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      Frequently Asked Questions About Celiac Disease   04/24/2018

      This Celiac.com FAQ on celiac disease will guide you to all of the basic information you will need to know about the disease, its diagnosis, testing methods, a gluten-free diet, etc.   Subscribe to Celiac.com's FREE weekly eNewsletter   What is Celiac Disease and the Gluten-Free Diet? What are the major symptoms of celiac disease? Celiac Disease Symptoms What testing is available for celiac disease?  Celiac Disease Screening Interpretation of Celiac Disease Blood Test Results Can I be tested even though I am eating gluten free? How long must gluten be taken for the serological tests to be meaningful? The Gluten-Free Diet 101 - A Beginner's Guide to Going Gluten-Free Is celiac inherited? Should my children be tested? Ten Facts About Celiac Disease Genetic Testing Is there a link between celiac and other autoimmune diseases? Celiac Disease Research: Associated Diseases and Disorders Is there a list of gluten foods to avoid? Unsafe Gluten-Free Food List (Unsafe Ingredients) Is there a list of gluten free foods? Safe Gluten-Free Food List (Safe Ingredients) Gluten-Free Alcoholic Beverages Distilled Spirits (Grain Alcohols) and Vinegar: Are they Gluten-Free? Where does gluten hide? Additional Things to Beware of to Maintain a 100% Gluten-Free Diet What if my doctor won't listen to me? An Open Letter to Skeptical Health Care Practitioners Gluten-Free recipes: Gluten-Free Recipes
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    DID PRESIDENT JOHN F. KENNEDY SUFFER UNDIAGNOSED CELIAC DISEASE?


    Jefferson Adams

    Celiac.com 03/28/2014 - Did John F. Kennedy suffer from symptoms of undiagnosed celiac disease? Celiac disease expert Dr. Peter H. R. Green says Kennedy's known symptoms and family history make it likely that America's 35th president did in fact have celiac disease, which remained undetected in his lifetime.


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    Photo: Wikimadiea Commons--White House Press OfficeDr. Green is the director of the Celiac Disease Center at Columbia University, professor of clinical medicine at the College of Physicians and Surgeons, Columbia University and attending physician at the Columbia University Medical Center.

    He writes that: “John F. Kennedy’s long-standing medical problems started in childhood. In Kennedy’s adolescence, gastrointestinal symptoms, weight and growth problems as well as fatigue were described. Later in life, he suffered from abdominal pain, diarrhea, weight loss, osteoporosis, migraine and Addison’s disease. Chronic back problems, due to osteoporosis, resulted in several operations and required medications for chronic pain."

    Greene adds that Kennedy’s Irish heritage, history of gastrointestinal complaints since childhood, diagnosis of irritable bowel syndrome and migraine, presence of severe osteoporosis, and the development of Addison’s disease all point to celiac disease.

    Kennedy was given steroids for his problems. Steroid use is associated with the development of osteoporosis and Addison’s disease.

    The occurrence of Addison’s disease in his sister, however, argues for a familial [genetic] cause of his Addison’s disease, rather than an iatrogenic one.

    Source:


    Image Caption: Photo: Wikimadiea Commons--White House Press Office
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    I consider myself an expert on JFK's medical issues having read the Dallek Neobiogrophy of JFK "An Unfinished Life" and having celiac myself. Giving this a medium rating due to the following: 1) It has been as disproved as one can possibly get that JFK had "Addison's Disease" due to: a) his never being tested and found low in lab cortisol; B) his adrenals were examined at autopsy following his Assassination at Bethesda Naval Hospital and found to be perfectly normal in appearance; c) his cortisol levels were tested under the physiologic stress of a back operation in 1955 and found to be absolutely normal--thus no indication of "Addisonian Crisis" as would be expected had the presumptive diagnosis been accurate. That pretty much puts the nail in the coffin of the thesis of "Addison's Disease", which was of course raised by the Nixon campaign in 1960 and denied by the Kennedy campaign (and accurately, despite the neo-critics that claim otherwise). 2) The osteoporosis JFK experienced was due to two factors: 1) His celiac sprue; 2) His daily usage of Corticosteroids from his early twenties until the day he was assassinated at age 46. Now clearly there is a "yin and yang" factor in that:1) The daily steroid usage placed his celiac and other related autoimmune conditions in, more or less, remission, but the side effects worsened his osteoporosis, something well recognized today as a side effect but not in JFK's day, so had he followed a strict gluten free diet instead of taken daily steroids those side effect issues would never have come into play;2) He left some of his corticosteroids home on a trip to England once and thus he was without this for a few days, which merely tripped a destabilzation of the homeostatic mechanism that resulted in underproduction of cortisol from the adrenals as a normal consequence of adjusting by the body to daily steroid use--yet in no way did this, as is commonly presumed and incorrectly so, reflect "Addison's Disease". Now, the current consensus medically is (thankfully, because Addison's theory is BUNK)he suffered something called Autoimmune Polyendocrine Syndrome Type II, which can encompass Celiac by definition(albeit that designation rather puts the Celiac on the back burner, which is in my judgment a disservice to medical history). That was designated to explain and focus on pain syndromes and his treatment by contemporary physicians of his day who treated him, notably Dr. Janet Travell. In this manner, medicine can now say something to the effect of "what a brilliant job it did in managing JFK's pain syndromes", yet what clearly WAS iatrogenic was his back pain and the extent of that from surgeries that did more harm than good and the daily steroid use is something that was experimental in his day, knocked back his autoimmune diseases, yet produced some side effects such that no physician today would ever believe in prescribing for that length of time for anything other than an immediate life-threatening emergency. The Addison's Disease thesis provided a basis upon which to BELIEVE he always had a life threatening emergency but this clearly was not the case, although celiac is nothing to sneeze at and clearly led to malnutritive conditions including the osteomalacia and bone loss associated therewith. The bottom line here is that many articles attempting to describe JFK's medical conditions fall short by falling into common pitfalls in delivering maximum elucidation to his obvious autoimmune syndromes which included celiac and Hashimoto's and likely ulcerative colitis, and the complications created thereto by his medical treatment. Yes, I do think we can reasonably add the treatment of pain having some skill involved in this, but of course this would not have been needed had the celiac sprue education series been inculcated into his medical treatment and understanding, and thus, would have saved him much pain, and might, as one physician put it, have enabled him to survive the assassination at the hands of Oswald shooting a rifle had he not have been wearing a back brace as a result. We will never know this of course, but what we can note is that the complications of the medical misunderstandings of his day led to a specific course of care that walked down a road that was unnecessary and painful in terms of surgeries, and to this day the medical profession has not come clean as to exactly why and where it goofed on his medical care, as if the medical profession is almost like the Kennedy family itself, reluctant at best to admit failures in care and reluctant at best to admit gaps in knowledge related to its own longstanding avoidance of understanding, coming to grips with, and relating professionally to the issue of celiac disease especially with respect to deliverance of maximum patient service.

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    Guest Maria

    Posted

    President John F. Kennedy did not have celiac disease even though some people were trying to give it to him before he was killed. making themselves look like what?

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    Before I reply directly to Maria's comment (and I hope this is not Maria Shriver, who was related to the Kennedy Clan and married for awhile to the longtime Governor of "Cullyfornia", the ex-bodybuilder/ex-actor Arnold Schwarzenegger--in which case we have some family bias going on here), I will point out that Maria's comment here reflects the frenzical mythology surrounding the life of JFK. JFK was merely a man--but we seem to want to either reduce him to a philandering pervert or a Godly Mythical figure. And there is really no serious doubt he had celiac sprue at this point---view pictures of him as a child and young man and the emaciation is readily apparent. The steroids put some spark in his sex life he otherwise would never have experienced. And how is it with celiac men today, who do not have the benefit of long term treatment with steroids? Don't make me comment on THIS!! The "Cullyfornians" in particular would go Priestly and Cardinally and Bishoply and Nunly WILD!! Thank you!! As for former Governor S, I can only say on here....."I'll be BECK!!"

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    Jefferson Adams
    Celiac.com 04/19/2018 - Previous genome and linkage studies indicate the existence of a new disease triggering mechanism that involves amino acid metabolism and nutrient sensing signaling pathways. In an effort to determine if amino acids might play a role in the development of celiac disease, a team of researchers recently set out to investigate if plasma amino acid levels differed among children with celiac disease compared with a control group.
     
    The research team included Åsa Torinsson Naluai, Ladan Saadat Vafa, Audur H. Gudjonsdottir, Henrik Arnell, Lars Browaldh, and Daniel Agardh. They are variously affiliated with the Institute of Biomedicine, Department of Microbiology & Immunology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; the Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden; the Department of Pediatric Gastroenterology, Hepatology and Nutrition, Karolinska University Hospital and Division of Pediatrics, CLINTEC, Karolinska Institute, Stockholm, Sweden; the Department of Clinical Science and Education, Karolinska Institute, Sodersjukhuset, Stockholm, Sweden; the Department of Mathematical Sciences, Chalmers University of Technology, Gothenburg, Sweden; the Diabetes & Celiac Disease Unit, Department of Clinical Sciences, Lund University, Malmö, Sweden; and with the Nathan S Kline Institute in the U.S.A.
    First, the team used liquid chromatography-tandem mass spectrometry (LC/MS) to analyze amino acid levels in fasting plasma samples from 141 children with celiac disease and 129 non-celiac disease controls. They then crafted a general linear model using age and experimental effects as covariates to compare amino acid levels between children with celiac disease and non-celiac control subjects.
    Compared with the control group, seven out of twenty-three children with celiac disease showed elevated levels of the the following amino acids: tryptophan; taurine; glutamic acid; proline; ornithine; alanine; and methionine.
    The significance of the individual amino acids do not survive multiple correction, however, multivariate analyses of the amino acid profile showed significantly altered amino acid levels in children with celiac disease overall and after correction for age, sex and experimental effects.
    This study shows that amino acids can influence inflammation and may play a role in the development of celiac disease.
    Source:
    PLoS One. 2018; 13(3): e0193764. doi: & 10.1371/journal.pone.0193764