No popular authors found.
Ads by Google:

Categories

No categories found.


Get Celiac.com's E-Newsletter





Ads by Google:


Follow / Share


  FOLLOW US:
Twitter Facebook Google Plus Pinterest RSS Podcast Email  Get Email Alerts
SHARE:

Popular Articles

No popular articles found.
Celiac.com Sponsors:

Do Adults with High Gliadin Antibody Concentrations have Subclinical Gluten Intolerance?

Please note that this study has no biopsy confirmation, so it can only be called gluten intolerance statistics. Its findings indicate that gluten intolerance may be relatively common in the general population.

AU - Arnason JA ; Gudjonsson H ; Freysdottir J ; Jonsdottir I ; Valdimarsson H
TI - Do Adults with High Gliadin Antibody Concentrations have Subclinical Gluten Intolerance?
LA - Eng
AD - Department of Immunology, National University Hospital, Reykjavik, Iceland.
SO - Gut 1992 Feb;33(2):194-7 AB - Gliadin antibodies of the IgG and IgA isotopes and IgG subclasses were measured in 200 adults who were randomly selected from the Icelandic National Register.

Ads by Google:

Those with the highest gliadin antibody concentrations were invited with negative controls to participate in a clinical evaluation. Neither the study subjects nor the physicians who recorded and evaluated the clinical findings were aware of the antibody levels. Significantly higher proportion of the gliadin antibody positive individuals reported unexplained attacks of diarrhea (p = 0.03), and IgA gliadin antibodies were associated with increased prevalence of chronic fatigue (p = 0.0037). The gliadin antibody positive group also showed significantly decreased transferrin saturation, mean corpuscular volume and mean corpuscular hemoglobin compared with the gliadin antibody negative controls. Serum folic acid concentrations were significantly lower in the IgA gliadin antibody positive individuals. On blind global assessment, 15 of the 48 participants were thought to have clinical and laboratory features that are compatible with gluten sensitive enteropathy, and 14 of these were in the gliadin antibody positive group (p = 0.013). Complaints that have not been associated with gluten intolerance had similar prevalence in both groups with the exception of persistent or recurrent headaches that were more common in the gliadin antibody positive group. These findings raise the possibility that a sub-clinical form of gluten intolerance may be relatively common.

The following chart summarizes the study:

No. Randomly Selected for Study No. Selected w/ High Gliadin No. w/ Gluten Sensitive Enteropathy No. w/ GSE & High Gliadin
200 ( = 100%) 48 ( = 24%) 15 ( = 7.5%) 14 ( = 7%)

Celiac.com welcomes your comments below (registration is NOT required).










Related Articles



1 Response:

 
jeff
Rating: ratingfullratingfullratingfullratingfullratingempty Unrated
said this on
28 Oct 2010 11:51:38 AM PDT
This is a great explanation. There are several great research organizations out there researching this as well to gain even better understanding. You can actually participate in the research and get paid for your time if you are diagnosed with diseases like Celiac, and many others. The research helps to develop diagnostic tests and cures, and you are paid anywhere from $200 to $1000 every time you participate.




Rate this article and leave a comment:
Rating: * Poor Excellent
Your Name *: Email (private) *:




In Celiac.com's Forum Now:


Oh good luck with your challenge and I hope you're able to feel better soon! Yes, I am well aware of Michael Marsh and his thoughts and they are certainly in the back of my mind. I was on gluten for 5 months when I had the most recent antibody testing. Admittedly my TTG was the high...

That is true most people on the board do refer for Endoscopy and are responsible in their replies to people who are initially reaching out. But I did have experiences where some folks will tell people that certain tests are only positive with celiac disease. Which is not the case, so I'm just r...

Yes!!!! My best advice to expedite healing is to NOT eat out until you are feeling great and really think you have mastered the diet. If you must eat out, use a site like "Find Me Gluten Free" and select only those restaurants reviewed by celiacs. Otherwise pack your own food and eat at superm...

Why? Why bother to get tested? A gluten challenge can be brutal and long (8 to 12 weeks for the blood test and 2 to 4 weeks for the endoscopy): http://www.cureceliacdisease.org/faq/what-is-a-gluten-challenge/ I just had anemia which prompted my doctor to run a celiac panel. I waited ...

People here are told to go to a gastroenterologist for an endoscopy if they show high on any one test. They are not told they have celiac. Weak high numbers can be other things, but strong high numbers are celiac most of the time. That's what my gastro told me. As nobody here is a doctor we can o...