states specifically corn, I stay away from it. 
    It's possible that being gluten free for two weeks could cause a false negative. Add to that over the last couple years you've eaten "lower" gluten diet.  Definitely possible. Unfortunately, you'd have to eat gluten for a couple of weeks ...
×
×
  • Create New...