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    Scott Adams
    Scott Adams

    Reversal of Psychopathology in Adult Coeliac Disease with the Aid of Pyridoxine (vitamin B6) - Scandinavia

    Reviewed and edited by a celiac disease expert.

    Source: Scandinavian Journal of Gastroenterology, 18:(2):299-304, 1983 Mar.
    Authors - Hallert C., Astrom J., Walan A.



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    Signs of mental depression are typical in adults with coeliac disease. The response to treatment was evaluated in 12 consecutive patients by means of the Minnesota Multiphasic Personality Inventory (MMPI), with surgical patients serving as controls. The coeliacs reported no change in depressive symptoms after 1 years gluten withdrawal despite evidence of improvement in the small intestine. When re-tested after 3 years, however, after 6 months of 80mg/day of oral pyridoxine (vitamin B6) therapy, they showed a fall in the score of scale 2 (depression) from 70 to 56 (p less than 0.01), which became normalized like other pretreatment abnormalities in the MMPI. Cholecycstectomy in the control subjects produced no alterations in the MMPI profile. The results indicate a causal relationship between adult coeliac disease and concomitant depressive symptoms which seems to implicate metabolic effects from pyridoxine deficiency influencing central mechanisms regulating mood.



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  • About Me

    Scott Adams

    Scott Adams was diagnosed with celiac disease in 1994, and, due to the nearly total lack of information available at that time, was forced to become an expert on the disease in order to recover. In 1995 he launched the site that later became Celiac.com to help as many people as possible with celiac disease get diagnosed so they can begin to live happy, healthy gluten-free lives.  He is co-author of the book Cereal Killers, and founder and publisher of the (formerly paper) newsletter Journal of Gluten Sensitivity. In 1998 he founded The Gluten-Free Mall which he sold in 2014. Celiac.com does not sell any products, and is 100% advertiser supported.


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  • Related Articles

    Scott Adams
    Celiac.com 11/24/2002 - The following is a Medline abstract on a study conducted by Italian researchers that demonstrated a connection between celiac disease and clinical depression.
    Scand J Gastroenterol 1998 Mar;33(3):247-50 Related Articles, Links
    Ciacci C, Iavarone A, Mazzacca G, De Rosa A.
    Dept. of Gastroenterology, University of Naples Federico II, Italy.
    BACKGROUND: Psychic symptoms and depression have been reported in celiac disease (celiac disease). The aim of this study was to explore depression in a large cohort of adult celiac disease patients.
    METHODS: Depressive symptoms were evaluated in 92 adult celiacs, 100 normal controls (NC), and 48 chronic persistent hepatitis (CPH) patients by means of a modified version of the Zung Self-Rating Depression Scale (M-SDS). celiac disease patients were evaluated for the level of knowledge about celiac disease and the compliance with diet.
    RESULTS: The M-SDS score differentiated celiac disease patients from NC. Age at diagnosis and duration of and compliance with diet did not correlate with depression. Three main factors could be identified with the M-SDS: reactiveness, pessimism, and anhedonic-asthenic.
    CONCLUSION: Depressive symptoms are a feature of celiac disease; they are present to a similar extent in patients with childhood- and adulthood-diagnosed celiac disease. The results underline the relevance of personal psychological resources, which play a fundamental role in determining and sustaining depression.


    Scott Adams
    Addolorato G; Stefanini gluten-free; Capristo E; Caputo F; Gasbarrini A; Gasbarrini G
    Institute of Internal Medicine, Universita Cattolica del Sacro Cuore, Rome.
    Hepatogastroenterology, 43(12):1513-7 1996 Nov-Dec
    Celiac.com 12/18/2002 - BACKGROUND/AIMS: Psychiatric illness and psychological behavioral pathologies may be present in celiac disease and in IBD patients. In these subjects anxiety and depression could be a main cause in the reduction of the compliance to the treatment. The aim of our study was to carry out a psychometric evaluation using appropriate means to determine the level of anxiety and depression and to distinguish between state and trait forms. The correction of such disturbances would improve the quality of life and the patients compliance to treatment.
    MATERIAL AND METHODS: Sixteen adult celiac patients, 16 subjects affected by IBD and 16 healthy control subjects matched for sex, residence and marital status were studied by psychological assessment. All the subjects were given the State and Trait Anxiety Inventory and the Ipat Depression Scale Questionnaire.
    RESULTS: State anxiety was present in a higher percentage of celiac subjects and in the patients affected by IBD with respect to the healthy controls. Anxiety as a trait was present in a similar percentage in all the subjects evaluated. Depressive syndrome was present in a percentage of celiac patients statistically superior versus the healthy control group (p
    CONCLUSION: Our results shown that anxiety is present as a reactive form and personality trait anxiety has no effect in celiac and IBD patients. With regard to depression, our data confirm a possible link between brain functions and malabsorption.


    Jefferson Adams
    Celiac.com 10/03/2011 - A number of studies show that people with celiac disease have higher risk of depression and death from external causes, but there are no conclusive studies on death from suicide.
    A research team set out to more deeply examine the risk of suicide in people with celiac disease. The team included J. F. Ludvigsson, C. Sellgren, B. Runeson, N. Långström, and P. Lichtenstein. They are affiliated with the Department of Paediatrics at Örebro University Hospital in Sweden.
    The team examined suicide risk in individuals with celiac disease where the small intestinal biopsy showed no villous atrophy.
    For their study, the team collected biopsy data from all 28 clinical pathology departments in Sweden for 29,083 individuals diagnosed during 1969-2007 with celiac disease with Marsh 3 villous atrophy, with inflammation without villous atrophy (Marsh 1-2; n=13,263), or with positive celiac disease serology, but normal mucosa (Marsh 0, n=3719).
    The team used Cox regression to calculated hazard ratios for suicide as recorded in the Swedish Cause of Death Register.
    The team found that people with celiac disease have a higher risk for suicide compared to general population control subjects (HR=1.55; 95%CI=1.15-2.10; based on 54 completed suicides).
    The results showed that suicide was more common among those who suffered from inflammation (HR=1.96; 95%CI=1.39-2.77), but the team found no such increase in people who showed positive celiac disease serology, but normal mucosa. (HR=1.06; 95%CI=0.37-3.02).
    Overall, the team found a slightly higher risk of suicide in patients with celiac disease than in the general population. The increased risk is one that merits attention from doctors, when treating patients with celiac disease.
    Source:
    Dig Liver Dis. 2011 Aug;43(8):616-22.


    Jefferson Adams
    Celiac.com 01/09/2012 - Women with celiac disease face a higher risk for depression than the general population, even once they have adopted a gluten-free diet, according to U.S. researchers.
    A team of researchers recently used a Web-mediated survey to assess a range of physical, behavioral and emotional experiences in 177 U.S. adult women, who reported a physician-provided diagnosis of celiac disease.
    The team was led by Josh Smyth, professor of biobehavioral health and medicine at Pennsylvania State University, and included members from  Syracuse University and Drexel University.
    The survey gathered information about how closely people follow a gluten-free diet and assessed various symptoms of celiac disease from physical symptoms to the respondents' experience and management of stressful situations, along with charting symptoms of clinical depression and frequency of thoughts and behaviors associated with eating and body image.
    Perhaps unsurprisingly, many women with celiac disease suffer from disordered eating, given that the management of celiac disease requires careful attention to diet and food, Smyth said.
    "What we don't know is what leads to what and under what circumstances," Smyth said. "It's likely that the disease, stress, weight, shape and eating issues, and depression are interconnected."
    The findings are forthcoming in the journal of Chronic Illness.
    Source:
    http://www.upi.com/Health_News/2011/12/28/Celiac-ups-depression-risk-for-women/UPI-75401325131984/#ixzz1iQynze9k.


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