No popular authors found.


Get Celiac.com's E-Newsletter

Categories

No categories found.







Ads by Google:


Questions? Join Our Forum:
~1 Million Posts
& Over 66,000 Members!



SHARE THIS PAGE:
Celiac.com Sponsors:

Do Adults with High Gliadin Antibody Concentrations have Subclinical Gluten Intolerance?

Please note that this study has no biopsy confirmation, so it can only be called gluten intolerance statistics. Its findings indicate that gluten intolerance may be relatively common in the general population.

AU - Arnason JA ; Gudjonsson H ; Freysdottir J ; Jonsdottir I ; Valdimarsson H
TI - Do Adults with High Gliadin Antibody Concentrations have Subclinical Gluten Intolerance?
LA - Eng
AD - Department of Immunology, National University Hospital, Reykjavik, Iceland.
SO - Gut 1992 Feb;33(2):194-7 AB - Gliadin antibodies of the IgG and IgA isotopes and IgG subclasses were measured in 200 adults who were randomly selected from the Icelandic National Register.

Ads by Google:

Those with the highest gliadin antibody concentrations were invited with negative controls to participate in a clinical evaluation. Neither the study subjects nor the physicians who recorded and evaluated the clinical findings were aware of the antibody levels. Significantly higher proportion of the gliadin antibody positive individuals reported unexplained attacks of diarrhea (p = 0.03), and IgA gliadin antibodies were associated with increased prevalence of chronic fatigue (p = 0.0037). The gliadin antibody positive group also showed significantly decreased transferrin saturation, mean corpuscular volume and mean corpuscular hemoglobin compared with the gliadin antibody negative controls. Serum folic acid concentrations were significantly lower in the IgA gliadin antibody positive individuals. On blind global assessment, 15 of the 48 participants were thought to have clinical and laboratory features that are compatible with gluten sensitive enteropathy, and 14 of these were in the gliadin antibody positive group (p = 0.013). Complaints that have not been associated with gluten intolerance had similar prevalence in both groups with the exception of persistent or recurrent headaches that were more common in the gliadin antibody positive group. These findings raise the possibility that a sub-clinical form of gluten intolerance may be relatively common.

The following chart summarizes the study:

No. Randomly Selected for Study No. Selected w/ High Gliadin No. w/ Gluten Sensitive Enteropathy No. w/ GSE & High Gliadin
200 ( = 100%) 48 ( = 24%) 15 ( = 7.5%) 14 ( = 7%)

Celiac.com welcomes your comments below (registration is NOT required).












Related Articles



1 Response:

 
jeff
Rating: ratingfullratingfullratingfullratingfullratingempty Unrated
said this on
28 Oct 2010 11:51:38 AM PST
This is a great explanation. There are several great research organizations out there researching this as well to gain even better understanding. You can actually participate in the research and get paid for your time if you are diagnosed with diseases like Celiac, and many others. The research helps to develop diagnostic tests and cures, and you are paid anywhere from $200 to $1000 every time you participate.




Rate this article and leave a comment:
Rating: * Poor Excellent
Your Name *: Email (private) *:




In Celiac.com's Forum Now:


This year I have to go easy. So I'm cooking a turkey thigh (assuming they sell those at the store), zucchini cooked with olive oil and salt, and homemade gravy. Etalia artisan style bread (boule), and pumpkin pie. Will space these things throughout the day as I can only eat small amounts at a tim...

Thanks kareng. Yoga is something I've always really loved and I'm pretty sure I'll feel better doing it. I like the flowy kind too, it's almost like a meditation. Slowly sounds good to me. I could put on some quiet music too or do a guided one. Light weights is a nice idea too tessa. It's l...

Is Non-Celiac Gluten Sensitivity and/or Celiac disease really Pellagra in disguise in the 21st Century? Whether to supplement or to not supplement by the Posterboy What to say? What not to Say? So many things to cover. . . yet so little time/room for it in only one post. Let me b...

I would be happy to email you all of my recipes that I've collected over the last 5 years for Thanksgiving (and my Christmas recipes if needed). I have some super easy (i.e make ahead and crockpot friendly) and tasty recipes for everything: turkey, stuffing, mashed potatoes, sweet potatoes, etc. ...

Wise words Hobbes. I heard something recently talking about how not to let constant demanding events consume you and stop you from moving towards your dreams. Celiac can definitely take a big chunk and time out of your life but it's not my purpose for being here on the planet. Focus is an excelle...