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    Jefferson Adams

    NU206 (R-spondin1) Drug Shows Promise in Treating Colitis and Celiac Disease

    Jefferson Adams

    By Jefferson Adams •

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    Reviewed and edited by a celiac disease expert.

    Celiac.com 09/10/2007 - Nuvelo has announced Phase 1 trials of NU206 (R-spondin1) gastrointestinal growth factor product on cancer patients who are receiving radiation or chemotherapy treatment for cancer.


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    NU206 is a recombinant, secreted protein that early animal studies show to act as a highly specific stimulator of the gastrointestinal (GI) epithelial cells. Preclinical studies suggest NU206 promotes growth and regeneration of gastrointestinal tissues in animal models of radiation and chemotherapy treatment for cancer, as well as in animal models of inflammatory bowel disease and short bowel syndrome. They expect to follow shortly thereafter with trials on patients with IBD.

    Mice deficient in IL-10 with drug-inducted colitis serve as research models for human IBD. Studies on such mice show that R-spondin1 substantially prevents mucosal damage and restored mucosal integrity.

    The implications for repairing and preventing mucosal damage in celiac disease are obvious. In addition to restoring other normal mucosal functions, rapid mucosal repair in celiacs through the use of NU206 therapy would provide relief from the problems caused by increased intestinal permeability.

    Gastroenterology. 2007 April; 132(4) pgs 1331-1343

    health writer who lives in San Francisco and is a frequent author of articles for Celiac.com.
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    Guest DELORIS JOHNSON

    Guest DELORIS JOHNSON

    Posted

    RECENTLY DIAGNOSED WITH CELIAC DISEASE, I AM EAGER TO LEARN ALL I CAN, THIS ARTICLE HELPS ME TRY AND UNDERSTAND IT.

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    Guest johnny williams

    Guest johnny williams

    Posted

    I'm currently suffering from colitis, seems like an incredible breakthrough. Look forward to a more natural way to heal. thanks for the info celiac.com for the new info

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    Guest Barbara Coots

    Being 10 years in pain, this sounds great. I am hopeful that we will find a way to help others with bowel disease

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  • About Me

    Jefferson Adams

    Jefferson Adams is Celiac.com's senior writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University, and has authored more than 2,500 articles on celiac disease. His coursework includes studies in science, scientific methodology, biology, anatomy, medicine, logic, and advanced research. He previously served as SF Health News Examiner for Examiner.com, and devised health and medical content for Sharecare.com. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of the book "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.

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