Jump to content
This site uses cookies. Continued use is acceptance of our Terms of Use and Privacy Policy. More Info... ×
  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.




  • Celiac.com Sponsor (A1):



    Celiac.com Sponsor (A1-M):


  • Get Celiac.com Updates:
    Help Celiac.com:
    eNewsletter
    Donate
  • Record is Archived

    This article is now archived and is closed to further replies.

    Roy Jamron
    Roy Jamron

    Liver Damage, Celiac Disease and the Intestinal Mucosa by Roy Jamron

    Reviewed and edited by a celiac disease expert.

    Celiac.com 04/27/2006 - Liver abnormalities have been found in a high percentage of celiacs when first diagnosed, around 42% according to some studies. Gluten toxicity and increased intestinal permeability have both been suspected as a cause of liver abnormalities. Serious liver disorders, including cirrhosis, have been found in association with a number of celiac disease cases which appear to resolve upon treatment and maintaining a gluten-free diet. It is not clear whether some damage to the liver may remain long term even after maintaining a gluten-free diet. Below is an interesting study (Hepatology. 2006 Mar 23;43(4):837-846) of the effects of induced liver cirrhosis on the intestinal mucosa which results in oxidative stress and an alteration of intestinal permeability, intestinal bacteria makeup, and bacterial overgrowth. Hence not only does damage to the intestine in response to gluten often result in bacterial overgrowth, but damage to the liver by gluten may also contribute to bacterial overgrowth and mucosal alterations.

    Damage to the liver caused by celiac disease may also have other consequences, as the liver plays many important roles including storage and production of important compounds and proteins and the removal of fat soluble toxic substances. As we are increasingly exposed to endocrine disrupting xenobiotic environmental chemicals and toxic substances, a dysfunctional livers inability to remove fat soluble toxic substances may leave celiacs more susceptible to adverse effects from these chemicals which can accumulate in adipose (fatty) tissue. In the Winter 2006 issue of Open Original Shared Link, I discuss in detail, in Unraveling Fibromyalgia, how a dysfunctional liver and fat soluble toxic substances accumulating in innervated and vascularlized adipose tissue in the vicinity of joints may be the cause of fibromyalgia. Bacterial overgrowth has also been found in association with fibromyalgia. But clearly, lesser degrees of fatigue, muscle and joint pain, thyroid disorders, and other symptoms could also result from liver dysfunction caused by celiac disease. The inability of the liver to remove xenobiotic chemicals may also increase the risk of breast and other cancers.

    Celiac.com Sponsor (A12):
    Recently a new review on liver disorders and celiac disease has appeared (See below - World J Gastroenterol 2006 March 14;12(10): 1493-1502 and 1503-1508): Liver Damage and the Intestinal Mucosa. One cannot ignore the secondary effects and symptoms that liver damage may add to those symptoms caused by glutens effect on the intestinal mucosa. Those unexplained aches and pains and other symptoms and disorders which have frequently been reported by some celiacs may be a result of liver dysfunction.

    Some notes: Elevated liver enzymes are the result of liver enzymes released by damaged liver cells. The article cites one study stating A gluten-free diet for 1 to 10 years resulted in complete normalization of liver chemistry tests in 95% patients. Normal liver chemistry tests DO NOT necessarily mean that the liver is functioning normally and that no damage remains. See: Special Considerations in Interpreting Liver
    Function Tests - Open Original Shared Link

    Referenced Abstracts:

    Hepatology. 2006 Mar 23;43(4):837-846

    Intestinal mucosal alterations in rats with carbon tetrachloride-induced cirrhosis: Changes in glycosylation and luminal bacteria.

    Natarajan SK, Ramamoorthy P, Thomas S, Basivireddy J, Kang G, Ramachandran A, Pulimood AB, Balasubramanian KA.

    The Wellcome Trust Research Laboratory, Department of Gastrointestinal Sciences, Christian Medical College, Vellore, India.

    Spontaneous bacterial peritonitis is a major cause of mortality after liver cirrhosis. Altered permeability of the mucosa and deficiencies in host immune defenses through bacterial translocation from the intestine due to intestinal bacterial overgrowth have been implicated in the development of this complication. Molecular mechanisms underlying the process are not well known. In order to understand mechanisms involved in translocation of bacteria, this study explored the role of oxidative stress in mediating changes in intestinal mucosal glycosylation and luminal bacterial content during cirrhosis. CCl(4)-induced cirrhosis in rats led to prolonged oxidative stress in the intestine, accompanied by increased sugar content of both intestinal brush border and surfactant layers. This was accompanied by changes in bacterial flora in the gut, which showed increased hydrophobicity and adherence to the mucosa. Inhibition of xanthine oxidase using sodium tungstate or antioxidant supplementation using vitamin E reversed the oxidative stress, changes in brush border membrane sugar content, and bacterial adherence. In conclusion, oxidative stress in the intestine during cirrhosis alters mucosal glycosylation, accompanied by an increased hydrophobicity of luminal bacteria, enabling increased bacterial adherence onto epithelial cells. This might facilitate translocation across the mucosa, resulting in complications such as spontaneous bacterial peritonitis.

    World J Gastroenterol 2006 March 14;12(10):1503-1508

    Hepatobiliary and pancreatic disorders in celiac disease

    Hugh James Freeman

    Free full text:

    Open Original Shared Link
    Open Original Shared Link
    Open Original Shared Link

    Increasing evidence suggests that derangement of gut flora is of substantial clinical relevance to patients with cirrhosis. Intestinal bacterial overgrowth and increased bacterial translocation of gut flora from the intestinal lumen, in particular, predispose to an increased potential for bacterial infection in this group. Recent studies suggest that, in addition to their role in the pathogenesis of overt infective episodes and the clinical consequences of sepsis, gut flora contributes to the pro-inflammatory state of cirrhosis even in the absence of overt infection. Furthermore, manipulation of gut flora to augment the intestinal content of lactic acid-type bacteria at the expense of other gut flora species with more pathogenic potential may favorably influence liver function in cirrhotic patients. Here we review current concepts of the various inter-relationships between gut flora, bacterial translocation, bacterial infection, pro-inflammatory cytokine production and liver function in this group.



User Feedback

Recommended Comments

Guest Rhonda Jared

Posted

Well written, technical, but understandable. Doctors should be made aware of the celiac disease-liver relationship. I'm making a copy for my own doc.

Link to comment
Share on other sites
Guest Christine

Posted

Well written, technical, but understandable. Doctors should be made aware of the celiac disease-liver relationship. I'm making a copy for my own doc.

I was an undiagnosed celiac for 20 years. The results are 2 premature babies, the bone density of an 80 year old woman, migraines, and this article has made it clear where my fatty liver disease has come from. I've read extensively on celiac research but want to know can it be reversed and what other lifestyle changes do I need to make to recover from this. So much excellent research now on the 'why' but what we need is the 'how'.

Link to comment
Share on other sites
Guest Sandy

Posted

I was diagnosed at 46 with celiac disease, found because of elevated liver enzymes by myself. When I went off gluten, my enzymes returned to normal for a while and now are creeping back up to a high normal number. I also had my gallbladder removed and had what they called gallbladder disease without the gallbladder. This article has helped me a lot in understanding my problem now and I wish the doctor would read this article as well. Thank you

Link to comment
Share on other sites


Guest
This is now closed for further comments

  • Get Celiac.com Updates:
    Help Celiac.com:
    Donate
  • About Me

    Roy Jamron

    Roy S. Jamron holds a B.S. in Physics from the University of Michigan and an M.S. in Engineering Applied Science from the University of California at Davis, and independently investigates the latest research on celiac disease and related disorders.


  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):





    Celiac.com Sponsors (A17-M):




  • Related Articles

    Roy Jamron
    Celiac.com 05/31/2006 - I Open Original Shared Link how liver abnormalities are highly prevalent in celiac disease. Why damage to the liver occurs is unknown, and gluten toxicity and increased intestinal permeability have been proposed as factors. The following free full text article appearing in the current issue of Gastroenterology may shed light on why liver damage occurs in celiacs.
    Toll-like receptors (TLRs) reside on the surface of many cells which participate in the immune system. TLRs sense molecules present in pathogens but not the host, and when the immune system senses these molecules, chemicals are released which set off inflammatory and anti-pathogen responses. One class of molecules recognized by TLRs and common to most pathogenic bacteria is lipopolysaccharides...


  • Recent Activity

    1. - cristiana replied to djmu's topic in Related Issues & Disorders
      5

      Peripheral Neuropathy

    2. - Tlbaked13 replied to djmu's topic in Related Issues & Disorders
      5

      Peripheral Neuropathy

    3. - trents replied to djmu's topic in Related Issues & Disorders
      5

      Peripheral Neuropathy

    4. - shadycharacter replied to Linedancegal's topic in Introduce Yourself / Share Stuff
      5

      25 year biopsy confirmed/ate pizza with no ill effects?

    5. - Tlbaked13 replied to djmu's topic in Related Issues & Disorders
      5

      Peripheral Neuropathy


    • Celiac.com Sponsor (A19):



    • Member Statistics

      • Total Members
        120,467
      • Most Online (within 30 mins)
        7,748

      MorticiaCat
      Newest Member
      MorticiaCat
      Joined

    • Celiac.com Sponsor (A20):


    • Forum Statistics

      • Total Topics
        120.2k
      • Total Posts
        1m

    • Celiac.com Sponsor (A22):





    • Celiac.com Sponsor (A21):



    • Popular Now

      • Linedancegal
      • Hannah24
        7
      • jessiemariecar
      • Rhonda H
      • HayleyC123
    • Popular Articles

      • Scott Adams
      • Scott Adams
      • Scott Adams
      • Scott Adams
      • Scott Adams
    • Upcoming Events

    ×
    ×
    • Create New...