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Dendritic Cell Subset Identified in Celiac Disease

Celiac.com 03/26/2007 - According to a recent Norwegian research report, the adverse immune response to gluten may be tied to a specific set of dendrite cells in the small intestine.

A team led by Dr. Melinda Raki set out to compare the antigen-presenting cells in the small intestine of patients with celiac disease versus those from normal individuals.

The study used multiple duodenal biopsy specimens from 14 patients with untreated celiac disease, 6 with treated celiac disease and 4 controls.

Antigen presenting cells are so termed because they present gluten to the T-cells, which then contribute to the inflammation that damages the villi in the intestinal lining of those with celiac disease.

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Researcher found that in the normal duodenal mucosa, about 20% of the HLA-DQ2 molecules associated with celiac disease were Cd11c+ dendritic cells. These dendritic cells accrued in the celiac lesions of the untreated celiac subjects.

When these CD11c+ cells were removed from the biopsy samples, they provoked an adverse gluten reaction in the T-cells.

The study indicates that a greater knowledge of antigen-presenting cells will yield a more complete understanding of the dynamics of celiac disease, the means by which inflammation occurs, and the means by which it can be controlled or avoided altogether.

Gastroenterology 2006;131:428-438.

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There is also a celiac center at UCLA - Dr Weiss

mnburis, I'm concerned about your symptoms, especially the diarrhea being so frequent. I experienced pellagra after prolonged diarrhea. The symptoms are diarrhea, dermatitis, dementia and death. Pellagra is a deficiency of niacin (B 3). With your vitamin D and B 12 already diagnosed as ...

thats so exciting! let me know if you need any help with finding gluten-free products or brands when you move here

I have had NO breath tests done. Just blood, stool, colonoscopy and endoscopy. I'm sorry. I'm feeling so discouraged. I just know its going to be put down to IBS. And I personally feel that IBS is a throw away diagnosis when no one wants to investigate further.

Also, have you been tested for H. Pylori infection? I think I have seen that many ulcers can be attributed to that. It is also diagnosed with a breath test. Hang in there. Many people have been in your shoes. I wish it were easier.