Jump to content
  • Sign Up
  • Join Our Community!

    Get help in our celiac / gluten-free forum.

  • Jefferson Adams
    Jefferson Adams

    Micronutrient Deficiencies are Common in Adults with Celiac Disease

    Reviewed and edited by a celiac disease expert.

      How common are micronutrient deficiency in adults with celiac disease? 

    Caption: Image: CC BY 2.0--WebNutrients

    Celiac.com 07/10/2019 - Fewer new celiac patients are being diagnosed with classical malabsorption problems. Has this fact had any impact on nutrient deficiency? A team of researchers recently set out to evaluate micronutrient deficiencies in a contemporary group of adult patients with newly diagnosed celiac disease.

    The research team included Adam C. Bledsoe MD; Katherine S. King MS; Joseph J. Larson BS; Melissa Snyder PhD; Imad Absah MD; Rok Seon Choung MD, PhD; and Joseph A.Murray MD. They are variously affiliated with the Division of Gastroenterology and Hepatology, the Division of Biomedical Statistics and Informatics, the Division of Clinical Biochemistry, and the Division of Pediatric Gastroenterology at the Mayo Clinic in Rochester, MN; and the Department of Pediatrics at the University of Southern Denmark, Odense.

    The team conducted a retrospective study of prospective adults newly diagnosed with celiac disease from January 1, 2000, through October 31, 2014, at Mayo Clinic. They collected micronutrient data levels of tissue transglutaminase IgA, 25-hydroxy vitamin D, albumin, copper, ferritin, serum folate vitamin B12, and zinc.

    The researchers used logistic regression to assess absolute number of deficiencies, and their connections with age, sex, body mass index, presenting symptoms, and tissue transglutaminase IgA. They then compared deficiencies with age- and sex-matched controls from the National Health and Nutrition Examination Survey.

    The team looked at a total of 196 women and 113 men with celiac disease. The team showed that about 25 percent of those patients showed weight loss, while nearly 60 percent showed zinc was deficient, compared with just with 33.2 percent of controls. Nearly 20 percent of patients showed low albumin compared with just 1.1 percent of controls. 

    More than 6 percent of celiac patients showed low copper levels compared with 2.1 percent of control subjects. More than 5 percent of celiac patients showed low vitamin B12 levels, compared with 1.8 percent of control subjects. 

    Low folate levels were found in nearly 4 percent of celiac patients compared with just 0.3 percent of control subjects. Meanwhile, ferritin was low in 30.8 percent of celiac patients, though no NHANES controls were available for comparison for ferritin.

    Adults with celiac disease often have micronutrient deficiencies, even though less of them show signs of classical malabsorption. This study supports testing celiac patients for micronutrient deficiencies at the time of diagnosis.

    Read more at ScienceDirect.com

    User Feedback

    Recommended Comments

    I over the years was low in Mg/calcium,and B vitamins for years, an alternative Dr suggestion I supplement helped to manage my myalgia and connective/nerve issues. In time a Dr diagnosed me vitamin D deficient that also helped. The gi issues were long present with no permanent relief.  As for zinc that one shows on my nails mostly toes, but even fingers on and off over the years.

    edit: I forgot the alternative Dr who suggest mg/ca, b vitamins, also had me on probiotics long before they became common place and were sold in stores otc. I will never know how this helped my immune system as it was 20 plus years before I got a formal diagnosis. However removing  gluten is really the gi support that helps.

    Thanks for the info Mr. Adams. I do think in time your information will help educate people.


    Share this comment

    Link to comment
    Share on other sites

    Join the conversation

    You are posting as a guest. If you have an account, sign in now to post with your account.
    Note: Your post will require moderator approval before it will be visible.

    Add a comment...

    ×   Pasted as rich text.   Paste as plain text instead

      Only 75 emoji are allowed.

    ×   Your link has been automatically embedded.   Display as a link instead

    ×   Your previous content has been restored.   Clear editor

    ×   You cannot paste images directly. Upload or insert images from URL.

  • About Me

    Jefferson Adams is Celiac.com's senior writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University, and has authored more than 2,000 articles on celiac disease. His coursework includes studies in science, scientific methodology, biology, anatomy, medicine, logic, and advanced research. He previously served as SF Health News Examiner for Examiner.com, and devised health and medical content for Sharecare.com. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of the book "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.

  • Related Articles

    Jefferson Adams
    Celiac.com 05/11/2015 - Many people with celiac disease know that gluten exposure can cause gut damage and trouble absorbing some vitamins and minerals, which can lead to serious deficiencies. However, even celiac who follow gluten-free diets may experience similar issues, including impaired vitamin and mineral absorption.
    The most common vitamin and mineral deficiencies...

    Jefferson Adams
    Celiac.com 07/17/2018 - What can fat soluble vitamin levels in newly diagnosed children tell us about celiac disease? A team of researchers recently assessed fat soluble vitamin levels in children diagnosed with newly celiac disease to determine whether vitamin levels needed to be assessed routinely in these patients during diagnosis.
    The researchers evaluated the symptoms of c...

    Jefferson Adams
    Celiac.com 08/16/2018 - What is the significance of vitamin D serum levels in adult celiac patients? A pair of researchers recently set out to assess the value and significance of 25(OH) and 1,25(OH) vitamin D serum levels in adult celiac patients through a comprehensive review of medical literature.
    Researchers included F Zingone and C Ciacci are affiliated with the Gastroenterology ...

  • Forum Discussions

    If her celiac blood test normalized and her second endoscopy and colonoscopy (with the pathologist confirming this besides the GI) revealed a healed small intestine, but found ulcers, she may be dealing with something else like Inflammatory ...
    No. I agree with what Scott said.  So much is not true in this post.  
    I’ve never heard of a pure rice, eggs, salmon or chicken that would contain gluten (no matter what is fed to the animals). Please be careful of the claims you make in a public forum like this, and provide evidence when you make such claims. It ...
  • Create New...