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  • "Vaccine" for Celiac Disease

    Reviewed and edited by a celiac disease expert.

      The "vaccine" Nexvax 2 is designed to work similar to allergy shots.


    Caption: Image: CC--Steven Depolo

    An experimental "vaccine" called Nexvax 2 is being scheduled for human clinical trials to evaluate its effectiveness in celiac disease. Immusan T is a biotechnology company focusing on developing therapeutic vaccines and received $40 million in 2017 to fund Nexvax 2 to reduce the "suffering of those with celiac disease since it is a serious inflammatory autoimmune disease caused from gluten".

    Since there is no cure for celiac disease except following a strict gluten-free diet, symptoms can vary greatly based on age and diet content. Children with DQ2 and DQ8 genes may have a swollen belly, chronic diarrhea and poor appetite which can cause delayed growth. Adults often experience abdominal pain, fatigue, anemia and joint pain. 

    When grain products- containing gluten and gliadin- are consumed tissue transglutaminase in the small intestinal lining signals an immune response that produces antibodies which attack the lining of the small intestine. This leads to malabsorption of nutrients from food. Nutrient deficiencies cause liver, bone and neuron damage resulting in abnormal growth, poor tissue repair and numerous symptoms.

    Allergy vs Auto-Immune Disease

    It is important to understand that celiac disease and dermatitis herpetiformis (itchy, blistery skin rash) are auto-immune disorders NOT an allergy to gluten. Allergies occur when the immune system overreacts to a compound causing the release of histamines. An auto-immune disorder results when the body misidentifies a substance as dangerous and causes the immune system to attack the body's own tissue.

    Celiac Disease Epidemic

    Celiac disease and gluten enteropathies are a growing epidemic in the U.S. and across the world due to the increasing use of processed foods and food additives that use grain products for thickening, stability and dietary supplement fillers. Environmental factors may contribute to a person becoming gluten intolerant even after decades of consuming gluten without suffering serious health consequences.

    How "Vaccine" Works

    The "vaccine" Nexvax 2 is designed to work similar to allergy shots according to Live Science (Nov. 9, 2018). The treatment involves twice weekly injections administered over a 16 week (4 months) period to reprogram T cells to begin to tolerate gluten and suppress immune destruction of the villi in the small intestine. No available data is currently available on the ingredients used in Nexvax 2 so safety can not be assessed at this point.

    What is known is that vaccines DO NOT mean immunization whether through injection or oral dosing. Immunization is a process for developing tolerance and protection against infections. Dorland's Medical Dictionary states vaccination means to "inject a suspension of attenuated or killed microorganisms administered for prevention or treatment of infectious disease".

    The Center for Disease and Prevention Control (CDC) states that vaccination does NOT guarantee immunity. Natural immunity comes only after a person recovers from the actual disease, and not all who receive a vaccination will have immunity. No vaccine is 100% effective because everyone's immune system reacts differently.

    Before lining up to participate in the clinical trials, adapt a more educated approach to vaccination safety regarding a disease managed very effectively by a healthy gluten-free, lectin-free diet. It is a personal decision for adults with celiac disease whether or not they chose to vaccinate. 

    It will be many years before the safety of this celiac disease "vaccine" can be established.  On a personal note: I have been a celiac for more than 70 years and would never consider a "vaccine" just so I didn't have to worry about hidden gluten. 


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    On 1/21/2019 at 10:05 PM, Guest SDPrairieCeone said:

    Guest Daisy - You are unnecessarily restricting yourself. There are tons of gluten-free flour mixes, cake mixes, pasta, and pizzas on the market. Yes, they are spendy, but many makers offer coupons online. Many recipes I use for quick breads and cakes adapt very well to substituting gluten-free flour blend for all-purpose flour. Experimentation with your own favorites is needed. Best hint ever to counteract the dryness/crumbles of baked goods from a chef I know who has experience with gluten-free food prep: add a big blob of sour cream. Made the best ever cobbler topping! You are limited only by your imagination. I have gifted cakes and cookies to friends and neighbors and they are always shocked when I tell them "It's gluten free." You don't have to wait for a medical treatment to enjoy your life now. I control my Celiac, it does not control me.

    That’s all great but it’s the feeling/nervousness  when you go to a wedding, birthday party, or a holiday at someone’s house. There’s a lot of stress that goes along with celiac disease. 

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    On 1/22/2019 at 9:56 AM, Guest Michelle Morgan said:

    Well they have gluten free pastas bread , chips cakes 🎂 and etc. found in wal mart mainly I’ve found it in Kroger .. also I’ve found out gluten free food higher in calories and sodium.. 

    There are plenty of gluten free breads, cookies, cake mixes etc...but at least  double the price of regular food.  

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    Guest mom of son that hurts

    Posted

    You may never consider a vaccine but from someone that has a son so sensitive that he can't walk due to joint pain several times a week, a vaccine would be wonderful.  He can be in a room with people that aren't even eating food but have it on their hands etc.  He shakes no ones hand, he eats no food he doesn't prepare, he tries not to touch surfaces and still has terrible issues.  A vaccine would be awesome so he could have his life back.  I am glad yours isn't so bad that you would want one but don't discount those that need it.

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    34 minutes ago, Guest mom of son that hurts said:

    You may never consider a vaccine but from someone that has a son so sensitive that he can't walk due to joint pain several times a week, a vaccine would be wonderful.  He can be in a room with people that aren't even eating food but have it on their hands etc.  He shakes no ones hand, he eats no food he doesn't prepare, he tries not to touch surfaces and still has terrible issues.  A vaccine would be awesome so he could have his life back.  I am glad yours isn't so bad that you would want one but don't discount those that need it.

    Hi, He may have additional food intolerances that have developed and are causing symptoms.  Nightshades and soy are 2 that seem to be associated with joint pain.  Also vitamin D deficiency can cause it.

    Edited by GFinDC

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    38 minutes ago, Guest mom of son that hurts said:

    You may never consider a vaccine but from someone that has a son so sensitive that he can't walk due to joint pain several times a week, a vaccine would be wonderful.  He can be in a room with people that aren't even eating food but have it on their hands etc.  He shakes no ones hand, he eats no food he doesn't prepare, he tries not to touch surfaces and still has terrible issues.  A vaccine would be awesome so he could have his life back.  I am glad yours isn't so bad that you would want one but don't discount those that need it.

    I'm 10000% for the vaccine, If it can make me feel physically better, mentally better  and not feel like everytime I tell someone I can't have gluten because I have celiac, the contstant reaction i get from people is "Oh stop how is some crumbs or cross contamination going to effect you" or I get especially when Im out "is this a diet?  NO ITS NOT A DIET! im so tired of people downplaying this celiac, gluten sensitivity thing.  Yes its real. The pain, bloating, headaches, nervousness when im out or home to make sure there's no cross contamination in my own house.  It's a daily struggle. 

     

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  • About Me

    Betty Wedman-St Louis, PhD, RD is Assistant Professor, NY Chiropractic College, MS Clinical Nutrition Program Nutrition Assessment Course & Food Science Course.  She is author of the following books:

    • Fast and Simple Diabetes Menus, McGraw Hill Companies
    • Diabetes Meals on the Run, Contemporary Books
    • Living With Food Allergies, Contemporary Books
    • Diabetic Desserts, Contemporary Books
    • Quick & Easy Diabetes Menus Cookbook, Contemporary Books
    • American Diabetes Association Holiday Cookbook and Parties & Special Celebrations Cookbook, Prentice Hall Books

     

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