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Natural Killer Cell Activity in Celiac Disease - Czech Republic

Castany M, Nguyen H, Pospisil M, Fric P, Tlaskalova-Hogenova H
Natural killer cell activity in coeliac disease: effect of in vitro treatment on effector lymphocytes and/or target lymphoblastoid, myeloid and

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other parts of the body. It also produces secretions and excretions that aid in assimilation.
'); return false">epithelial cell lines with gliadin
Folia Microbiol, 1995 (Praha) 40; 6: 615-620.

In this study researchers tested the levels of natural killer cell activation in normal people and compared the results with treated celiacs, and found no significant difference. However, after exposing the celiacs blood to gliadin for thirty minutes the researchers found a reduced activation of natural killer cells, which is the bodys first line of defense against malignancy. These results provide further support to the theory that gluten is a carcinogen to celiacs.

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2 Responses:

 
LouClements
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said this on
26 Jun 2010 1:21:05 AM PST
I was just diagnosed with celiac disease a few weeks ago. Later I had a blood test, where I found out that my natural kill cells were next to nothing. According to the doctor a normal number would be a least 100, to have twenty was bad. My test results said I had less that 5. So, my doctor started me on immune globulin shots to try to bring up natural kill cell numbers. I am also on a gluten-free diet. So, hopefully I am going to see some changes.

 
LouClements
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said this on
28 Jun 2010 8:42:43 PM PST
I found another group of doctors that did a similar test to the 1995 test that is talked about above. The name of the doctors Grose RH, Thompson FM, Cummins AG. in Department of Gastroenterology and Hepatology, The Queen Elizabeth Hospital, University of Adelaide, Woodville South, SA 5011, Australia. 2007. Here is a link to those results "Deficiency of 6B11+ invariant NK T-cells in celiac disease" I myself have celiac disease, and my last blood test shows that I have very low Natural killer cells way below the normal number. I wonder if that could be a precursor to intestinal cancer? I hope not. . .




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