Jump to content
  • Sign Up
Celiac.com Sponsor:


Celiac.com Sponsor:


  • Join Our Community!

    Get help in our celiac / gluten-free forum.

  • Jefferson Adams

    What's a Minigut, and How is it Helping to Solve Celiac Disease Mysteries?

    Jefferson Adams


    Reviewed and edited by a celiac disease expert.

      Miniguts are 3D models that allow researchers to mimic gut cell function in people with celiac disease. They may help researchers unlock celiac disease mysteries.


    Caption: Image: CC BY 2.0--U.S. Army RDECOM Chemical & Biological Center

    Celiac.com 07/09/2019 - Behold the minigut. What, you might ask, is a minigut? Developed by researchers at Massachusetts General Hospital, miniguts are exactly what they sound like: simplified versions of the human intestine (about one millimeter in size) that give researchers a powerful new tool for studying celiac disease.

    Miniguts are 3D models that allow researchers to mimic gut cell function in people with celiac disease. In a recent study, a research team from the Mucosal Immunology and Biology Research Center led by Stefania Senger, PhD, showed that these minigut models mirror the molecular and functional changes that happen in intestinal cells of celiac patients who are exposed to gluten.



    Celiac.com Sponsor:




    People with celiac disease have to eat a lifelong gluten-free diet. And scientists still know precious little about how celiac disease develops, and how it works in the gut.

    New Model for Understanding Celiac Disease

    The miniguts provide researchers with an easy, reliable way to model celiac disease in the lab. Unlike many other diseases, researchers currently lack an animal model that can mimic the progression of celiac disease in humans.

    As part of their study, the team showed that the epithelial cells lining the intestine play an active role in celiac disease. The team also found evidence that the microbiome may influence certain cell functions which in turn influence the severity of the disease.

    Epithelial Cells and Celiac Disease

    Researchers know that people with celiac disease suffer damage to their epithelial cells when gluten triggers an immune response. Until now, though, it was not clear if epithelial cells played an active role in the development of celiac disease.

    Gut Microbiota May Influence Celiac Disease Severity

    This is one of the first studies to show that human gut microbiota "can influence communication between epithelial and immune cells and might be crucial to promoting gluten tolerance,” says Senger. Clearly more information is needed, but the role of gut microbiota in celiac disease development looks to be a promising area of inquiry for researchers looking to unlock the secrets of celiac disease development.

    Read more in the Mass General Research Institute Blog


    User Feedback

    Recommended Comments

    There are no comments to display.



    Join the conversation

    You are posting as a guest. If you have an account, sign in now to post with your account.
    Note: Your post will require moderator approval before it will be visible.

    Guest
    Add a comment...

    ×   Pasted as rich text.   Paste as plain text instead

      Only 75 emoji are allowed.

    ×   Your link has been automatically embedded.   Display as a link instead

    ×   Your previous content has been restored.   Clear editor

    ×   You cannot paste images directly. Upload or insert images from URL.


  • About Me

    Jefferson Adams is Celiac.com's senior writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University, and has authored more than 2,500 articles on celiac disease. His coursework includes studies in science, scientific methodology, biology, anatomy, medicine, logic, and advanced research. He previously served as SF Health News Examiner for Examiner.com, and devised health and medical content for Sharecare.com. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of the book "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.

  • Related Articles

    Jefferson Adams
    For the first time, researchers at the University of Chicago Celiac Disease Center will use mouse model research to explore root causes of celiac disease, test new therapies, and explore new targets for treatment.
    Celiac disease is the most common genetic autoimmune disease in the world. Celiac disease affects approximately three million Americans, but only three out of every...

    Jefferson Adams
    Celiac.com 10/17/2016 - Refractory celiac disease is a severe condition with few good treatment options, and which often eventually results in death. A group of researchers recently set out to create a prognostic model to estimate survival of patients with refractory celiac disease.
    The research team included A. Rubio-Tapia, G. Malamut, W. H. M. Verbeek, R. L. J. van Wanrooij...

    Michelle Melin-Rogovin
    Celiac.com 11/23/2018 - The complex factors that lead to the development of celiac disease in a given individual are the subject of much research.  The immune system, genetics and the environment (meaning factors in an individual’s life that would influence the development of disease) all play an important part in this process.
    Current research on celiac disease focuses on...

  • Celiac.com Sponsor:

  • Forum Discussions

    Never went to a "gym" always felt on edge there and only used hotel ones at 4am when no one else was. What  invested in a few years after I got diagnosed was a set of resistant bands, a stationary bike (late got a under desk elliptical,...
    Think I just had a serve response to some red wine I drank last night, severe cramps, bloating, etc. I have never had a reaction like this to red wine, a new bottle I’ve never tried before. Has anyone had a gluten reaction to red wine? ...
    It's not because it's a new year. It's because I want to do something new now that my life has changed due to Celiac disease.  I'm eating way less junk nowadays and I miss it a lot. Never been a health interested person before, but I ...
×
×
  • Create New...