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    View's Elisabeth Hasselbeck Shares Gluten-free Odyssey in New Book


    Jefferson Adams

    Celiac.com 05/06/2009 - Like so many people with celiac disease, Elisabeth Hasselbeck of ABC's The View has a story to tell. Like so many people with celiac disease, that story involves a long, slow, painful journey from suffering to understanding, to self-empowerment and recovery. In between were periods of confusion, doubt, isolation and malaise. Hasselbeck describes that journey in her new book: The gluten-free Diet: A Gluten-Free Survival Guide.


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    The G-FreeDiet:A Gluten-Free Survival GuideHasselbeck's odyssey began during her sophomore year of college, when she fell ill after returning from a three-week-long trip to Belize. She was diagnosed with a severe bacterial intestinal infection which, her doctor said, was a result of her travels in Central America. The illness put in the school infirmary for nearly a week, with an immensely distended belly and a 103+ fever. Once the initial infection subsided, she was naturally relieved, and thought the worst was over. Little did she know that a long road lay ahead.

    As an athlete, Hasselbeck was eager to get back into shape after she was discharged. Her body had other ideas. During this period, she says she felt absolutely ravenous, yet the only dining hall foods that seemed appealing were soft-serve vanilla frozen yogurt and Rice Krispies. Food had lost its appeal.

    Hasselbeck grew up in an Italian-American neighborhood in Providence, RI, in a family that prized all things bread and pasta, so she wasn't about to give up the appetite and food battle without a fight.

    However, no matter what she ate nothing satisfied her hunger—and everything seemed to upset her stomach. After nearly every meal, she had the classic bloating, and sharp, gassy pains in her gut that are all too familar to most celiacs. Cramps, indigestion and diarrhea were familiar companions; sometimes all at once. Often, she would become too tired to move.

    It was about this time that she became a contestant on Survivor: The Australian Outback. While enduring the trials of surviving in the outback, Hasselbeck was deprived of her normal, gluten-rich American diet, and forced to subsist on things she would never willingly eat at home. Yet, her symptoms were gone, and she had never felt better. Once she returned to the U.S., she narrowed the scope of her quest. She eliminated nearly everything from her diet and introduced items one at a time.

    After nearly forty days basically starving herself, she sought solace in her pre-Australia diet, with dire consequences. After the joy of knowing a healthy, happy gut for the first time in years, she suddenly found herself feeling worse than ever, and spending days in her room, bedridden, save for urgent trips to the bathroom.

    She saw a doctor and received a diagnosis of "irritable bowel syndrome." Suspicious of what she saw as an acknowledgement of symptoms masquerading as a diagnosis, she began to look for connections on her own.

    Fortunately for Hasselbeck, she began to make a connection between the illness she had suffered for so long and the food she was eating. She noticed that when ate starchy foods, her symptoms returned with a vengeance.

    An Internet search told her that she might be suffering an adverse reaction to wheat. She quickly moved to eliminate wheat from her diet. Her experience, as so many with celiac disease know all too well, was an educational one, filled with occasional episodes that left her feeling inexplicably ill.

    Unable to figure out exactly what was making her sick, she undertook more research and stumbled upon some information about gluten intolerance and celiac disease.

    In 2002, after five years of suffering, Hasselbeck diagnosed diagnosed herself with celiac disease, an autoimmune condition triggered by gluten, the protein found in wheat, rye and barley.

    Elizabeth Hasselbeck is Gluten-FreeCeliac disease can cause acute damage to the small intestine and the digestive system, and, left untreated, it can leave sufferers at risk for certain types of cancer and other associated conditions. The only known treatment is a lifelong diet free from wheat rye and barley gluten. Once she realized what had been tormenting her for so many long, she set about eliminating all wheat, barley, oats, and rye from her diet.

    Still, even after she made her diagnosis, she faced a long line of skeptical doctors. In fact, it was eight years after her symptoms first began until she found a doctor who was willing to listen, and who had answers.

    Her move  to New York City put her into contact with Dr. Peter Green, the director of the Celiac Disease Center at Columbia University, who confirmed what she'd suspected for years: Elisabeth Hasselbeck has celiac disease. After waiting for years for a sensible explanation to her symptoms, Dr. Green was the first doctor to look for the cause, not simply to treat the symptoms. Despite the same mistakes and accidents that most of us celiacs have also experienced, her perseverance paid off in the end and she remains gluten-free to this day.

    You can watch Elisabeth Hasselbeck daily on ABC.com's The View. Hasselbeck's book is now available at Celiac.com.

    Source: ABC News

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    Guest Linda

    Posted

    Elizabeth Hasselbeck is trying to get attention. Her story is no different than thousand of others.

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    Guest Beth

    Posted

    Lucky for us that Elisabeth Hasselbeck will use her post on national TV and as a celebrity to educate about celiac! That's just the kind of attention we all need -- maybe including you, too, Linda.

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    Guest Morrie Cutler

    Posted

    Very good. I have had celiac all my life but just found out less then 2 years ago and it changed me....

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    Guest Carol

    Posted

    I was interested to read this. My daughter developed celiac this same way, after an Ecoli infection.

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    Guest Maureen

    Posted

    The only good thing about her book is that she is bringing awareness to celiac disease in a good way. The bad news it that there are several inaccuracies in the book. Anyone who turns this into a fad diet needs their head examined. A gluten free diet is not a choice but a must for anyone with Celiac disease or gluten sensitivity.

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    Guest Robena Lasley

    Posted

    So, Elisabeth is getting a little free promotion for her book. Who the heck cares, we who suffer celiac disease, are also getting more awareness for the disease. That can't be a bad thing!

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    Guest Laura V. Kaplan

    Posted

    I don't care how Elizabeth gets her message out there I think its great. I have had a lot of stomach and GI problems all my life so its nice to finally here from someone who is getting results . You go girl.

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    Guest Dawn

    Posted

    OOOH Linda... bitter much? If a celebrity brings the topic of celiac disease to the public... and it makes it easier to find help when we're in restaurants and grocery stores... then how can it be bad? We should thank her, rather than slam her.

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    Guest Erin

    Posted

    I CAN NOT stand Elizabeth, BUT, I second Dawn in saying that if it brings more options for us to restaurants and grocery stores, more power to her!

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    Guest Elizabeth Campbell Duke

    Posted

    I, the heck, care! It was by watching 'The View' that my husband and I finally put 2 and 2 together. He is 54, suffers from Rheumatoid Arthritis... and we knew something else was wrong. I told him when I met him 5 or 6 years ago that he has been under-diagnosed and ineffectively treated for the last 30 years. He had his blood test today (after having to eat gluten for an agonizing week), and we don't care about getting positive confirmation from an endoscopy. Gluten is out of our house thanks to Elisabeth and 'The View'.

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    Guest karen

    Posted

    I saw the interview with Elisabeth and I have to say I'm glad that celiac is finally getting a voice but she kept referring to celiac as an allergy to wheat which it's not. Let's hope with this new found attention, celiac will finally be diagnosed quicker.

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    I have mixed feelings about Elisabeth. I have two sons that are struggling with Celiac. They were diagnosed 5 months ago. We are all struggling as a family. I am glad she is bringing attention to the public and people are more aware of the disease. On the other hand she makes it look so simple during her interview. It is not as simple as she makes it sound. It is actually very difficult and frustrating

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    Guest Karen

    Posted

    WOW! First I must say most of the people that have left comments here are NO DOUBT, miserable hating people, maybe that's why you don't feel well. Elisabeth has brought awareness to people such as myself. I would have never known about Celia disease. THANK YOU ELISABETH.

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    Guest Cheryl Patton Gantt

    Posted

    Elisabeth, I have been in agony for a long time with, irritable bowel syndrome, I knew I had celiac but the doctors would not listen. This past week I had an upper endoscopy and a colonoscopy - before this a blood test confirmed celiac FINALLY!!! In 2006 and last week 6-22-09 both upper endoscopies did not show it however, the surgeons told me right after the scope. It looks like they would have to send something off to a lab to be cultured or tested??? The only reason I found out that a previous blood test confirmed it was I was there on 6-10-09, they drew blood, then my surgeon went out of town! So...another surgeon did my scopes. As he was telling me that he didn't find celiac and he was flipping through my chart - I saw the lab result underlined!!!! Well, I called the nurses attention to it and the surgeon was already busy so I have to wait until 7-30-09 to talk to my regular MD about it!!! This is so frustrating! My taste buds have gone and I crave only sweet stuff that I shouldn't eat - like honey buns and I eat - get this a lot of oatmeal!! I am recently divorced and have no time for myself - had to take time off work to get scopes. I knew oats weren't good but it is quick and I get up @ 4 am to go to work. I hope I can get your book. Thank you if you do read this.

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    Guest Brittney Daniel

    Posted

    Thank goodness for celebrities, such as Elisabeth Hasselbeck, who are willing to share their private struggles and ailments for the sake of all who suffer a similar fate. They clearly risk much by doing so in our media-frenzy society. I'm puzzled by some of the negative, anti-Elisabeth comments, however. Bitterness, jealousy and a victim mentality do not support good health. A healthy emotional and mental attitude, in combination with wholesome diet, exercise and nutritional supplements encourage the immune system into new found health. It takes time and diligence. Success won't be achieved by a few weeks of diet focus followed by dietary cheating. It is what it is: a lifestyle change.

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    I just saw Elisabeth's interview late last night on Joy Behar's show which I NEVER watch. I didn't change the channel because I saw Elisabeth and think she is delightful to watch and listen to. I LOVED her on Survivor and watch 'The View' sometimes, only because of her; and yes, I am a republican too and very proud of it!!!

    Anyway, I about fell out of my chair as I listened to her talk about celiac disease. I had never heard of it.

    I have a darling niece who has been suffering for years with stomach problem and a light came on as I heard some of Elisabeth's symptoms. I wanted to call my sister right then and have her watch but it was to late.

    My sister was so excited when I called her this morning and told her about it and she is calling her daughter this very minute to pass on the information. I will be surprised if this isn't what she has been suffering from for all these years. This poor, sweet girl has been through test after test only to be told " nothing is wrong". She would come home from high school and lay doubled up in pain with tears in her eyes. She's always been a tinny little thing, with a ravenous appetite but she has had to starve herself because anything she eats makes her so sick.

    After High School she graduated from cosmetology school and started working, in pain. She spent 18 months on a mission for our church, in pain. She just got married a few months ago and has been trying to be the perfect bride, in pain. Oh how I hope this is finally the answer she has been looking for! Thank you Elisabeth for putting a face on something so frustrating and almost impossible to diagnose. I now LOVE you even more.

     

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    Elizabeth Hasselbeck is trying to get attention. Her story is no different than thousand of others.

    I find it so funny that people can't put their hatred aside for someone even if that person is shedding light on a condition that desperately needs more attention. Let me guess, Linda...you don't like her political opinions. Get over it. She's getting more people to talk about the disease, and that's a wonderful thing.

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    I find it so funny that people can't put their hatred aside for someone even if that person is shedding light on a condition that desperately needs more attention. Let me guess, Linda...you don't like her political opinions. Get over it. She's getting more people to talk about the disease, and that's a wonderful thing.

    Amen, Lew.

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    My 21 year old daughter was diag. with Celiac 20 years ago at Walter Reed Army Med. Ct. At the time (1991) Celiac was virtually unheard of and very little information, even through a nutritionist, was available. Through the years I have learned as I went along; doctors and nutritionists have been able to provide me with much more information as well. There is so much more known today (2010) about celiac sprue. I am always happily surprised when I go into a grocery store and see the words "Gluten Free" marked on a product. FYI...just because a product says it may be wheat free, does not make it gluten free. READ THE LABELS!!!

    Thank you Elisabeth for helping bring attention to celiac and the term "gluten free"!!!

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    Guest Karon

    Posted

    Help. I've been diagnosed with IBS and acid reflux disease. But nothing is helping... How can I get this tested? They did an endo and upper scope wouldn't this have shown celiac?

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    My issue with Elisabeth's celiac claims are that she consistently says it's an allergy and calls it a lifestyle which makes it sound like some sort of elective way of living. Self-diagnosis of celiac can be dangerous. If you feel better not eating gluten then don't eat it but don't go around calling yourself celiac w/o blood tests and a biopsy. Going gluten-free is HARD and NOT an allergy. For some it may only be wheat issue or some other component in the food one is consuming. But having said all that bringing attention to celiac and gluten issues in general is a good thing. But don't self-diagnose and eliminate foods that do have nutritional benefits if you don't need to. Many gluten-free foods do not have the same nutritional value as conventional foods and can be much more expensive.

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    Guest admin

    Posted

    My issue with Elisabeth's celiac claims are that she consistently says it's an allergy and calls it a lifestyle which makes it sound like some sort of elective way of living. Self-diagnosis of celiac can be dangerous. If you feel better not eating gluten then don't eat it but don't go around calling yourself celiac w/o blood tests and a biopsy. Going gluten-free is HARD and NOT an allergy. For some it may only be wheat issue or some other component in the food one is consuming. But having said all that bringing attention to celiac and gluten issues in general is a good thing. But don't self-diagnose and eliminate foods that do have nutritional benefits if you don't need to. Many gluten-free foods do not have the same nutritional value as conventional foods and can be much more expensive.

    It sounds like you didn't read her book...she did get diagnosed, and recommends that people get tested and diagnosed.

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    Guest admin

    Posted

    My issue with Elisabeth's celiac claims are that she consistently says it's an allergy and calls it a lifestyle which makes it sound like some sort of elective way of living. Self-diagnosis of celiac can be dangerous. If you feel better not eating gluten then don't eat it but don't go around calling yourself celiac w/o blood tests and a biopsy. Going gluten-free is HARD and NOT an allergy. For some it may only be wheat issue or some other component in the food one is consuming. But having said all that bringing attention to celiac and gluten issues in general is a good thing. But don't self-diagnose and eliminate foods that do have nutritional benefits if you don't need to. Many gluten-free foods do not have the same nutritional value as conventional foods and can be much more expensive.

    It sounds like you didn't read her book...she did get diagnosed, and recommends that people get tested and diagnosed.

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    I'm SO thankful that I saw Elisabeth talking about celiac disease on the view. I'd never heard of it till then and for 3 years doctors told me I just had IBS. I told my new doctor about how I had all the symptoms and he ordered me a blood test and sure enough I have celiac. Elisabeth is amazing! She's raising awareness for a disease not many people are familiar with and helping people with her book!

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    Sounds way too familiar. I self-diagnosed in May, 2011 and was shocked at how well I felt. Now at age 54, I just wish I had found it earlier. I feel like I missed around a decade of decent life.

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    With the advent of the Internet a whole new field of anecdotal information was emerging, connecting a variety of neurological symptoms to celiac disease. While many medical practitioners and researchers were casting aspersions on these assertions, a select few chose to explore such claims using scientific research designs and methods. While connections between stuttering and gluten consumption seem to have been overlooked by the medical research community, there is a rich literature on the Internet that cries out for more structured investigation of this connection. Conversely, perhaps a publication bias of the peer review process excludes work that explores this connection.
    Whatever the reason that stuttering has not been reported in the medical literature in association with gluten ingestion, a number of personal disclosures and comments suggesting a connection between gluten and stuttering can be found on the Internet. Abid Hussain, in an article about food allergy and stuttering said: “The most common food allergy prevalent in stutterers is that of gluten which has been found to aggravate the stutter” (10). Similarly, Craig Forsythe posted an article that includes five cases of self-reporting individuals who believe that their stuttering is or was connected to gluten, one of whom also experiences stuttering from foods containing yeast (11). The same site contains one report of a stutterer who has had no relief despite following a gluten free diet for 20 years (11). Another stutterer, Jay88, reports the complete disappearance of her/his stammer on a gluten free diet (12). Doubtless there are many more such anecdotes to be found on the Internet* but we have to question them, exercising more skepticism than we might when reading similar claims in a peer reviewed scientific or medical journal.
    There are many reports in such journals connecting brain and neurological ailments with gluten, so it is not much of a stretch, on that basis alone, to suspect that stuttering may be a symptom of the gluten syndrome. Rodney Ford has even characterized celiac disease as an ailment that may begin through gluten-induced neurological damage (13) and Marios Hadjivassiliou and his group of neurologists and neurological investigators have devoted considerable time and effort to research that reveals gluten as an important factor in a majority of neurological diseases of unknown origin (14) which, as I have pointed out previously, includes most neurological ailments.
    My own experience with stuttering is limited. I stuttered as a child when I became nervous, upset, or self-conscious. Although I have been gluten free for many years, I haven’t noticed any impact on my inclination to stutter when upset. I don’t know if they are related, but I have also had challenges with speaking when distressed and I have noticed a substantial improvement in this area since removing gluten from my diet. Nonetheless, I have long wondered if there is a connection between gluten consumption and stuttering. Having done the research for this article, I would now encourage stutterers to try a gluten free diet for six months to see if it will reduce or eliminate their stutter. Meanwhile, I hope that some investigator out there will research this matter, publish her findings, and start the ball rolling toward getting some definitive answers to this question.
    Sources:
    1. Toft M, Dietrichs E. Aggravated stuttering following subthalamic deep brain stimulation in Parkinson’s disease--two cases. BMC Neurol. 2011 Apr 8;11:44.
    2. Tani T, Sakai Y. Stuttering after right cerebellar infarction: a case study. J Fluency Disord. 2010 Jun;35(2):141-5. Epub 2010 Mar 15.
    3. Lundgren K, Helm-Estabrooks N, Klein R. Stuttering Following Acquired Brain Damage: A Review of the Literature. J Neurolinguistics. 2010 Sep 1;23(5):447-454.
    4. Jäncke L, Hänggi J, Steinmetz H. Morphological brain differences between adult stutterers and non-stutterers. BMC Neurol. 2004 Dec 10;4(1):23.
    5. Kell CA, Neumann K, von Kriegstein K, Posenenske C, von Gudenberg AW, Euler H, Giraud AL. How the brain repairs stuttering. Brain. 2009 Oct;132(Pt 10):2747-60. Epub 2009 Aug 26.
    6. Galantucci S, Tartaglia MC, Wilson SM, Henry ML, Filippi M, Agosta F, Dronkers NF, Henry RG, Ogar JM, Miller BL, Gorno-Tempini ML. White matter damage in primary progressive aphasias: a diffusion tensor tractography study. Brain. 2011 Jun 11.
    7. Lundgren K, Helm-Estabrooks N, Klein R. Stuttering Following Acquired Brain Damage: A Review of the Literature. J Neurolinguistics. 2010 Sep 1;23(5):447-454.
    8. [No authors listed] Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 43-1988. A 52-year-old man with persistent watery diarrhea and aphasia. N Engl J Med. 1988 Oct 27;319(17):1139-48
    9. Molteni N, Bardella MT, Baldassarri AR, Bianchi PA. Celiac disease associated with epilepsy and intracranial calcifications: report of two patients. Am J Gastroenterol. 1988 Sep;83(9):992-4.
    10. http://ezinearticles.com/?Food-Allergy-and-Stuttering-Link&id=1235725 
    11. http://www.craig.copperleife.com/health/stuttering_allergies.htm 
    12. https://www.celiac.com/forums/topic/73362-any-help-is-appreciated/
    13. Ford RP. The gluten syndrome: a neurological disease. Med Hypotheses. 2009 Sep;73(3):438-40. Epub 2009 Apr 29.
    14. Hadjivassiliou M, Gibson A, Davies-Jones GA, Lobo AJ, Stephenson TJ, Milford-Ward A. Does cryptic gluten sensitivity play a part in neurological illness? Lancet. 1996 Feb 10;347(8998):369-71.

    Jefferson Adams
    Celiac.com 06/14/2018 - Refractory celiac disease type II (RCDII) is a rare complication of celiac disease that has high death rates. To diagnose RCDII, doctors identify a clonal population of phenotypically aberrant intraepithelial lymphocytes (IELs). 
    However, researchers really don’t have much data regarding the frequency and significance of clonal T cell receptor (TCR) gene rearrangements (TCR-GRs) in small bowel (SB) biopsies of patients without RCDII. Such data could provide useful comparison information for patients with RCDII, among other things.
    To that end, a research team recently set out to try to get some information about the frequency and importance of clonal T cell receptor (TCR) gene rearrangements (TCR-GRs) in small bowel (SB) biopsies of patients without RCDII. The research team included Shafinaz Hussein, Tatyana Gindin, Stephen M Lagana, Carolina Arguelles-Grande, Suneeta Krishnareddy, Bachir Alobeid, Suzanne K Lewis, Mahesh M Mansukhani, Peter H R Green, and Govind Bhagat.
    They are variously affiliated with the Department of Pathology and Cell Biology, and the Department of Medicine at the Celiac Disease Center, New York Presbyterian Hospital/Columbia University Medical Center, New York, USA. Their team analyzed results of TCR-GR analyses performed on SB biopsies at our institution over a 3-year period, which were obtained from eight active celiac disease, 172 celiac disease on gluten-free diet, 33 RCDI, and three RCDII patients and 14 patients without celiac disease. 
    Clonal TCR-GRs are not infrequent in cases lacking features of RCDII, while PCPs are frequent in all disease phases. TCR-GR results should be assessed in conjunction with immunophenotypic, histological and clinical findings for appropriate diagnosis and classification of RCD.
    The team divided the TCR-GR patterns into clonal, polyclonal and prominent clonal peaks (PCPs), and correlated these patterns with clinical and pathological features. In all, they detected clonal TCR-GR products in biopsies from 67% of patients with RCDII, 17% of patients with RCDI and 6% of patients with gluten-free diet. They found PCPs in all disease phases, but saw no significant difference in the TCR-GR patterns between the non-RCDII disease categories (p=0.39). 
    They also noted a higher frequency of surface CD3(−) IELs in cases with clonal TCR-GR, but the PCP pattern showed no associations with any clinical or pathological feature. 
    Repeat biopsy showed that the clonal or PCP pattern persisted for up to 2 years with no evidence of RCDII. The study indicates that better understanding of clonal T cell receptor gene rearrangements may help researchers improve refractory celiac diagnosis. 
    Source:
    Journal of Clinical Pathologyhttp://dx.doi.org/10.1136/jclinpath-2018-205023

    Jefferson Adams
    Celiac.com 06/13/2018 - There have been numerous reports that olmesartan, aka Benicar, seems to trigger sprue‐like enteropathy in many patients, but so far, studies have produced mixed results, and there really hasn’t been a rigorous study of the issue. A team of researchers recently set out to assess whether olmesartan is associated with a higher rate of enteropathy compared with other angiotensin II receptor blockers (ARBs).
    The research team included Y.‐H. Dong; Y. Jin; TN Tsacogianis; M He; PH Hsieh; and JJ Gagne. They are variously affiliated with the Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School in Boston, MA, USA; the Faculty of Pharmacy, School of Pharmaceutical Science at National Yang‐Ming University in Taipei, Taiwan; and the Department of Hepato‐Gastroenterology, Chi Mei Medical Center in Tainan, Taiwan.
    To get solid data on the issue, the team conducted a cohort study among ARB initiators in 5 US claims databases covering numerous health insurers. They used Cox regression models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for enteropathy‐related outcomes, including celiac disease, malabsorption, concomitant diagnoses of diarrhea and weight loss, and non‐infectious enteropathy. In all, they found nearly two million eligible patients. 
    They then assessed those patients and compared the results for olmesartan initiators to initiators of other ARBs after propensity score (PS) matching. They found unadjusted incidence rates of 0.82, 1.41, 1.66 and 29.20 per 1,000 person‐years for celiac disease, malabsorption, concomitant diagnoses of diarrhea and weight loss, and non‐infectious enteropathy respectively. 
    After PS matching comparing olmesartan to other ARBs, hazard ratios were 1.21 (95% CI, 1.05‐1.40), 1.00 (95% CI, 0.88‐1.13), 1.22 (95% CI, 1.10‐1.36) and 1.04 (95% CI, 1.01‐1.07) for each outcome. Patients aged 65 years and older showed greater hazard ratios for celiac disease, as did patients receiving treatment for more than 1 year, and patients receiving higher cumulative olmesartan doses.
    This is the first comprehensive multi‐database study to document a higher rate of enteropathy in olmesartan initiators as compared to initiators of other ARBs, though absolute rates were low for both groups.
    Source:
    Alimentary Pharmacology & Therapeutics

    Jefferson Adams
    Celiac.com 06/12/2018 - A life-long gluten-free diet is the only proven treatment for celiac disease. However, current methods for assessing gluten-free diet compliance are lack the sensitivity to detect occasional dietary transgressions that may cause gut mucosal damage. So, basically, there’s currently no good way to tell if celiac patients are suffering gut damage from low-level gluten contamination.
    A team of researchers recently set out to develop a method to determine gluten intake and monitor gluten-free dietary compliance in patients with celiac disease, and to determine its correlation with mucosal damage. The research team included ML Moreno, Á Cebolla, A Muñoz-Suano, C Carrillo-Carrion, I Comino, Á Pizarro, F León, A Rodríguez-Herrera, and C Sousa. They are variously affiliated with Facultad de Farmacia, Departamento de Microbiología y Parasitología, Universidad de Sevilla, Sevilla, Spain; Biomedal S.L., Sevilla, Spain; Unidad Clínica de Aparato Digestivo, Hospital Universitario Virgen del Rocío, Sevilla, Spain; Celimmune, Bethesda, Maryland, USA; and the Unidad de Gastroenterología y Nutrición, Instituto Hispalense de Pediatría, Sevilla, Spain.
    For their study, the team collected urine samples from 76 healthy subjects and 58 patients with celiac disease subjected to different gluten dietary conditions. To quantify gluten immunogenic peptides in solid-phase extracted urines, the team used a lateral flow test (LFT) with the highly sensitive and specific G12 monoclonal antibody for the most dominant GIPs and an LFT reader. 
    They detected GIPs in concentrated urines from healthy individuals previously subjected to gluten-free diet as early as 4-6 h after single gluten intake, and for 1-2 days afterward. The urine test showed gluten ingestion in about 50% of patients. Biopsy analysis showed that nearly 9 out of 10 celiac patients with no villous atrophy had no detectable GIP in urine, while all patients with quantifiable GIP in urine showed signs of gut damage.
    The ability to use GIP in urine to reveal gluten consumption will likely help lead to new and non-invasive methods for monitoring gluten-free diet compliance. The test is sensitive, specific and simple enough for clinical monitoring of celiac patients, as well as for basic and clinical research applications including drug development.
    Source:
    Gut. 2017 Feb;66(2):250-257.  doi: 10.1136/gutjnl-2015-310148.