Celiac.com Sponsor (A1):

Celiac.com Sponsor (A1):

  • Join Our Community!

    Get help in our celiac / gluten-free forum.

  • Jefferson Adams

    What's the Role of IL-24 in Celiac Disease?

    Jefferson Adams
    1 1
    Reviewed and edited by a celiac disease expert.   eNewsletter: Get our eNewsletter

      New findings suggest a major role for IL-24 in the maintenance of duodenal mucosal integrity in celiac disease.

    Caption: DARPin in Complex with IL-4 (two models, snap together) PDB 4YDY. Image: CC0 1.0--Marco Rdkc

    Celiac.com 02/15/2020 - Recently, involvement of interleukins IL-19, IL-20 and IL-24 has been reported in inflammatory diseases associated with tissue remodeling. However, researchers know very little about the exact way in which they influence the development and mechanics of celiac disease.

    To get a better understanding of the situation, a team of researchers recently set out to find out more about the role of IL-19, IL-20 and IL-24 in inflammatory diseases associated with tissue remodeling. 

    Celiac.com Sponsor (A12):

    The research team included Réka Rokonay,1 Apor Veres-Székely,1 Beáta Szebeni,2 Domonkos Pap,2 Rita Lippai,1 Nóra J. Béres,1 Gábor Veres,3 Attila J. Szabó,1,2 and Ádám Vannay. They are variously affiliated with the 1st Department of Paediatrics, Semmelweis University, 54 Bókay Street, Budapest, 1083 Hungary; the MTA-SE Paediatrics and Nephrology Research Group, Hungarian Academy of Sciences and Semmelweis University, Budapest, Hungary; and the Pediatric Institute-Clinic, University of Debrecen, Debrecen, Hungary.

    The team measured expression of IL19, IL20 and IL24 using real-time RT-PCR, protein amount of IL-24, and assessed α smooth muscle actin (α-SMA) and fibronectin (FN) using Western-blot analysis in the duodenal biopsies of untreated children with celiac disease and a group of control subjects.

    They used immunofluorescent staining in the duodenal mucosa to assess localization of IL-24 and IL-20RB. The team assessed the effect of recombinant IL-1β, TNF-α, TGF-β and IL-17 treatment on the expression of IL19, IL20, IL24 and their receptors by real-time RT-PCR in small intestinal epithelial cells (FHs74Int), in primary duodenal myofibroblasts (pdMFs) and in peripheral blood mononuclear cells (PBMCs). 

    To gauge the effect of IL-24 on H2O2 treated FHs74Int cells and on pdMFs, the used MTT, LDH, Annexin V assays, real-time RT-PCR and fluorescent microscopy. The team's findings suggest that IL-24 plays a major role in the maintenance of duodenal mucosal integrity in celiac disease. More research is needed to more fully understand the role of IL-24 in celiac and other diseases.

    Find more, including detailed results, at the Journal of Transl Med. 2020; 18: 36

    1 1

    User Feedback

    Recommended Comments

    There are no comments to display.

    Join the conversation

    You are posting as a guest. If you have an account, sign in now to post with your account.
    Note: Your post will require moderator approval before it will be visible.

    Add a comment...

    ×   Pasted as rich text.   Paste as plain text instead

      Only 75 emoji are allowed.

    ×   Your link has been automatically embedded.   Display as a link instead

    ×   Your previous content has been restored.   Clear editor

    ×   You cannot paste images directly. Upload or insert images from URL.

  • About Me

    Jefferson Adams is Celiac.com's senior writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University, and has authored more than 2,500 articles on celiac disease. His coursework includes studies in science, scientific methodology, biology, anatomy, medicine, logic, and advanced research. He previously served as SF Health News Examiner for Examiner.com, and devised health and medical content for Sharecare.com. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of the book "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.

  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):

    Celiac.com Sponsors (A17):

  • Related Articles

    Jefferson Adams
    Celiac.com 09/16/2008 - Cytokines are regulatory proteins that act as mediators in the generation of an immune response. Interleukin 21 (IL-21) is on such cytokine.
    A team of Italian and British researchers recently evaluated the production of IL-21 in the intestinal mucosa of patients with untreated celiac disease. Several studies have documented the ability of IL-21's to...

    Jefferson Adams
    Celiac.com 08/06/2009 - A study by a team of Spanish researchers puts the world on notice that gluten may trigger adverse reactions in both celiacs and non-celiacs alike. The research team was made up of E. Arranz, D. Bernardo, L. Fernandez-Salazar, J. A. Garrote and their colleague S. Riestra, all doctors based in Spain.
    According to the current medical wisdom, innate immunity...

    Jefferson Adams
    Celiac.com 03/18/2011 - By blocking an inflammatory protein called interleukin-15 (IL-15), doctors may be able to treat and prevent symptoms of celiac disease in some people, according to a new study in the journal Nature.
    The data suggest that the inflammatory response to gluten in people with celiac disease may be triggered by interleukin-15 and retinoic acid, which is a derivative...

    Jefferson Adams
    Celiac.com 12/04/2019 - There still is no easy and accurate way to monitor and diagnose celiac disease in patients who've been on a gluten-free diet for a while. Celiac disease patients on a gluten-free diet experience reactions to gluten, but researchers really don't understanding those reactions in any meaningful way. Systemic cytokine release was recently linked to reactivation...