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Do Adults with High Gliadin Antibody Concentrations have Subclinical Gluten Intolerance?

Please note that this study has no biopsy confirmation, so it can only be called gluten intolerance statistics. Its findings indicate that gluten intolerance may be relatively common in the general population.

AU - Arnason JA ; Gudjonsson H ; Freysdottir J ; Jonsdottir I ; Valdimarsson H
TI - Do Adults with High Gliadin Antibody Concentrations have Subclinical Gluten Intolerance?
LA - Eng
AD - Department of Immunology, National University Hospital, Reykjavik, Iceland.
SO - Gut 1992 Feb;33(2):194-7 AB - Gliadin antibodies of the IgG and IgA isotopes and IgG subclasses were measured in 200 adults who were randomly selected from the Icelandic National Register.

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Those with the highest gliadin antibody concentrations were invited with negative controls to participate in a clinical evaluation. Neither the study subjects nor the physicians who recorded and evaluated the clinical findings were aware of the antibody levels. Significantly higher proportion of the gliadin antibody positive individuals reported unexplained attacks of diarrhea (p = 0.03), and IgA gliadin antibodies were associated with increased prevalence of chronic fatigue (p = 0.0037). The gliadin antibody positive group also showed significantly decreased transferrin saturation, mean corpuscular volume and mean corpuscular hemoglobin compared with the gliadin antibody negative controls. Serum folic acid concentrations were significantly lower in the IgA gliadin antibody positive individuals. On blind global assessment, 15 of the 48 participants were thought to have clinical and laboratory features that are compatible with gluten sensitive enteropathy, and 14 of these were in the gliadin antibody positive group (p = 0.013). Complaints that have not been associated with gluten intolerance had similar prevalence in both groups with the exception of persistent or recurrent headaches that were more common in the gliadin antibody positive group. These findings raise the possibility that a sub-clinical form of gluten intolerance may be relatively common.

The following chart summarizes the study:

No. Randomly Selected for Study No. Selected w/ High Gliadin No. w/ Gluten Sensitive Enteropathy No. w/ GSE & High Gliadin
200 ( = 100%) 48 ( = 24%) 15 ( = 7.5%) 14 ( = 7%)

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1 Response:

 
jeff
Rating: ratingfullratingfullratingfullratingfullratingempty Unrated
said this on
28 Oct 2010 11:51:38 AM PDT
This is a great explanation. There are several great research organizations out there researching this as well to gain even better understanding. You can actually participate in the research and get paid for your time if you are diagnosed with diseases like Celiac, and many others. The research helps to develop diagnostic tests and cures, and you are paid anywhere from $200 to $1000 every time you participate.




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I wish you lived near here, I have the greatest massage therapist she does Swedish style, She can loosen up the stressed tight muscles wonderfully, I am prone to getting knots in my shoulders and neck, so I have to have them worked out once a month otherwise they start to limit mobility and hurt.

Oh, I did.... was referred to pt which hasn't helped at all. My muscles are super tight and they supposedly are causing the back pain. No idea what originally caused the problem but it started a couple years ago and has just gotten worse.

Than you for your replies. You have given me a lot of think about?

Maybe you should have your back checked by a doctor, if the pain is constant and is not improving. You could be developing another AI issue like Ankylosing Spondylitis. At least consider trying to find the cause (compressions fractures, slipped disk, whatever).

A smart woman, our cycling lady is! I would heed her advice.