Jump to content



Celiac.com Sponsor (A1):



Celiac.com Sponsor (A1-m):


  • You've found your Celiac Tribe! Join our like-minded, private community and share your story, get encouragement and connect with others.

    💬

    • Sign In
    • Sign Up
  • Record is Archived

    This article is now archived and is closed to further replies.

    Scott Adams
    Scott Adams

    Peptide Discovery Gets To The Guts Of Celiac Disease

    Reviewed and edited by a celiac disease expert.

    July 2000 - Chemistry In Britain
    Summarized by Linda Blanchard



    Celiac.com Sponsor (A12):






    Celiac.com Sponsor (A12-m):




    Celiac.com 01/10/2001 - The article states that Oxford physicians and scientists did an experiment in which celiac patients who were previously on a gluten-free diet were fed a series of human-made peptides that are copies of portions of the peptide chains that are found in the gliadin portion of wheat. The hope was that by feeding those in the study overlapping partial chains, and then testing their blood for T-cells afterward, they could find which specific portion of the wheat protein set off the immune reaction in celiacs.

    One single peptide did trigger the reaction. Now that it has been identified, it is hoped that some solutions to the problems caused by celiac disease may become available. Two approaches seem to involve "turning off" the reaction -- its thought that offering a megadose of the particular peptide might turn the immune reaction off. Another method would involve offering a peptide that was very similar to the offending piece of wheat protein -- but just enough different that it might "turn off" the reaction.

    Another possibility is, of course, genetically modified wheat. It should be possible for scientists to develop a wheat that has a different peptide in the place of the offender, which would hopefully look, taste, and act as wheat does in normal baking without triggering celiac reactions.



    User Feedback

    Recommended Comments

    There are no comments to display.



    Guest
    This is now closed for further comments

  • About Me

    Scott Adams

    Scott Adams was diagnosed with celiac disease in 1994, and, due to the nearly total lack of information available at that time, was forced to become an expert on the disease in order to recover. In 1995 he launched the site that later became Celiac.com to help as many people as possible with celiac disease get diagnosed so they can begin to live happy, healthy gluten-free lives.  He is co-author of the book Cereal Killers, and founder and publisher of the (formerly paper) newsletter Journal of Gluten Sensitivity. In 1998 he founded The Gluten-Free Mall which he sold in 2014. Celiac.com does not sell any products, and is 100% advertiser supported.


  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):





    Celiac.com Sponsors (A17-m):




  • Related Articles

    Scott Adams
    The following report was prepared by Ann Whalen, celiac, and editor/publisher of Gluten-Free Living , which is a bimonthly newsletter for celiacs - Gluten-Free Living, PO Box 105, Hastings-on-Hudson, NY 10706.
    On March 10th, more than 20 members of the celiac community and celiac disease specialists (see list at end) attended a meeting of the Digestive Diseases Intra-agency Coordinating Committee, a part of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).
    The meeting, held to update the current status of Celiac Disease, was chaired by Jay Hoofnagle, M.D., Director of the Division of Digestive Diseases and Nutrition at the NIDDK. At the meeting, presentations were made by Martin Kagnoff, M.D., Joseph Murray, M.D., Alessio Fasano, M.D., and Frank Hamilton, M.D.
    Dr. Kagnoff is a gastroenterologist and Professor of Medicine at the University of California, San Diego. He spoke about his research into the genetics of Celiac Disease, focusing on the pathogenesis. Dr. Kagnoff is well known for his research into the genetics of Celiac Disease, and several of his studies have been funded by the NIH.
    Dr. Murray, Associate Professor of Medicine and clinician at the University of Iowa Hospitals and Clinics, described his experience with Celiac Disease both in Iowa and in Ireland, noting that his interest in celiac disease is clinical. He emphasized what he called the Classic II symptoms, meaning the actual symptoms patients have today and not the Classic symptoms many doctors may be familiar with. He said the rate of diagnosis is proportional to suspicion.
    Dr. Murray described the celiac disease experience at the University of Iowa from 1985 to 1997, presenting statistics that indicated a steep increase in diagnosis. At our institution, Celiac Disease is an adult disease, he said, and is now seen as frequently as Crohns Disease.
    Anticipating the question, Why look for Celiac Disease?, Dr. Murray gave his reasons: preventing lymphoma and osteoporosis, as well as resolving fatigue and nonspecific symptoms and shortening the current significant delays in diagnosis.
    Dr. Fasanos presentation was called Where Have All the American Celiacs Gone? He described what has happened in the field of celiac disease in various parts of the world, including some parts of the United States, but emphasized the European experience. Dr. Fasano noted that plans are already underway in Italy to screen all seven-year-olds in 1999.
    Dr. Fasano explained why an epidemiology study is critically needed in this country. He pointed out the benefits of such a study for four groups:
    The American health care community: lower health care costs, increased awareness of celiac disease and more knowledge of its protein manifestations in the US Participating physicians: publications, more patients and increased credibility. The American people: the prevalence will be established and celiac disease will be diagnosed more quickly. Celiac Patients: free screening of first-degree relatives, federal support for dietary and drug regulations, an improved food supply, stronger local support groups and more funding for celiac research. Dr. Fasano added that such a study, whatever its findings, would end in a win-win situation for everyone. If the study shows that celiac disease is underestimated in this country, patients will benefit as physicians begin looking for the problem with the knowledge that they might well find it. If the study shows celiac disease is indeed rare in the United States, its even more exciting because we will be able to figure out why.
    Dr. Hamilton, chief of the Digestive Diseases Program Branch at the NIDDK, briefly described the celiac disease research, to date, that has already been funded by the NIH. He said $1.4 million has been granted for such research, adding that over the last five years, we have seen growth in the funding of Celiac Disease. He said he was pleased funding has increased, and felt a lot of work has to be done.
    Dr. Hamilton ended by saying, Todays meeting will serve as an impetus for a partnership between the National Institutes of Health, academe, and the lay groups to foster more research. He added that it was important for the investigators and support group representatives present at the meeting to get the word out, referring to information about Celiac Disease.
    These talks were followed by a round table discussion, between the members of the committee and the presenters. Later, audience comment was invited. The committee showed an interest in the current adult nature of the disease, the changing symptoms, current testing methods, and identification of the most critical research needs. Patients who spoke were anxious to let the committee know what they felt were the important concerns in the real world.
    At the end of the meeting, Dr. Hoofnagle said his division will prepare a short, pithy plan, then present it to Drs. Kagnoff, Murray and Fasano. He noted that the important issues are pathogenesis, delivering the message to physicians, clinical research issues and pediatric health concern.
    Some Quotes from the Meeting
    Elaine Monarch: There is a general lack of knowledge, awareness and interest in Celiac Disease among the medical profession. We celiacs can go for years with substantial symptoms but not diagnosis...The cost to the medical community is enormous.
    Joseph Murray, M.D.: There is more than one gene involved in Celiac Disease. Most Europeans are homogenous. Here we have a mongrelized population. What happens when you mix? How much does it change? Our mongrelized population may be at risk at a later age.
    Martin Kagnoff, M.D.: The issue of other genes is not at all clear. Like Joe (Dr. Murray), I see adult celiacs. Their time delay to diagnosis is not exaggerated, but what is striking is the lack of knowledge of doctors, even at the University of California. They really are not aware of this disease.
    Alessio Fasano, M.D.: We receive 10-15 calls a day. The vast majority are self diagnosed. They say, I know more than my gastroenterologist.
    Peter Green, M.D.: We need to emphasize education of gastroenterologists. At my institution (Columbia-Presbyterian Medical Center in New York City), doctors are not used to looking at the duodenum...We need to educate many levels of the medical community and tell them, If you dont recognize something, take a biopsy.
    Sue Goldstein: Im concerned about the people who have not yet been diagnosed and the reasons why a physician wont consider Celiac Disease. It all boils down to, its rare and you cant have it.
    In addition to the speakers, the following were among those who attended:
    Phyllis Brogden, celiac, founder and chairperson of the Greater Philadelphia Celiac Sprue Support Group. Winnie Feldman, celiac, Celiac Disease Foundation Kenneth Fine, M.D., gastroenterologist/ researcher at Baylor University Medical Center in Dallas. Al Fornace, M.D., celiac, National Cancer Institute Sue Goldstein, celiac, founder and advisor, Westchester Celiac Sprue Support Group Peter Green, M.D., clinician/researcher at Columbia-Presbyterian Medical Center in New York City. Joanne Hameister, celiac, former chairperson, Western New York Gluten-Free Support Group Ivor Hill, M.D., clinician/researcher at Bowman Gray School of Medicine, Winston-Salem, North Carolina. Beth Hillson, celiac and proprietor of the Gluten-Free Pantry. Karoly Horvath, M.D., clinician/researcher at the University of Maryland School of Medicine in Baltimore. Marge Johanamen, celiac, CSA Kentucky state coordinator Pam King, University of Maryland Bob Levy, Celiac Research Foundation Ruth Levy, spouse Jax Lowell, celiac and author of Against the Grain Elaine Monarch, celiac, founder and Executive Director of the Celiac Disease Foundation Selwyn J. Monarch, Board of Directors, CDF Diane Paley, celiac, governing board CSA/USA Michelle Pietzak, M.D., pediatric gastroenterologist at Childrens Hospital, Los Angeles Connie Tur, celiac, president Greater Louisville Celiac Sprue Support Group


    Gryphon Myers
    Celiac.com 07/31/2012 - Dana Vollmer could be walking (or swimming) proof of the benefits a gluten-free diet can afford athletes. In the second day of London's 2012 Olympics, Vollmer, who suffers from gluten sensitivity and an egg allergy, took the gold medal in the Women's 100-meter butterfly final, breaking her own personal record, as well as the world record.
    What is interesting about Vollmer and her success is that she seems to have reached her athletic peak while on a gluten-free diet. In the days before her diagnosis, she did what many Olympic athletes do before competitions: load up on carbohydrates. With pasta and eggs out of the equation, that becomes harder to accomplish, so some might think that she would be at a disadvantage.
    Evidently, she is not missing the pasta or the eggs though. On Sunday, she managed to break the 6-minute mark, clocking in at 55.98 seconds to break the world record and set a milestone for athletes and celiacs everywhere.
    So what does Vollmer fuel her gold-winning machinery with? According to her Twitter feed, the hard-earned gold was won on rice, almonds, sunflower seeds, crushed peanuts, peanut butter, milk and bananas. In an interview with KidsHealth, she said she also eats a great deal of quinoa, lean meat, vegetables and brown rice.
    It may not be the carb-heavy diet that Olympic athletes have been trained on, but clearly Vollmer is getting the nutrition and protein she needs to take home medals. With this precedent set, perhaps more Olympic athletes will start adopting the gluten-free diet.
    Sources:
    http://www.nbcsandiego.com/news/health/Gluten-Free-Dana-Vollmer-164310186.html http://twitter.com/danavollmer http://kidshealth.org/kid/health_problems/allergiesimmune/vollmer.html


    Jefferson Adams
    Celiac.com 02/21/2014 - Doctors in India made a bit of a splash recently by using music to help raise awareness about celiac disease, which is rarely-discussed, and under-diagnosed in that country.
    The group, representing numerous areas of medical specialization, met to raise awareness about the disease, especially among their medical peers. Nearly 10 million (1 per cent of India's population) suffer from celiac disease, and very few cases are properly diagnosed.
    Organized by The Celiac Society of Delhi at India Habitat Centre, the event featured doctors speaking about celiac disease and the importance of making a correct diagnosis. To make sure their message got across, they included a musical performance.
    The diagnosis and management of celiac disease in India is, at present, poor, says Celiac Society founder and president Ishi Khosla, adding that "…cases are often mistaken for irritable bowel syndrome, Crohn's disease, tuberculosis or a form of auto-immune disorder."
    People with undiagnosed celiac disease have a much higher risk of getting life-threatening maladies later on in life.
    In addition to featuring music and talks, the conference also played host to guest of honor C.K. Mishra, additional secretary to the Union Ministry of Health and Family Welfare.
    Source:
    Express News Service: New Delhi, Sun Dec 15 2013


    Jefferson Adams
    Celiac.com 07/08/2014 - Gluten-free tennis superstar Novak Djokovic won his second Wimbledon title by outlasting the Swiss player, and seven-time champion, Roger Federer in five sets last Sunday.
    Up 5-2 in the fourth set, Djokovic was unable to capitalize at match point, but held on for a 6-7 (7), 6-4, 7-6 (4), 5-7, 6-4 victory at Centre Court.
    The championship returns the 27-year-old Serb to the world’s No. 1 ranking. Djokovic has seen his fortune improve since moving to a gluten-free diet, and credits his subsequent successes on court to his diet and to his mental conditioning.
    The rivalry between Djokovic and Federer has remained evenly balanced over the years. The two have faced each other 35 times, with Federer leading 18–17.
    They have faced off in a record 12 Grand Slam matches, including two finals, and a record nine semifinals.
    The win marked Djokovic's seventh Grand Slam title, ending a streak of three consecutive losses in major finals, and in five of his past six.
    Stay tuned for news on Djokovic’s progress, and on his gluten-free diet.


  • Popular Now

×
×
  • Create New...