Celiac.com Sponsor (A1):



Celiac.com Sponsor (A1-m):


  • You've found your Celiac Tribe! Join our like-minded, private community and share your story, get encouragement and connect with others.

    💬

    • Sign In
    • Sign Up
  • Jefferson Adams

    Will a Pill Soon Enable Celiac Patients to Eat Gluten?

    Jefferson Adams
    0
    Reviewed and edited by a celiac disease expert.

    Photo: CC--doug88888
    Caption: Photo: CC--doug88888

    Celiac.com 01/16/2013 - Scientists are making progress on the creation of a pill that would allow people with celiac disease to safely eat gluten in much the same way that lactase pills allow people with lactose intolerance to eat dairy products without upsetting digestion.

    Photo: CC--doug88888As with lactase, the approach involves the use of an enzyme to break down the gluten that causes celiac symptoms.



    Celiac.com Sponsor (A12):






    Celiac.com Sponsor (A12-m):




    When people consume wheat, rye or barley, enzymes in the stomach break down gluten into smaller pieces, called peptides. For most people, these peptides are harmless. But for the 2 million-3 million Americans with celiac disease, the peptides trigger an autoimmune response and painful symptoms.

    Currently, the only way for people with celiac disease to avoid the autoimmune response and the accompanying symptoms is to avoid gluten altogether.

    However, Justin Siegel, Ingrid Swanson Pultz and colleagues think that an enzyme might be able to further break down the offending peptides in the stomach, thus permitting people with celiac disease to safely eat gluten-containing foods.

    Their efforts led to the discovery of a naturally occurring enzyme that has some of the ideal properties for doing so. They then used a computer to modify the enzyme in the laboratory so that it would do the job completely.

    The newly engineered enzyme, which they called KumaMax, breaks down more than 95 percent of gluten peptides associated with celiac disease in acidic conditions that mimic the stomach.

    Clearly, further research and trials are needed, but these early results make the new enzyme a strong candidate for oral use in the treatment of celiac disease.

    What do you think? Would you take spill that allowed your body to safely digest gluten from wheat, barley or rye without any of the symptoms or damage associated with celiac disease? Share your thoughts in the comments box below.


    Source:

    0

    User Feedback

    Recommended Comments



    Not sure about this; I don't like taking pills. Though I may consider this if I was eating out or going somewhere other than home. Then I could be sure that any contamination would be okay. At home, I don't have to worry. So yes maybe it would be useful when away from home where you are not sure about how careful they are being.

    Share this comment


    Link to comment
    Share on other sites

    95%? I'd need 100%. In practice, not just the lab. I'd also need to have the safety and efficacy of the enzyme well tested, and even then time periods and numbers tested would be small. Finally, at what cost? I'd distinguish between something to help for an accidental gluten ingestion, versus something for regular consumption like lactase has been promoted.

    Share this comment


    Link to comment
    Share on other sites

    digestive enzymes that break down the gluten peptide already exist but now PHARMA is trying to capitalize here and make people think the only way to get them is from your medical doctor!

    Share this comment


    Link to comment
    Share on other sites

    I use it as a safety thing when eating out in restaurants or over a friends for dinner. I've taken lactaid for years and don't find it cumbersome at all, sounds like this would be much the same.

    Share this comment


    Link to comment
    Share on other sites

    Would I take this pill? It depends. If it is 95% effective and I'm very sensitive to gluten, I still may experience troubling symptoms. Also, if the cost is high, as it likely will be for complex drug like this and companies needing to recoup their R&D investment, then I may wait for affordable generic versions with the added benefit of seeing if any rare adverse events emerge once the drug is on the market.

    Share this comment


    Link to comment
    Share on other sites

    With further testing, this could have real implications in giving celiacs on a gluten free diet a chance to travel/eat socially more freely. I think it would take a LOT of long term research to ensure 100% safety and put celiacs back on a gluten containing diet, but if this pill can disrupt the effects of small amounts of contamination for those on a gluten free diet, it could give us a lot more freedom to take "risks."

    Share this comment


    Link to comment
    Share on other sites



    Join the conversation

    You are posting as a guest. If you have an account, sign in now to post with your account.
    Note: Your post will require moderator approval before it will be visible.

    Guest
    Add a comment...

    ×   Pasted as rich text.   Restore formatting

      Only 75 emoji are allowed.

    ×   Your link has been automatically embedded.   Display as a link instead

    ×   Your previous content has been restored.   Clear editor

    ×   You cannot paste images directly. Upload or insert images from URL.


  • About Me

    Jefferson Adams is Celiac.com's senior writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University, and has authored more than 2,500 articles on celiac disease. His coursework includes studies in science, scientific methodology, biology, anatomy, medicine, logic, and advanced research. He previously served as SF Health News Examiner for Examiner.com, and devised health and medical content for Sharecare.com. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of the book "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.


  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):





    Celiac.com Sponsors (A17-m):




  • Related Articles

    Kim Hopkins
    Plan your meals:  It sounds simple, but it’s one that is often ignored.  Sit down before you do your weekly grocery run.  Know what you are going to make for each meal including snacks.  Find out what’s on sale before you make your weekly meal plan.  Stick to the list when you shop! Develop a file of dependable, go to gluten-free recipes.  My people report that, when they are short on time, that’s when they are likely to make extravagant purchases.  Take the thinking and guess work out of meal planning by looking through your file.  You can even write down the estimated cost of the meal. Eat foods that are naturally gluten free found at the regular g...

    Jefferson Adams
    Celiac.com 11/25/2011 - In solidarity with family members who have food allergies, many families enforce a voluntary ban on the food or foods in question. But is that an that a safe and advisable practice?
    A leading dietitian claims that people who avoid foods to which they are not allergic may have problems if they attempt to reintroduce those foods later on in life. Dietitian Arlene Normand says that banning food for those without allergies is not healthy, and could lead to later health complications. Normand specifically claims that that banning foods for the whole family, just because a family member has allergies to those foods, may leave one...

    Jefferson Adams
    Celiac.com 01/26/2012 - A Canadian woman is fighting a battle with the government of British Columbia to protect the services that allow her 18-year old daughter to live at home in Quesnel, B.C., with 24-hour care — much of it provided by Shelley McGarry herself.
    The woman's daughter, Chelsea McGarry already has a long list of challenges — Down syndrome, autism, early onset Alzheimer's disease, diabetes, and celiac disease, among other conditions.
    The problem is that Chelsea turns 19 in December, at which point her responsibility for her care transfers from Ministry of Children and Family to Community Living B.C., the government agency that pro...

    Jefferson Adams
    Celiac.com 08/29/2014 - Well, we haven’t had a good gluten-free celebrity dustup in a while, so I’m happy to report that the most recent shots have been fired by actor Charlize Theron, who called ‘b$#@@#$$’ on the non-celiac gluten-free diet fad in Hollywood.
    Talk show host Chelsea Handler asked Theron about her thoughts on the gluten-free cupcakes Handler sent her last Christmas.
    That prompt was enough for Theron to share her true feelings about both the cupcakes, and the whole (we assume she means ‘fad’) “gluten free” issue in general.
    “I just think that if you are gonna send a gift, let it be enjoyable. Why send me a very cupcake...