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In vitro Model of the Pathogenesis of Celiac Disease
Oberhuber G, Schwarzenhofer
M, Vogelsang H
Dig Dis 1999 Nov- Dec;16(6):341-4
of Clinical Pathology, University of Vienna, Vienna, Austria.
The in vitro challenge of duodenal mucosa with gliadin is a
useful model to reproduce the immunological features of celiac
disease (CD) and allows the study of early pathogenetic events
in this disease. With this model it was shown that antigens
such as ICAM-1 and HLA-DR are upregulated as early as 1-2 h
after gliadin challenge in patients with CD. After 24 h the
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Potential Celiac Patients Provide a Model of Celiac Disease Pathogenesis
People with potential celiac disease have similar HLA, and positive anti-transglutaminase antibodies, but do not suffer damage to small intestinal mucosa.... [READ MORE]
In 1994 I was diagnosed with celiac disease, which led me to create Celiac.com in 1995. I created this site for a single purpose: To help as many people as possible with celiac disease get diagnosed so they can begin to live happy, healthy gluten-free lives. Celiac.com was the first site on the Internet dedicated solely to celiac disease. In 1998 I foundedÂ The Gluten-Free Mall, Your Special Diet Superstore!, and I am the co-author of the book Cereal Killers, and founder and publisher of Journal of Gluten Sensitivity.View all articles by Scott Adams
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