No popular authors found.
Ads by Google:

Categories

No categories found.


Get Celiac.com's E-Newsletter





Ads by Google:


Follow / Share


  FOLLOW US:
Twitter Facebook Google Plus Pinterest RSS Podcast Email  Get Email Alerts
SHARE:

Popular Articles

No popular articles found.
Celiac.com Sponsors:

Discovery of Key Genetic Risk Factor for Celiac Disease Offers Hope of Advances in Diagnosis and Treatment - Results Promise Better Diagnostics and Treatment for Celiac Disease

Celiac.com 06/26/2007 - The results of a study recently published in the online science journal Nature Genetics have revealed a previously unknown genetic risk factor for celiac disease. An international team of researchers set out to study the genetic causes of intestinal inflammatory disorders.

When the study began, it was well known that individuals with celiac disease have specific tissue types that identify wheat proteins. Why healthy individuals with the same tissue type failed to develop celiac symptoms or celiac disease remained unknown, and was a key question the team set out to answer. The team was led David van Heel, Professor of Gastrointestinal Genetics at Queen Mary, University of London. The Human Genome Project and the Hap Map Project played key support roles in the study.

The results show that a protective DNA sequence in a specific gene segment, generally found in healthy individuals are missing in people with celiac disease. The research team evaluated genome data of 778 individuals with celiac disease and 1,422 controls non-celiacs within the British, Irish and Dutch populations.

Key DNA Sequence Missing in Celiacs

Researchers discovered that, compared to people with celiac disease, healthy people more commonly have a DNA sequence in the interleukin-2 and interleukin-21 gene region that protects against celiac disease. Interleukin-2 and interleukin-21 are cytokine proteins that are secreted by white blood cells, and which control inflammation. In people with celiac disease, the protective DNA sequence most likely leads to lesser amounts of these cytokines being produced, which weakens the defense against intestinal inflammation.

Ads by Google:

Breakthrough in Better Understanding Risk Factors for Development of Celiac Disease

About 1 in 133 people develop the disease, but, so far, predicting those at risk to develop the disease has been haphazard at best. Present methods of genetic testing can only narrow down the search to about 30% of the general population. These results give doctors a means to discover what further genetic risk factors leave people vulnerable to developing celiac disease.

Queen Mary, University of London Press Release - Public release date: 10-Jun-2007

health writer who lives in San Francisco and is a frequent author of articles for Celiac.com.

Celiac.com welcomes your comments below (registration is NOT required).












Related Articles



1 Response:

 
Patrick McCormack
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
08 Feb 2008 8:28:10 AM PDT
It IS VERY GOOD INFORMATION




Rate this article and leave a comment:
Rating: * Poor Excellent
Your Name *: Email (private) *:




In Celiac.com's Forum Now:


Welcome! Here is a link to our Newbie 101 thread that you might find useful. I can only comment on those foods that I have in my home or have purchased. 1. Nutella is and it states it in the label. 2. Skippy PB is gluten-free (not stated, but ingrediants are). 3. ...

In the beginning, you might find ANY gluten free bread abhorrent. So, you might wait a few months to give yourself time to forget what wheat bread tasted like.

In my brief research, I did not find any public papers indicating villi blunting for Losartan specifically. There was research and a law suit on olmesartan (other celiac.com members have pointed out). Dr. Hart may have been making clinical observations or has access to medical research that is...

I did find a local store that carries the Canyon House brand and will give that a try. It can be tough as I live in a fairly rural area and we don't have a lot of the resources many of the more urban areas do. It is a 1 hour round trip just to get to the closest town with anything like a Trader ...

Hello, Often drugs that end in ?artan are ARBs, and they work by blocking the angiotensin receptors. I?m not sure what the exact difference is between the two medications you mention, though. Have you called the manufacturer of losartan to see if any of the fillers contain gluten? It might b...