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  • Jefferson Adams
    Jefferson Adams

    Specific Gene Tied to Dermatitis Herpetiformis

    Reviewed and edited by a celiac disease expert.

    Celiac.com 01/08/2008 - Scientists at the University of Finland have announced the discovery of a particular gene that is tied to the development of the celiac-associated skin disease dermatitis herpetiformis, which is the form of celiac disease found in a full 25% of all celiacs. The gene is called myosin IXB, and it is located on chromosome 19p13.

    In addition to being connected with a higher risk of celiac disease in both Dutch and Spanish populations, the gene has been associated with a higher risk of inflammatory bowel disease, systemic lupus, erythmatosus, and rheumatoid arthritis, which means that myosin IXB is likely a shared risk factor in all of these disorders.

    Researchers looked at nearly 500 Hungarian and Finnish families, plus another 270 patients and controls. What they found was a substantial linkage to chromosome 19p13 (LOD 3.76 P=0.00002) that lends great weight to the notion that this is a substantial risk factor. Other variants of the myosin IXB gene showed no connection with celiac disease, though they did show a small connection to dermatitis herpetiformis.

    Both phenotypes show a significant connection indicating that the role meaning that there still may be a role being played by nearby genes. They are calling for more comprehensive genetic and functional studies to determine what the exact nature of the role the myosin IXB gene in both celiac disease and in dermatitis herpetiformis.

    As more studies are conducted, and more data emerges, we are likely to get a much clearer genetic picture of both celiac disease and dermatitis herpetiformis. A clearer genetic picture will likely lead to new and novel approaches to treatment that permit much more effective targeting of treatment.

    Journal of Med. Genet. 2007 Dec 12


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    My husband found out he had celiac 13 years ago. He developed an itchy rash on his eye lids very itchy and burning. We went to 3 different doctors in N.Y. no one could help him. I found a web site about dermatitis herpetaformis and got him off iodized salt. Within days it went away. That was 6 years ago. It came back a couple of months ago. We only used un- iodized salt in my house. Does any one have any suggestions. I have yet to hear if anyone else suffers from DH on their eyelids.

    I HAVE ITCHY EYELIDS BUT NO RASH. I DID NOT THINK IT WAS RELATED TO MY DERMATITIS HERPETIFORMIS. I HAVE SCALP PROBLEMS FROM DH. I ALSO HAVE celiac disease. AFTER A YEAR ON THE gluten-free DIET, I AM STILL NOT FEELING BETTER. THE MORE TESTS THAT ARE DONE, MORE PROBLEMS ARE DISCOVERED. i AM LOOKING FORWARD TO THE DAY I FEEL BETTER.

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    I HAVE ITCHY EYELIDS BUT NO RASH. I DID NOT THINK IT WAS RELATED TO MY DERMATITIS HERPETIFORMIS. I HAVE SCALP PROBLEMS FROM DH. I ALSO HAVE celiac disease. AFTER A YEAR ON THE gluten-free DIET, I AM STILL NOT FEELING BETTER. THE MORE TESTS THAT ARE DONE, MORE PROBLEMS ARE DISCOVERED. i AM LOOKING FORWARD TO THE DAY I FEEL BETTER.

    I can really relate. I suffer from scalp, facial, chest and back lesions. I've been gluten-free for over a year now and I've seen very little progress. I also never ever cheat. I don't eat out, refuse to take any pills besides dapsone and have basically become a hermit. I only leave the house when I have to go to work. Thankfully, I work in a cube that is far away from the public. I resumed Dapsone at a low level because I cannot take these facial lesions anymore . I have had low blood counts on this medication before but I do not see any alternative. I've used Flucocinide (steriods) on my scalp for over a year and they are still not "disappearing". There are days that I just want to die. I do not relish the thought of living 40 plus more years with this disease.

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    I too suffer with severe acute "eczema". I am convinced after much research that I have DH. being 100% gluten free for 6 months has not helped. some days I feel like I am going to lose my mind.

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    I have had DH and celiac disease for over 50 years, and have found that there are over 300 different DX that things that can show up as celiac disease or DH. It took 9yrs before I new I had DH and 40 more to find about celiac disease. I would not wish this on anyone.

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    Does beer, wine and spirits affect DH? Anyone with this experience like to hear from them.

    You can have DH/Celiac reactions to any alcoholic drink that is made from wheat, rye or barley. I have not had a problem with Jack Daniels or other purely corn mash derived whiskey. Budweiser now makes Red Bridge, a gluten free beer that is excellent with a nice full flavor. I have never had a problem from any wines except those that contain tannins from oak. Tannins can cause extreme swelling of the esophagus.

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    Six months gluten free and this just showed up. I thought I had dust mites or spider bites, and now I have Dermatitis Herpetiformis. Home remedies? HELP! I don't have health care...

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    Six months gluten free and this just showed up. I thought I had dust mites or spider bites, and now I have Dermatitis Herpetiformis. Home remedies? HELP! I don't have health care...

    I found this after Googling dermatitis herpetiformis and eyes. I am 33. My dermatitis herpetiformis broke out in college when I started drinking tons of beer. I can sympathize with everyone on this blog. My dermatologist diagnosed me after about five office visits. His diligence saved my life. Dapsone and diet help tons, but relapse is horrible.

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    I have to completely avoid wheat, rye, barley and oatmeal or I itch badly. I take vitamin C pills (ester c) 2 to 6 per day which really helps stop the itch. You must stay gluten-free diet. I also am allergic to dairy.

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    I wonder if celiac could have caused a condition which I had, years ago, Hydatidiform molar pregnancy. This resulted in a hysterectomy at age 24. Now, granted, this was back in 1963...and, yes, I have been confirmed as having celiac.

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  • About Me

    Jefferson Adams is Celiac.com's senior writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University, and has authored more than 2,000 articles on celiac disease. His coursework includes studies in biology, anatomy, medicine, science, and advanced research, and scientific methods. He previously served as SF Health News Examiner for Examiner.com, and devised health and medical content for Sharecare.com. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of the book "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.

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