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  • Jefferson Adams

    Women with Untreated Celiac Disease Show Significant Impaired Bone Development

    Jefferson Adams

    Reviewed and edited by a celiac disease expert.   eNewsletter: Get our eNewsletter

    Celiac.com 06/15/2015 - It's well-documented that people with active celiac disease are more likely to have osteoporosis and increased risk of fractures. High-resolution peripheral quantitative computed tomography (HR-pQCT) allows for three-dimensional exploration of bone micro-architecture, including measurement of cortical and trabecular compartments, and providing detailed information on bone disease pathophysiology and fracture. Using HR-pQCT, research team recently set out to assess the volumetric and micro-architectural characteristics of peripheral bones. that is the distal radius and tibia, in adult pre-menopausal women with active freshly diagnosed celiac disease.

    Photo: CC--Ted EytanThe research team included María Belén Zanchetta, Florencia Costa, Vanesa Longobardi, Gabriela Longarini, Roberto Martín Mazure, María Laura Moreno, Horacio Vázquez, Fernando Silveira, Sonia Niveloni, Edgardo Smecuol, María de la Paz Temprano, Hui Jer Hwang, Andrea González, Eduardo César Mauriño, Cesar Bogado, Jose R. Zanchetta, an dJulio César Bai. They are variously affiliated with the IDIM, Instituto de Diagnóstico e Investigaciones Metabólicas, and with the Cátedra de Osteología y Metabolismo Mineral, Universidad del Salvador, Buenos Aires, Argentina.

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    For the study, their team prospectively enrolled 31 consecutive premenopausal women with newly diagnosed celiac disease (median age 29 years, range: 18–49) and 22 healthy women of similar age (median age 30 years, range 21–41) and body mass index. Using HR-pQCT, the team was able to successfully identify significant deterioration in the micro-architecture of trabecular and cortical compartments of peripheral bones.

    HR-pQCT revealed that most bone micro-architecture parameters were substantially reduced in celiac disease patients compared to a control group. Twenty-two patients showed symptomatic celiac disease. These patients had a greater bone micro-architectural deficit than those with sub-clinical celiac disease.

    Impaired bone micro-architecture could be one cause of diminished bone strength and higher risk of fractures seen in many celiac patients.

    The researchers are looking to conduct a follow-up of this group of patients. They want to know whether bone micro-architecture recovers with a gluten-free diet, and, if so, how quickly and to what extent.



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    Do you know what's worse than osteoporosis?  It's "near death" from severe malnutrition & HPT caused by the toxic effects of gluten.  Gluten is "poison".  Wheat also contains gliadin which is linked to type I Diabetes Mellitus, Fibromyalgia & numerous other inflammatory diseases.  

    Celiac disease is a hideous condition.  Food cross-reactors prevent the intake of foods containing: Yeast-Egg-Milk.  It took 3 months to stop "craving" wheat after I was forced for health purposes to stop consuming it.  There were no gluten-free products (cookies/mixes etc.) that did not contain egg or yeast or milk. After a few years the desire for "sweet" foods dissipated. 

    I have a diet much like that of ancient humans: meat, fruit, fresh vegetables.  Fortunately I found a "cold-pressed" extra-virgin olive oil to provide the much needed healthy fat.  The FDA does NOT require testing for residual toxins found "heat-processed" oils.  Cottonseed is has the highest % of pesticides.  Canola is extracted from a "poisonous plant". Canola, seed oils & flower oils are extracted using: Hexane (gasoline byproduct), bleach, defoaming agents, deodorizers (used to "MASK" the purification odor) from the extraction process.

    It may behoove people to be diligent "label-readers" & to limit or eliminate the processed foods containing "toxins" & grains in general especially wheat.   

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    I have been seeing that there is now research linking inflammation of the brain along with many other similar symptoms that link this with diabetes, but now also with Alzheimers Disease. Are there any studies on this? Alzheimers is being considered by some researchers as Diabetes 3 because of all the links between them. So, as Celiac is commonly linked to Diabetes and having similar symptoms, is Alzheimers Disease also to be found to be linking to Celiac as well? The research is saying Alzheimers can be prevented by a great deal to do with diet, exercise, sleep, and hormone treatment such as Male hormones = memory in men and female hormones = memory in women. Alzheimers seems to be an inflammatory disease with many similar systems and treatment as both Diabetes and Celiac diseases. Are those with Alzheimers at greater risk of being Celiac, and vice versa?

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  • About Me

    Jefferson Adams is Celiac.com's senior writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University, and has authored more than 2,500 articles on celiac disease. His coursework includes studies in science, scientific methodology, biology, anatomy, medicine, logic, and advanced research. He previously served as SF Health News Examiner for Examiner.com, and devised health and medical content for Sharecare.com. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of the book "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.

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