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In vitro Model of the Pathogenesis of Celiac Disease

Oberhuber G, Schwarzenhofer M, Vogelsang H
Dig Dis 1999 Nov- Dec;16(6):341-4

Department of Clinical Pathology, University of Vienna, Vienna, Austria. The in vitro challenge of duodenal mucosa with gliadin is a useful model to reproduce the immunological features of celiac disease (CD) and allows the study of early pathogenetic events in this disease. With this model it was shown that antigens such as ICAM-1 and HLA-DR are upregulated as early as 1-2 h after gliadin challenge in patients with CD. After 24 h the

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highly vascular layer of connective tissue under the basement membrane lining a layer of a membranous cellular tissue that covers a free surface or lines a tube or cavity of an animal body and serves especially to enclose and protect the other parts of the body, to produce secretions and excretions, and to function in assimilation.'); return false">lamina propria contained CD4+ T cells expressing the IL-2 receptor alpha-chain, which is a sign of activation. Intraepithelial lymphocytes increased in number and showed proliferative activity. After in vitro stimulation with gliadin, endomysial antibodies were found in the supernatant of the cultured mucosa from patients with celiac disease following a gluten-free diet. This supported the notion that endomysial antibodies are at least in part produced locally. The model was also successfully used to identify toxic constituents of gliadin. Presently, organ culture is not commonly used for diagnostic purposes.

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We freeze portions in a regular freezer zip lock bag.

That sounds good. Do you have a machine that seals without air or do you just use bags? Is it possible to buy bags only? I remembered the other type of froz food I sometimes get - Saffron Road.

You can always check to see how long the lab order lasts, if you'd like to continue eating gluten longer.

Might be something else in there, perhaps he ate something else with gluten, something was mixed in the chips, the chips were flavored or in a snack mix with pretzels. I get that way with gluten, but the last 2 times the gut issues render me unable to argue like that but I do go Mr. Hyde like =. ...

I hate to say it and be Mr. Negative ass here. But I had this exact same thought about having kids, I do not wish any kids I have to have my AI issues, and decided I would wait a few decades if need be for the new gene editing things they are working on so we can have them changed. Call me crazy.