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  • Scott Adams
    Scott Adams

    Positive Antigliadin Antibody (AGA) is a Poor Marker for Celiac Disease

    Reviewed and edited by a celiac disease expert.

    Eur J Gastroenterol Hepatol 2006;18:503-506.

    Celiac.com 08/14/2006 – A team of German researchers led by Dr. Martin W. Laass of the Childrens Hospital in Dresden have determined that antigliadin antibody (AGA) positivity disappears in over 50% of cases, and is therefore a poor marker for celiac disease. The researchers did follow up AGA testing on 69 adults and 47 children who participated in a much larger study conducted four years ago and found that only 26 of the adults and 21 of the children still had detectable levels of AGA in their blood samples, and none of them were positive for IgA-class anti-endomysial antibodies. Additionally no correlation was found in the subjects between their serum and fecal AGA.

    The researchers conclude that the appearance of AGA should be interpreted as a non-specific “immunomodulation phenomenon” that has low specificity as a diagnostic marker for celiac disease. The researchers emphasize that it is still unknown why the AGA markers are transient, but various conditions might account for it, including a change in the sensitivity of the test that was used in the original study conducted four years ago versus the one used in this study.


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  • About Me

    Celiac.com's Founder and CEO, Scott was diagnosed with celiac disease  in 1994, and, due to the nearly total lack of information available at that time, was forced to become an expert on the disease in order to recover. Scott launched the site that later became Celiac.com in 1995 "To help as many people as possible with celiac disease get diagnosed so they can begin to live happy, healthy gluten-free lives."  In 1998 he founded The Gluten-Free Mall which he sold in 2014. He is co-author of the book Cereal Killers, and founder and publisher of Journal of Gluten Sensitivity.

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