Jump to content
This site uses cookies. Continued use is acceptance of our Terms of Use and Privacy Policy. More Info... ×
  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.




  • Celiac.com Sponsor (A1):



    Celiac.com Sponsor (A1-M):


  • Get Celiac.com Updates:
    Support Celiac.com!
    eNewsletter
    Donate
  • Record is Archived

    This article is now archived and is closed to further replies.

    Jefferson Adams
    Jefferson Adams

    Why All the Hate for Celiac Disease Drug Treatments?

    Reviewed and edited by a celiac disease expert.
    Why All the Hate for Celiac Disease Drug Treatments? - Big pharma, and celiac drug treatments get a red light from many readers. Photo: CC--Kenny Louie
    Caption: Big pharma, and celiac drug treatments get a red light from many readers. Photo: CC--Kenny Louie

    Celiac.com 09/18/2015 - That old saw about death and taxes might need a bit of amending to include complaints about pharmaceutical companies working on celiac drug treatments.

    One interesting facet of our coverage of the development of various drugs to treat and/or cure celiac disease has been the regular presence of comments questioning the motives,and actions of the companies involved.

    Celiac.com Sponsor (A12):
    It's funny, but no one complains that companies still make money selling aspirin, and that no one has cured a headache, and that there must be some conspiracy to profit off of those who suffer a headache.

    There's no doubt that there's money to be made producing drugs that treat disease. But, if a company can develop and produce a safe drug to protect celiacs against contamination, or to help reduce symptoms, what's wrong with that?

    Just like an aspirin, I can take it or not take it.

    In the old days, ten years ago or more, people with celiac disease generally suffered in silence, with scant gluten-free food choices, and little information. However, in just a decade, we've got a wealth of information, and multi-billion dollar gluten-free foods market and a number of companies developing drugs to treat or cure celiac disease.

    To me, that's a good thing. Still, there are naysayers. Here's a rundown of comments by readers who seem less than enthused about celiac drugs in development.

    Our recent article, An Update on Every Celiac Disease Drug Currently in Development included the comment:

    "Article's fine. Concept's disturbing. Eating a gluten-free diet is the free, already-proven cure for celiac and gluten-intolerance. They don't have to torture mice and likely other animals to find a 'cure' for something that there already is a cure for. I imagine there is $$ for the researchers here and $$ for the animal labs and $$ for the pharmaceuticals."

    Of our article entitled, How Close Are New Celiac Disease Treatments? one reader wrote:

    • "I would be very cautious about taking any of these until it was proven absolutely to have no side effects. There always are some and history has shown some to be deadly."

    Commenting on our article ALV003 Reduces Gluten Damage in Celiac Disease Patients, one reader commented:

    "I only want to know: how long until random internal organs begin to fail or malfunction as a result of yet another new mystery drug? I'd rather starve to death than be a guinea pig for big pharma again."

    Our article on NexVaxx, entitled Is a Vaccine for Celiac Disease Just Around the Corner? included the following comments:

    • "Totally agree with vhill seems like a ploy to poison people with GMO foods that come up with a supposed "'cure'. Eat healthy whole foods this is not a curse its a wake up call to be healthy if you didn't have celiac you'd probably be eating processed crap."
    • Balm wrote: "Thanks but no thanks. I'll remain a celiac and continue to eat healthy. While trying to fix one problem, some will end up with far worse problems."
    • Jonnys wrote: "Stupid idea! Just another way to make more money off of people."

    These are but a few of the largely positive comments we receive, and we hope you enjoyed them as much as we do.



    User Feedback

    Recommended Comments



    Guest Linda

    My son is one of the "super sensitives" He cannot tolerate even the smallest amount of gluten without getting sick. He follows a very strict gluten free diet and is OK with that. Its the accidental glutening that makes life difficult for him. Unless a restaurant is 100% dedicated gluten free, he won't dine out. (there are not in the city where he lives) He pretty much cooks and prepares everything he eats. But he travels a good amount for work and this is always a problem. He is not looking to take a pill and be able to eat wheat products. All he wants is to be able to go out and maybe once in a while, order off a gluten free menu and not have to worry about cross contamination. If there is a medication that can do that for him, that would be wonderful.

    Link to comment
    Share on other sites
    Guest Peggy

    Someone else hit the nail on the head exactly. I'm not sick. I don't need a cure. Eating gluten free is a way of life, not something that needs to be fixed. Who wants to "fix" me and why? I strongly suspect they don't want to "fix" me for my own good but for the good of food companies and restaurants who will have justification to stop worry about cross contamination. Why would I risk my body by taking unnatural drugs cooked up a lab? Every so called wonder cure out there has terrible side effects. Why would I risk that when I don't have to?

    Link to comment
    Share on other sites
    Guest Rebecca

    I think some of the strong opinions are due to the distrust of Big Pharm as there are some very dangerous drugs on the market with many unknown side effects, but for me what I love about the Gluten Free "movement" (for lack of a better word) is that it has demanded healthy change in our foods and even more awareness to get back to whole foods. I for one have learned so much from this journey I am on for my daughter about the food we eat. I guess I have some fear that if there was a pill available the doctor would have just put my daughter on it like they have done for her Hashimoto's and we would not have been forced to try a GFD. Being able to treat her celiac thru diet has been empowering, I am grateful she doesn't need to take a drug. That being said I am grateful for all research in the autoimmune area and also look forward to the day that she can have a relatively safe drug available, if needed, when traveling or at a big event when it is not easy to control what she eats.

    Link to comment
    Share on other sites
    Guest Bob Smith

    Posted

    People in general are stupid and naive. They believe crap they read on Facebook and then they spout off like they know what they are talking about.

    Bring on the cure. I'm HAPPY to pay for it. I hate being a celiac and hate having to eat gluten free. I love pizza and I love beer and no not that gluten-free crap. I hate that every time we go out to eat several of us "can't just order"...I really hate it all. I want to eat what I want to eat and not what I have to eat. So please bring on a cure.. if you don't want to take meds or vaccines or whatever they have then fine...let others get it if they want it.

    Link to comment
    Share on other sites
    Guest PamLevy

    Who in the world would complain about a medicine for this disease? I hate HAVING to be gluten-free and I NEVER Cheat. I don't think the gluten-free foods are nearly as tasty, satisfying and it has really hampered my lifestyle. I will jump for joy the day a med is offered to me!!!! Are you kidding me? I am looking for a study I can be in to try a med.

    Link to comment
    Share on other sites
    Guest PamLevy
    People in general are stupid and naive. They believe crap they read on Facebook and then they spout off like they know what they are talking about.

    Bring on the cure. I'm HAPPY to pay for it. I hate being a celiac and hate having to eat gluten free. I love pizza and I love beer and no not that gluten-free crap. I hate that every time we go out to eat several of us "can't just order"...I really hate it all. I want to eat what I want to eat and not what I have to eat. So please bring on a cure.. if you don't want to take meds or vaccines or whatever they have then fine...let others get it if they want it.

    I couldn't agree more. I HATE being gluten-free. I dream about real Pizza, Pasta and cinnamon rolls. ARE YOU KIDDING ME???

    Link to comment
    Share on other sites
    Guest PamLevy
    Why accuse Pharma companies of just trying to make money off celiacs? Yes, a gluten free diet is healthier by far, but look at the prices we have to pay for gluten free products. Why are the prices so high when the ingredients are rice flour and tapioca starch, both very inexpensive!!! Whose trying to make money and gouge people???

    NO JOKE so expensive. I pray daily for meds for this disease, I HATE having to be gluten-free. Your diet controls your entire life.

    Link to comment
    Share on other sites
    Guest Kelvin S.

    Posted

    Why accuse Pharma companies of just trying to make money off celiacs? Yes, a gluten free diet is healthier by far, but look at the prices we have to pay for gluten free products. Why are the prices so high when the ingredients are rice flour and tapioca starch, both very inexpensive!!! Whose trying to make money and gouge people???

    Food can be inexpensive when it can be mass-produced. Ensuring no cross-contamination, creating new recipes that look and taste good while using unusual ingredients, shipping small quantities, and other specialty issues all raise prices. (Some of the gluten-free items we buy come from Australia; quinoa typically comes from the backcountry Andes...) We have a free-market system; if products are being sold at prices that provide excessive profits, there's nothing to prevent another producer from stepping in and selling at better prices. But don't forget that Americans overall spend much less for food than people almost anywhere else in the world, so part of the issue is simply the difference between world-typical prices and the discounts offered by high volume food processing. (Whether the latter is healthy for anyone, celiac or not, is a separate issue.)

    Link to comment
    Share on other sites
    Charli61

    I bought a bottle of Gliadin X a few months ago.  I do not know that it is wonderful or is not wonderful, what I do know is that if I have to eat out, I take one.  Even if I am assured that it is G.F.   And, I have not been C.C.ed since doing that.  I don't eat out a lot, but when I do... I protect myself.  Maybe I would have been fine, but in my prior experience probably not.  So, Gliadin X, you do seem to work!!  ;)

    Link to comment
    Share on other sites
    Guest Erik

    Posted

    I am happy to see the interest in developing a cure. As one of the few who have been diagnosed with Type 2 Refractory Celiac Disease, the Gluten free diet does not work. Historically, after diagnosis, there is a 40 to 57% chance of living 5 years with a 50/50 chance of developing EATL. It would be nice to turn off the Celiac gene(s) or to fool the autoimmune system into not attacking its self for no reason. 

    Link to comment
    Share on other sites



    Guest
    This is now closed for further comments

  • Get Celiac.com Updates:
    Support Celiac.com:
    Donate
  • About Me

    Jefferson Adams

    Jefferson Adams is Celiac.com's senior writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University. His articles, essays, poems, stories and book reviews have appeared in numerous magazines, journals, and websites, including North American Project, Antioch Review, Caliban, Mississippi Review, Slate, and more. He is the author of more than 2,500 articles on celiac disease. His university coursework includes studies in science, scientific methodology, biology, anatomy, physiology, medicine, logic, and advanced research. He previously devised health and medical content for Colgate, Dove, Pfizer, Sharecare, Walgreens, and more. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of numerous books, including "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.

    >VIEW ALL ARTICLES BY JEFFERSON ADAMS

     


  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):





    Celiac.com Sponsors (A17-M):




  • Related Articles

    Jefferson Adams
    Celiac.com 09/10/2007 - A study published recently in the journal of Alimentary Pharmacology and Therapeutics shows that the paracellular permeability inhibitor AT-1001 effectively reduces intestinal barrier dysfunction, proinflammatory cytokine production, and gastrointestinal symptoms in people who have celiac disease. At present, a lifetime devoted to following a strict gluten-free diet is the backbone of current treatment for celiac disease. However, as researchers have come to know more about celiac disease, they’re insights are leading to developments that offer more effective prognosis and treatment of the disease.
    One of those promising new approaches involves treating celiac patients with doses of AT-1001, a paracellular permeability inhibitor that is structurally d...


    Jefferson Adams
    Celiac.com 03/30/2012 - A company called Microtest Laboratories is manufacturing doses of what they claim may be the first effective vaccine treatment for celiac disease. At this point, the only treatment for celiac disease is to avoid gluten in the diet.
    Other companies are working on vaccines for celiac disease, and several working trials are underway. However, this new drug's creator, ImmusanT, based in Cambridge says that, unlike other vaccines, which prevent an infection, their drug, Nexvax2 works by changing the immune system so it no longer attacks gluten.
    Production on Nexvax2, began last week, Steven G. Richter, Microtest’s president and science director, told a local reporter. So far, ImmusanT has raised $20 million in investor capital to bring the vaccine to market. ...


    Jefferson Adams
    Celiac.com 04/10/2015 - Of course, a strict gluten free diet is still the only safe and effective treatment for celiac disease. However, new drugs in development, some of which are currently being tested on humans, might allow people with celiac disease to safely eat gluten again, at least in small amounts.
    To be fair, even if all goes smoothly, it will be a few years at least before we see such treatments on the market. Moreover, even though many early results have been encouraging, none have yet entered safety trials, the final step before Food and Drug Administration approval and commercial availability.
    Drugs currently under trial include an enzyme that splits the protein in wheat that triggers adverse reactions, into smaller harmless products, and another which promises...


    Jefferson Adams
    Celiac.com 08/21/2015 - Here's every celiac disease treatment currently in development in a single list:
    ALV003, by Alvine Pharmaceuticals, is a combination of two enzymes that break down gluten before it can provoke an immune reaction. The drug is a powder to be dissolved in water and taken before meals.

    ALV003 most recently passed a phase 2 clinical trial, results of which appeared in the June 2014 issue of Gastroenterology. Post-trial biopsies showed that ALV003 prevented intestinal damage in 34 volunteers with celiac disease who ate 2 grams of gluten each day for six weeks and also took the drug. Phase 2b, a 12-week trial, is now underway.
      AN-PEP, by DSM Food Specialties, is another enzyme that degrades gluten. AN-PEP is believed to work best when taken while gluten ...


  • Recent Activity

    1. - Bayb replied to Bayb's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      3

      Trying to read my lab results

    2. - Aussienae replied to Aussienae's topic in Coping with Celiac Disease
      65

      Constant low back, abdominal and pelvic pain!

    3. - trents replied to mishyj's topic in Coping with Celiac Disease
      3

      Why?

    4. - trents replied to mishyj's topic in Coping with Celiac Disease
      3

      Why?

    5. - mishyj replied to mishyj's topic in Coping with Celiac Disease
      3

      Why?


  • Celiac.com Sponsor (A19):



  • Member Statistics

    • Total Members
      121,221
    • Most Online (within 30 mins)
      7,748

    lortaine
    Newest Member
    lortaine
    Joined

  • Celiac.com Sponsor (A20):


  • Forum Statistics

    • Total Topics
      120.3k
    • Total Posts
      1m

  • Celiac.com Sponsor (A22):




  • Who's Online (See full list)

    • There are no registered users currently online

  • Celiac.com Sponsor (A21):



  • Popular Now

    • Kmd2024
      5
    • Nicola flaherty
      4
    • ItchyHell
      4
    • MMH13
      20
    • Moodiefoodie
  • Popular Articles

    • Scott Adams
    • Scott Adams
    • Scott Adams
    • Scott Adams
    • Scott Adams
  • Upcoming Events

×
×
  • Create New...