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  • Jefferson Adams
    Jefferson Adams

    What is Nanojuice, and How Can it Help Diagnose Celiac Disease?

    Celiac.com 08/01/2014 - I sometimes have to remind myself that it’s the 21st century, and that some amazing scientific breakthroughs that sound like something out of science fiction are, in fact, real.

    Photo: Wikimedia Commons--ARSTake for example the technology, recently developed by researchers at the University at Buffalo, that allows researchers to safely examine intestines using nanoparticles. The popular name for these orally administered nanoparticles suspended in liquid is ‘Nanojuice.’

    Human small intestines are each about 23 feet long and 1 inch thick. Located between the stomach and the large intestine, the small intestine is notoriously difficult to examine, hence procedures like biopsies, endoscopies, etc.

    The new technique, being developed by researchers at the University at Buffalo, uses nanoparticles and lasers to image the organ. Once the nanoparticles reach the intestines, doctors can strike the particles with a harmless laser. The technique provides real-time view of the intestine. This will help doctors diagnose irritable bowel syndrome, celiac disease, Crohn's disease and other gastrointestinal illnesses, according to the researchers.

    So far, the research team has only tested their technology on mice, but they plan to refine the technique for clinical trials on human subjects. Researchers say that this method can help doctors get a better picture of the nature of celiac and other diseases.

    The study is published in the journal Nature Nanotechnology.

    What do you think? Will products like nanojuice represent the future of celiac disease diagnosis? If it is shown to be safe, would you prefer it to a biopsy?

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    If only celiac disease could be diagnosed for sure or not it would be so much better knowing if you had to be on the starvation diet.

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  • About Me

    Jefferson Adams earned his B.A. and M.F.A. at Arizona State University, and has authored more than 2,000 articles on celiac disease. His coursework includes studies in biology, anatomy, medicine, science, and advanced research, and scientific methods. He previously served as Health News Examiner for Examiner.com, and devised health and medical content for Sharecare.com. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of the book "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.

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    Scott Adams
    The following was written by one of the CEDAR staff, Stephanie Tudor - TudorS@jove.uchsc.edu. Anyone with further questions should contact her directly. If you live in Denver and are biopsy-confirmed, they would love to hear from you.
    The Celiac Disease Autoimmunity Research (CEDAR) project is affiliated with the Department of Preventive Medicine and Biometrics in the School of Medicine of the University of Colorado, Health Sciences Center. It is a project supported by a grant from the National Institutes of Health (NIH), and will collect data for a total of five years. The principal investigator is Marian J. Rewers, MD, MPH, Ph.D. Other co-investigators include: Jill Norris, Ph.D.; George Eisenbarth, MD, Ph.D.; Ronald J. Sokol, MD; and Edward Hoffenberg, MD.
    The goals of this study are primarily to investigate the genetic and environmental causes of celiac disease, through the determination of the prevalence of anti-endomysial antibodies (EMA) in children considered to be at risk based on their family history (first degree relative) of either diabetes mellitus (Type I) or celiac disease or based on their HLA genotype (DR3) that is suspected to put them at an increased risk. The study is anticipating an enrollment of approximately 3,000 eligible children under the age of ten years. Most of the children reside in the Denver metro area, and a large proportion (approximately 40%) of the children involved with this research are concurrently enrolled in the Diabetes Autoimmunity Study in the Young (DAISY), which is run by the same principal investigator. The DAISY project is evaluating the presence of autoimmunity in relation to a pre-diabetic (insulin dependent diabetes mellitus) condition.
    The enrolled subjects are screened initially between the ages of two and five years of age with a serum sample tested using an IgA-based anti-endomysial antibody assay. The serum samples are also screened for IgA levels in order to rule out the potential for false negative results in IgA deficient children. For the subjects who are tested at a positive titration, follow-up includes a clinic evaluation and small bowel biopsy at the Pediatric Gastroenterology Department at the Childrens Hospital of Denver, Colorado. If a diagnosis of celiac is made, the subject is referred for nutritional counseling and follow-up serum testing is done six months after the diagnosis to confirm effective treatment. Dietary factors are also collected upon enrollment of the subjects, reflecting dietary changes that are made between the ages of one and two years of age, as the introduction of gluten into the diet usually occurs in this time frame. Information on family history of other autoimmune conditions is also collected. Subjects who test negative for the presence of anti-endomysial antibodies will be re-screened two years after their initial testing, to verify their immune status with respect to the anti-endomysial antibodies.
    By the end of the study period, we hope to have data that more accurately defines the prevalence of celiac disease in a United States population. The children recruited based on their HLA type are from a general population screening, and their data should be able to provide more accurate statistics on prevalence, and perhaps incidence, as some of these children have been followed since birth. We also hope to have identify associations with potential environmental exposures which may increase susceptibility to celiac disease.

    Scott Adams
    Celiac.com 01/31/2005 - SEOs (Search Engine Optimizers) are having a contest to see who will rank #1 in Google for the nonsense phrase "V7ndotcom elursrebmem" on May 15th, 2006 with a first prize of $7,000 and a 30 GByte iPod. With that much money at stake, SEOs world-wide are using all of their bags of tricks and strategies (including some nefarious black hat techniques) to "convince" Google that their web site should rank #1. But one underdog web site is giving these seasoned professionals one heck of a run for the money and trying to win that prize money for a good cause. www.watching-paint-dry.com will donate all contest winnings directly to charity -- specifically, the University of Maryland Center for Celiac Research (CFCR). And with a groundswell of interest, it just might win that $7,000 for Celiac Disease as countless web sites have taken notice and are already talking/linking to it a spontaneous grassroots effort to help out. In fact, this Press Release was handled by one cyberspace supporter who graciously volunteered (thank you "FrankB somewhere in the Canadian Rockies") to submit it.
    Three days into the contest, Google says (screenshot) there are 32,500 v7ndotcom elursrebmem web pages with the celiac charity site ranking #1. But can it retain that spot for 4 months to win the $7,000 -- stay tuned!
    While the person behind the V7ndotcom Elursrebmem for Charity web site wishes to remains anonymous, the web site states: "the reason Im doing this is because my two kids have Celiac Disease -- an intolerance of gluten ... and when my kids grow up, I would like to be able to go out and have a beer and pizza with them." The CFCR web site says: "we have worked with them before and are appreciative of their latest efforts to not only increase awareness about Celiac, but also raise funds for our research efforts."
    CFCR Operations Director Pam King adds: "This sounds like an interesting contest and the Center is pleased to be working again with a very committed person who cares deeply about his kids and helping us find a cure for celiac disease." CFCR Medical Director Dr. Fasano comments: "V7ndotcom elursrebmem sounds like a dreadful malady, but celiac disease is my top priority right now and every research dollar brings us one step closer to finding a cure for it."
    Web site owners can help out by linking to the V7ndotcom Elursrebmem for Charity web site by letting others know and adding a link to the V7ndotcom Elursrebmem for Charity site. You will be entered in the random drawing for that 30 GByte iPod being given away for the contest. And anyone can make a tax-deductible contribution to the CFCR now, by clicking on the donation button on the site.
    About University of Maryland Center for Celiac Research
    Is an institution engaged in clinical care, diagnostic support, education, and clinical and basic science research in Celiac Disease.
    Operations Director Pam King can be reached at (410) 706-8021 and/or pking@peds.umaryland.edu
    Resource Link: http://www.celiaccenter.org/seo_contest.asp

    Tina Turbin
    Celiac.com 10/12/2011 - According to recent estimates, three million Americans suffer from celiac disease—approximately 1% of the population, and only three percent of them have to this writing been correctly diagnosed. As startling as that sounds to us all, according to a news article on Medscape Today, the incidence of celiac disease has increased markedly over the last three decades, perhaps even as fourfold, and studies are suggesting the incidence may actually be higher than 1% of the population.
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    The Medscape article went on to report that the Mayo Clinic has confirmed increase in celiac disease incidence, reported in Discovery's Edge, the Mayo Clinic's research magazine. Dr. Joseph Murray, MD, and colleagues analyzed stored blood samples from Air Force recruits in the early 1950s for gluten antibodies. It was assumed that 1% would be positive, given today's estimates, but the number of positive results was far smaller. Dr. Murray and his colleagues compared their results with two more recently collected sets with the conclusion that celiac disease is about four times more common today than it was in the 1950s.
    Additionally, Dr. Ludviggon's research team in Sweden has found that those living with celiac disease and latent celiac disease have higher mortality than those who don't have these conditions. Latent celiac disease is also known as "gluten sensitivity," a term to describe those who have "normal small intestinal mucosa but positive celiac disease serology," estimated to affect 1 in 1000 people. According to Dr. Ludvigsson's research team, in 1 year, 10 of 1000 individuals with celiac disease will die, as compared with 7 in 1000 individuals without the disease. The mortality rate is increased among those who also have latent celiac disease as well. The increased risk, however, is quite small.
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    Jefferson Adams
    Celiac.com 06/26/2014 - Imagine being able to go to a party, or a restaurant, and test any food on your plate for gluten.
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    The portable test would work by placing a sample of food would be placed in a disposable pod and placing the pod in a sensor.
    Once activated, the device would tell you, in two minutes or less, if the food sample contained any gluten over the FDA standard of 20 ppm gluten or more.
    The sensor could also be used to detect gluten in any packaged foods.
    The sensor is designed to test a specific section of food on your plate, or a sauce, soup or liquid. It would not be able to detect traces of gluten that might be hiding somewhere else on your plate.
    While the product would have its limits in this respect, it would give users the ability to detect gluten in many cases.
    Would you want such a tool? Would it be helpful for you?

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