Celiac.com Sponsor (A1):


Join eNewsletter


Celiac.com Sponsor (A1-m):



Join eNewsletter
  • Join Our Community!

    Ask us a question in our celiac / gluten-free forum.

  • Scott Adams

    Non-Celiac Gluten Sensitivity Common in Patients with Refractory Functional Dyspepsia

    Scott Adams
    0
    Reviewed and edited by a celiac disease expert.

      What can a new study tell us about non-celiac gluten sensitivity in patients with refractory functional dyspepsia?


    The gate of the National Garden, Tehran, Iran. Image: CC BY 2.0--sibo
    Caption: The gate of the National Garden, Tehran, Iran. Image: CC BY 2.0--sibo

    Celiac.com 07/09/2020 - Refractory functional dyspepsia (RFD) is a condition marked by ongoing symptoms even with medical treatment or H. pylori eradication. A team of researchers recently set out to investigate the presence of gluten-dependent RFD as a clinical presentation of Non-Celiac Gluten Sensitivity (NCGS). 

    The team included Bijan Shahbazkhani, Mohammad M. Fanaeian, Mohammad J. Farahvash, Najmeh Aletaha, Foroogh Alborzi, Luca Elli, Amirhossein Shahbazkhani, Jayran Zebardast, and Mohammad Rostami-Nejad.



    Celiac.com Sponsor (A12):






    Celiac.com Sponsor (A12-m):




    They are variously associated with Division of Gastroenterology and Liver Diseases, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran; the Division of Gastroenterology and Liver Diseases, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran; the Center for Prevention and Diagnosis of Celiac Disease, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; the Cognitive Science Special Linguistics, Institute of Cognitive Sciences, Tehran, Iran; and the Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

    For six weeks, the team followed the progress of RFD patients on a gluten-free diet. All patients had been checked and ruled out for celiac disease, wheat allergy and H. pylori infection. 

    The team used visual analogue scales to gauge symptoms. Patients who reported a 30% or better improvement, in at least one symptom after a gluten-free diet, then faced a double-blind placebo controlled gluten challenge. 

    For the study, the research team divided the participants randomly into two groups. They assessed symptoms after the gluten/placebo challenge. They also followed those who responded to a gluten-free diet for another 3 months, to assess the relationship between patient symptoms and gluten consumption. 

    Out the seventy-seven patients with RFD, fifty patients, or 65%, failed to respond to a gluten-free diet. Twenty-seven patients, more than one-third, reported that a gluten-free diet improved their gastrointestinal symptoms. Five patients with RFD, and 14 patients who responded to gluten-free diet, experienced a recurrence of symptoms after blind gluten ingestion, which indicates Non-Celiac Gluten Sensitivity. 

    Symptoms that improved in Non-Celiac Gluten Sensitivity patients on a gluten-free diet include extra-intestinal symptoms, fatigue and weakness, musculo-skeletal pain, and headache. 

    Because of the high rates of Non-Celiac Gluten Sensitivity among RFD patients, the research team advocates the use of a diagnostic/therapeutic roadmap to evaluate the effect of gluten-free diet in patients with RFD.

    Read more at Sci Rep. 2020; 10: 2401

    Edited by Scott Adams

    0

    User Feedback

    Recommended Comments

    There are no comments to display.



    Join the conversation

    You are posting as a guest. If you have an account, sign in now to post with your account.
    Note: Your post will require moderator approval before it will be visible.

    Guest
    Add a comment...

    ×   Pasted as rich text.   Restore formatting

      Only 75 emoji are allowed.

    ×   Your link has been automatically embedded.   Display as a link instead

    ×   Your previous content has been restored.   Clear editor

    ×   You cannot paste images directly. Upload or insert images from URL.


  • About Me

    Scott Adams was diagnosed with celiac disease in 1994, and, due to the nearly total lack of information available at that time, was forced to become an expert on the disease in order to recover. In 1995 he launched the site that later became Celiac.com to help as many people as possible with celiac disease get diagnosed so they can begin to live happy, healthy gluten-free lives.  He is co-author of the book Cereal Killers, and founder and publisher of the (formerly paper) newsletter Journal of Gluten Sensitivity. In 1998 he founded The Gluten-Free Mall which he sold in 2014. Celiac.com does not sell any products, and is 100% advertiser supported.


  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):





    Celiac.com Sponsors (A17-m):




  • Related Articles

    Scott Adams
    Bardella MT, Minoli G, Ravizza D, et al Arch Intern Med. 2000 May 22;160(10):1489-91
    (Celiac.com 07/09/2000) Approximately 30% to 40% of patients with celiac disease (which affects at least 1 in 200 individuals) also have symptoms of dyspepsia. There is, however, a lack of data regarding the prevalence of celiac disease in patients with dyspepsia.
    Methods: All outpatients who underwent an endoscopy of the upper gastrointestinal tract for dyspepsia were enrolled at our center between January and June 1998. All patients under 12 years old were excluded, as were all patients who had been diagnosed with other gastrointestinal diseases, were...

    Jefferson Adams
    Celiac.com 08/09/2016 - Some researchers have suggested that gluten may not be the actual trigger of symptoms in non-celiac gluten sensitivity. Others feel that gluten is definitely the trigger, especially in certain cases.
    A team of researchers recently set out to evaluate patients with clinical non-celiac gluten sensitivity (NCGS), who presented with lymphocytic enteritis, positive celiac genetics and negative celiac blood tests. The team felt that the results would confirm that gluten is, in fact, the trigger of symptoms in this subgroup of patients.
    The research team included M Rosinach, F Fernández-Bañares, A Carrasco, M Ibarra, R Temiño, A...

    Jefferson Adams
    Celiac.com 08/23/2017 - A team of researchers recently set out to assess how many patients with a diagnosis of non-celiac wheat sensitivity (NCWS) still experienced symptoms of wheat sensitivity after an average follow-up time of 99 months.
    The research team included Antonio Carroccio, Alberto D’Alcamo, Giuseppe Iacono, Maurizio Soresi, Rosario Iacobucci, Andrea Arini, Girolamo Geraci, Francesca Fayer, Francesca Cavataio, Francesco La Blasca, Ada M. Florena, and Pasquale Mansueto.
    Using data collected from 200 participants from a previous study of non-celiac wheat sensitivity, performed between July and December 2016 in Italy, the team found that 1...

    Jefferson Adams
    Celiac.com 01/20/2020 - Researchers have only recently begun to acknowledge that some people without celiac disease nonetheless suffer celiac-like symptoms after eating wheat/gluten, a condition known as non-celiac wheat sensitivity (NCWS), or non-celiac gluten sensitivity (NCGS). A recent study found the first miRNA signatures for the diagnosis of non-celiac wheat sensitivity.
    Imagine how hard it is for some people to get diagnosed with celiac disease, even with the relatively simple antibody tests available. Now imagine having exactly the same symptoms, and not having celiac disease at all. 
    Now, because there are no biomarkers to poi...