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  • Scott Adams
    Scott Adams

    Malignancy and Mortality in People with Celiac Disease: Population Based Cohort Study

    Reviewed and edited by a celiac disease expert.

    BMJ. 2004 Jul 21

    Celiac.com 08/09/2004 – In a study designed to quantify the malignancy and mortality risks associated with celiac disease, British researchers examined 4,732 celiac disease patients and compared them to 23,620 matched controls. The researchers found that 134 (2.8%) of those with celiac disease had at least one malignancy, and 237 (5.0%) had died. In the general population, the overall hazard ratios were as follows: for any malignancy 1.29 (95% confidence interval 1.06 to 1.55), for mortality 1.31 (1.13 to 1.51), for gastrointestinal cancer 1.85 (1.22 to 2.81), for breast cancer 0.35 (0.17 to 0.72), for lung cancer 0.34 (0.13 to 0.95), and for lymphoproliferative disease 4.80 (2.71 to 8.50).

    The researchers conclude that there is a modest increase in the rates of malignancy and mortality during the first year following a diagnosis of celiac disease. After one year, however, most of that increase quickly diminishes to a level that is only slightly higher than that of the normal population, presumably due to the effects of a gluten-free diet. In an unexpected finding the researchers also found a significant reduction in incidence of breast cancer in those with celiac disease, which warrants further study, as it could provide insight into the cause of the disease.


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  • About Me

    Celiac.com's Founder and CEO, Scott was diagnosed with celiac disease  in 1994, and, due to the nearly total lack of information available at that time, was forced to become an expert on the disease in order to recover. Scott launched the site that later became Celiac.com in 1995 "To help as many people as possible with celiac disease get diagnosed so they can begin to live happy, healthy gluten-free lives."  In 1998 he founded The Gluten-Free Mall which he sold in 2014. He is co-author of the book Cereal Killers, and founder and publisher of Journal of Gluten Sensitivity.

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