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Natural Killer Cell Activity in Celiac Disease - Czech Republic

Castany M, Nguyen H, Pospisil M, Fric P, Tlaskalova-Hogenova H
Natural killer cell activity in coeliac disease: effect of in vitro treatment on effector lymphocytes and/or target lymphoblastoid, myeloid and

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other parts of the body. It also produces secretions and excretions that aid in assimilation.
'); return false">epithelial cell lines with gliadin
Folia Microbiol, 1995 (Praha) 40; 6: 615-620.

In this study researchers tested the levels of natural killer cell activation in normal people and compared the results with treated celiacs, and found no significant difference. However, after exposing the celiacs blood to gliadin for thirty minutes the researchers found a reduced activation of natural killer cells, which is the bodys first line of defense against malignancy. These results provide further support to the theory that gluten is a carcinogen to celiacs.

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2 Responses:

 
LouClements
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said this on
26 Jun 2010 1:21:05 AM PDT
I was just diagnosed with celiac disease a few weeks ago. Later I had a blood test, where I found out that my natural kill cells were next to nothing. According to the doctor a normal number would be a least 100, to have twenty was bad. My test results said I had less that 5. So, my doctor started me on immune globulin shots to try to bring up natural kill cell numbers. I am also on a gluten-free diet. So, hopefully I am going to see some changes.

 
LouClements
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said this on
28 Jun 2010 8:42:43 PM PDT
I found another group of doctors that did a similar test to the 1995 test that is talked about above. The name of the doctors Grose RH, Thompson FM, Cummins AG. in Department of Gastroenterology and Hepatology, The Queen Elizabeth Hospital, University of Adelaide, Woodville South, SA 5011, Australia. 2007. Here is a link to those results "Deficiency of 6B11+ invariant NK T-cells in celiac disease" I myself have celiac disease, and my last blood test shows that I have very low Natural killer cells way below the normal number. I wonder if that could be a precursor to intestinal cancer? I hope not. . .




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Wish I could give you a hug. Unfortunately I know how that feels with Neurologists, Internists, Endocrinologists, Rheumatologists, GIs..... I got so tired of crying my drive home after refusing yet another script for Prozac. I do hope your GI can give you some answers even if it is just to rule out other possible issues. Keep on the gluten and we are here for you.

It is too bad that so often a full panel isn't done. Glad your appointment got moved up and hopefully you will get a clearer answer from the GI. Do keep eating gluten until the celiac testing is done. Once the testing is done do give the diet a good strict try. Hang in there.

That makes sense...I cried with relief when I got my diagnosis just because there was finally an answer. Please know that you are not weak or crazy. Keep pushing for testing. It could still be celiac, it could be Crohns. Push your Dr's to figure this out. Best wishes.

Thank you all very much. I actually cried when I got the answer. I wanted an explanation that I could "fix." Now I'm back to thinking I'm just weak and possibly crazy. I know I'm not crazy, but you know.

From what I have read online there is about a 1-3% chance of getting a false positive for celiac disease from a blood test. Was it a blood test that you got done? It may be worth your while to get a biopsy or more testing just to confirm it. I know being gluten free is a pain but it is better than getting cancer or other auto immune disorders.