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Celiac Disease Vaccine Trials Slated for 2009

Celiac.com 12/18/2008 - Celiac disease is a life-long autoimmune disease. When people with celiac disease consume the gluten proteins found in wheat, rye and barley they damage the lining of the gut, which prevents normal digestion and absorption of food.

There is currently no cure for the celiac disease. The only treatment is life-long adherence to a strict gluten-free diet. If a gluten-free diet is not followed, the disease can ultimately lead to ill health and life-threatening conditions including malnutrition, osteoporosis, bowel cancer, and may cause infertility problems.

The charity group Coeliac UK, recently hosted a conference at the Royal Society of Arts in central London where, among the latest findings in celiac disease research, they announced progress on the development of a possible vaccine for the condition.

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Dr. Bob Anderson of the Autoimmunity and Transplantation Division of Australia’s Walter and Eliza Hall Institute has led a research team that has isolated the toxic elements of gluten, paving the way for a possible vaccine that will suppress or prevent gluten toxicity. The research indicates that the toxic, autoimmune response in celiac patients exposed to wheat is triggered by just few dominant peptides in the gluten protein. This small number of offending peptides makes it exponentially easier for researchers to develop a vaccine.

Dr. Anderson is a joint founder and CEO of Nexpep, an Australian company that is actively working to develop a vaccine to treat celiac disease. Dr. Anderson’s team has created a peptide-based therapeutic vaccine to treat the main problem T-cell epitopes of gluten. The vaccine has the potential to treat at about 80% of people with celiac disease and having the appropriate genetic background. Similar to traditional desensitization therapy for allergies, the peptide-based vaccines are given in multiple small doses over a course of injections in an effort to create immune tolerance not only to the selected gluten fragments, but also lower the toxicity of related toxic gluten molecules.

Nexpep is currently raising capital for a clinical trial program for a peptide-based therapeutic vaccine and intends to commence a Phase 1 clinical trial in the first half of 2009.

Reference:
http://www.medicalnewstoday.com/articles/131745.php

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18 Responses:

 
Michelle Witham
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
01 Jan 2009 9:48:49 AM PDT
Being New Year's Day - our only wish is that a cure will be found for Celiac Disease and with this promising vaccine it gives us hope again for our 9 year old grandson who was diagnosed with both Diabetes type 1 and Celiac at age of 3...keep up the good work and Happy New Year!

 
Patty Cook
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said this on
01 Jan 2009 12:47:45 PM PDT
Excellent news, I hope this vaccine works! I would try it.

 
Hilda T Brower
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said this on
01 Jan 2009 3:53:06 PM PDT
Thank you so much for bringing the latest international research news to those of us who have gluten intolerance. I suspect it is more up-to-date than what the vast majority of gastroenterologists read.

 
Eugene Brogan
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said this on
01 Jan 2009 6:50:24 PM PDT
This article was very interesting.

 
Eugene Brogan
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said this on
01 Jan 2009 6:50:25 PM PDT
This article was very interesting.

 
Kristina Quinn
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said this on
02 Jan 2009 8:50:59 AM PDT
It finally gives me hope! My two very young children who have both Celiac disease and Type 1 Diabetes, may actually get to live a somewhat normal life like other kids. It brings tears to my eyes!!
THANK YOU !!!!!

 
Mayank Agarwal
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said this on
03 Jan 2009 3:15:49 AM PDT
This news gives hope to many celiac patients. Thanks for updating the latest developments.

 
Heather
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said this on
03 Jan 2009 12:40:54 PM PDT
I am hopeful this vaccine works! What wonderful news it would be for us Celiacs!

 
Misty Cleeton
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said this on
03 Jan 2009 10:57:06 PM PDT
This is an excellent idea. It would be great to have my daughter be able to eat "normal" food without getting sick! Keep up the research!

 
Joanne
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said this on
04 Jan 2009 4:29:31 PM PDT
Most interesting! What appropriate "genetic background" would make one eligible for this proposed vaccine?

 
Roberta Wall
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said this on
04 Jan 2009 8:12:23 PM PDT
Sounds almost too good to be true! Let's keep our fingers crossed that it works. Sign me up!

 
Amy Thielen
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said this on
04 Jan 2009 8:26:38 PM PDT
It would be a blessing that this vaccine would help those with Celiac. My 4 year old daughter was diagnosed at 3 years and 4 months old. She only weighed 21 lbs. and was only 33 inches tall. She is doing great with the acceptance part of having Celiac Disease, but it still breaks her heart when she sees other children in her preschool having snacks that she at one time could eat. I have another daughter who will be 3 next week, but does not have Celiac. This vaccine would be a miracle. As a mom, it breaks my heart to see her tears when she talks about her preschool friends.

 
Roxanne Barco
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said this on
12 Jan 2009 4:33:54 AM PDT
The only thing you left out was how to get involved in this trial...I would love to participate if they need volunteers!

 
Audrey Elderkin
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said this on
21 Jan 2009 10:14:16 AM PDT
The possibility of a vaccine is the first ray of hope I have had since being diagnosed in 2003. My son and great-niece also are celiacs. I would be willing to participate in a study on the vaccine.

 
gail zamberlin
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said this on
30 Jan 2009 11:22:16 PM PDT
I am very hopeful as we have a 19 year old son that does not stay on his diet at all, he's very thin and as parents we are very concerned.

 
Gloria Brown
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said this on
01 Feb 2009 8:09:28 PM PDT
My experience of Celiac is not as an allergy, but an inability to metabolize gluten from genetically not producing the required enzymes to do so. Compromising of the autoimmune system has seemed more related to the malnutrition which results from this.

 
Cheri Young
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said this on
23 Apr 2009 7:07:26 AM PDT
This is good news. I have had celiac for six years but anyone with Celiac would agree, six years is six years too long as this is a difficult way to live. So, I really hope for a 'cure' soon.

 
Noelle
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said this on
05 Oct 2009 12:47:39 AM PDT
Very interesting however my GI did not know anything about it and asked for a copy of the article and I haven't heard from anyone yet even though I replied to the email and signed up for the research.
Thank you




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I would not worry. Things might resolve on the gluten free diet as celiac disease does impact fertility in many ways. I hit perimenopause at 40. It lasted over a decade (the range of years varies from person to person) and I experienced every single perimenopause symptom (on and off) in the book. I was diagnosed with celiac disease after I went though menopause because of anemia that would not resolve. You could ask your GP/PCP to order a hormonal panel (include thyroid) if you see him/her sooner. This will let you know if you are starting perimenopause. My Mom breezed through menopause. Not me!!!!!

.." Gluten Free Watchdog we have been testing a wide variety of products with the Nima Sensor. It is very difficult to put the results of testing completed to date into proper context due to the lack of a published validation report on this device. One goal of our testing is to provide recommendations for consumer use of the Nima Sensor. This is proving to be impossible at this time. In the opinion of Gluten Free Watchdog the Nima Sensor was released into the marketplace prematurely. Given the current state of development of this sensor, Gluten Free Watchdog cannot support its use by the gluten-free community at this time...." https://www.glutenfreewatchdog.org/news/gluten-free-watchdogs-position-statement-on-consumer-use-of-the-nima-sensor-to-test-food-for-gluten/

https://www.glutenfreewatchdog.org/news/gluten-free-watchdogs-position-statement-on-consumer-use-of-the-nima-sensor-to-test-food-for-gluten/ "t Gluten Free Watchdog we have been testing a wide variety of products with the Nima Sensor. It is very difficult to put the results of testing completed to date into proper context due to the lack of a published validation report on this device. One goal of our testing is to provide recommendations for consumer use of the Nima Sensor. This is proving to be impossible at this time. In the opinion of Gluten Free Watchdog the Nima Sensor was released into the marketplace prematurely. Given the current state of development of this sensor, Gluten Free Watchdog cannot support its use by the gluten-free community at this time."

Yeah, I was pretty surprised. However, lots and lots of fantastic wine and gin. Even the house wine at a pub is going to be a nice French or Spanish something. Also drank a lot of port. And they take their gin super seriously there, some really good stuff. The closest I got to having a beer was trying some gin distilled from geuze (wild-fermented beer). Very nice. Make up for the lack of beer by eating all the fries.

This sounds familiar. Does the pain feel like its actually in your ribs, sore when you press on it? It could be costochondritis, which is inflammation of the cartilage between your ribs. It seems to be one of those weird things that tends to affect celiacs, could be a symptom of glutening or brought on by something else. I had a bad case of it a few months after going gluten free. Started as just a weird ache, and one morning it felt like I was being stabbed. Spent all day in emergency while they ruled out heart issues. Anti-inflamatories helped and it went away after a few days. Never came back that bad again. It could also just be heartburn-type symptoms triggered by gluten. I would see a doctor though, because you want to rule out whether its your heart or something. You're still early in your healing process, so not only are you probably not an expert at the gluten-free diet yet, but your body is readjusting to the new reality and doing all kinds of weird stuff. Hopefully this will resolve soon and not be a regular occurrence. It would only have a connection to your bowel issues in that it could be yet another fun affect of Celiac disease. Good luck and feel better soon!