1056 Alvine Pharmaceuticals Closes a $21 Million Series A Financing for Research into Celiac Disease Treatment - Celiac.com
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Alvine Pharmaceuticals Closes a $21 Million Series A Financing for Research into Celiac Disease Treatment

Celiac.com 09/29/2006 - Alvine Pharmaceuticals, Inc., a biopharmaceutical company focused on developing pharmaceutical products for the treatment of celiac sprue, today announced the closing of a $21 million Series A financing. Sofinnova Ventures led the investment round with strong support from Prospect Venture Partners and InterWest Partners. Cargill Ventures and Flagship Ventures also participated in the financing.

"This financing brings together a premier group of investors committed to advancing the companys lead product candidate ALV001 into human clinical and safety trials," said Stanford Professor Chaitan Khosla, Ph.D., who co-founded the company. "Celiac sprue is a serious yet common immune disease that is triggered by gluten, a component of cereal grains found in most foods sold in the U.S. While under-diagnosed, as many as one in one hundred individuals suffer from celiac sprue, yet there is no drug therapy available. Alvines mission is to provide innovative drug therapies for this disease and to change the lives of its many patients," he continued.

"Sofinnova has known Chaitan since the early 90s when we worked together on behalf of Kosan Biosciences. Were thrilled to be working with him again on his current venture," commented Sofinnova Ventures General Partner Nicola Campbell, Ph.D. "Alvines lead products will be beneficial to the celiac market for the treatment of a neglected patient population. ALV001 has proven to be uniquely safe for patients with celiac sprue, an actuality that the management team and investors alike are proud of."

Joining Khosla in this venture are Alvine co-founders Blair Stewart, President and Kevin Kaster, Vice President of Corporate Development.

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Alvines platform is based on over six years of research, and an extensive intellectual property portfolio licensed from Stanford University and acquired from the Celiac Sprue Research Foundation.

The Alvine Board of Directors consists of: Nicola Campbell, Ph.D., General Partner, Sofinnova Ventures; Ilan Zipkin, Ph.D., Partner, Prospect Venture Partners; Nina Kjellson, Partner, InterWest Partners; and Chaitan Khosla, Wells H. Rauser and Harold M. Petiprin Professor in the School of Engineering; Professor of Chemical Engineering, Chemistry, and Biochemistry, by courtesy, of Stanford University.

About Alvine:
Alvine Pharmaceuticals, Inc., is a Palo Alto-based biopharmaceutical company dedicated to developing and commercializing therapeutics for the treatment of Celiac sprue. Alvines lead molecule, ALV001, is a protease designed to be consumed with food to detoxify the gluten that triggers the autoimmune response in celiac patients. Celiac sprue is believed to affect as many as two million people in the United States alone, many of whom have suffered the symptoms of the disease but have not yet been diagnosed.

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I workout, but with lighter weight than normal. I never go to failure. But being tired is not one my symptoms.

Well I took test for deficiencies today won't get the results till Tuesday then I can go from there.. road to recovery

Ask them for a copy of your results and find a good gastroenterologist in your area. Go there and give them the results. That's what I did. I didn't even bother with my GP. I got the results from the health fair and called a GI in Denver. My insurance didn't require a referral. My GI was the one who put me on the track to being accurately diagnosed. And regardless, you need to be hooked up with a good GI if you've got Celiac so that they can follow you.

Also, I had my bones checked a few months back (In January), and they were awesome. I'm still shocked at how well my body did with Celiac. I hear about all of my friends on here who had crazy horrible symptoms and I never did. I'm grateful. Because those ugly things would come eventually.

I work out regularly and I would say NO to working out if you have been glutened or are really tired. You know what happens to people who work out when they are really fatigued? They suffer injuries. I was not well enough to work out until I had been gluten free for 4 years but I am much older than you so I doubt it will take 4 years for you. Drop the work-outs for now and just go for walks outside when you feel better. The fatigue has to be better before you try to do gym work. I know you didn't want to hear that but I don't want you to end up injured, on top of everything else. Take care of yourself for now and let yourself heal!