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  • Scott Adams
    Scott Adams

    Reaction to a Gluten Challenge

    Reviewed and edited by a celiac disease expert.

    The following post if from Karoly Horvath, M.D., khorvath@POL.NET, who is one of the two directors of the celiac center at University of Maryland in Baltimore.

    Q: Does that mean I could be getting damage without knowing it because I have no obvious reaction?

    A: Based on our studies a typical (biopsy proven flat mucosa, proved immune reactions to gluten) gluten intolerant patient does not react immediately with clinical symptoms for a gluten challenge (J Pediatr Gastroenterol Nutr 1989, 9:176-180). However, ingestion of GRAMS OF GLUTEN causes several changes in the intestine.

    • There is an accumulation of inflammatory cells
    • One cell type -so called mast cells- releases factors which factors in long-term damage the villi and they also release a factor which;
    • Increases the permeability -leakiness- of the intestine, which is a temporarily change after a single ingestion but may be permanent after repeat dietary mistakes.

    Karoly Horvath, M.D., Ph.D., Baltimore


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    Celiac.com's Founder and CEO, Scott was diagnosed with celiac disease  in 1994, and, due to the nearly total lack of information available at that time, was forced to become an expert on the disease in order to recover. Scott launched the site that later became Celiac.com in 1995 "To help as many people as possible with celiac disease get diagnosed so they can begin to live happy, healthy gluten-free lives."  In 1998 he founded The Gluten-Free Mall which he sold in 2014. He is co-author of the book Cereal Killers, and founder and publisher of Journal of Gluten Sensitivity.

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