No popular authors found.


Get Celiac.com's E-Newsletter

Categories

No categories found.







Ads by Google:


Questions? Join Our Forum:
~1 Million Posts
& Over 66,000 Members!



SHARE THIS PAGE:
Celiac.com Sponsors:

Mayo Study Supports Hapten-carrier Theory for the Origin of anti-tTG IgA

Celiac.com 03/26/2009 - The recent discovery that people with celiac disease harbor antibodies  that are specific for deamidated gliadin peptides (DGP), which are the product of tTG binding to gliadin peptides, offers a chance to examine the connection between the production of anti-tTG IgA and the antibodies against DGP in celiac patients.

A group of researchers led by Doctors Marietta, Rashtak, and Murray from the Mayo Clinic in Rochester, MN recently set out to make just such an examination, and a report on their study appears in the February issue of the World Journal of Gastroenterology.

Their data show that the blood level of anti-tTG IgA shares a significant connection with the blood level of anti-DGP of both the IgG and IgA isotypes in people with untreated celiac disease. The same data showed only a weak connection between the production of anti-tTG IgG and anti-DGP IgG/IgA.

Ads by Google:

Moreover, the results show that the immune response by T and B cells to deamidated gliadin differs at the most basic level from the immune response by T and B cells to tissue transglutaminase in celiac patients.

Their results also indicate, however, that the immune responses against deamidated gliadin and tTG are substantially connected, and thereby offer support for the hapten-carrier theory for the origin of anti-tTG IgA.

World Journal of Gastroenterology; February, 2009.

Celiac.com welcomes your comments below (registration is NOT required).












Comments




Rate this article and leave a comment:
Rating: * Poor Excellent
Your Name *: Email (private) *:




In Celiac.com's Forum Now:


I have Julian Bakery Bars, Miracle Noodle MRE, I also have cans of freeze dried eggs. Gluten Free Emergency kits, Mountain House, Thrive, and Augason Farms (used to) have gluten free options of freeze dried foods. Make sure you check the box or look at the gluten-free versions of selections but t...

Almond flour is a VERY common one, look up recipes yourself, I have used coconut for a softer breading, works well, I have a customer at my bakery who claims she loves dipping her chicken in chia seeds then frying them...bit extra crunchy. I have used bean chips like Beanitos and Beanfields fla...

For chicken and fish I have always dipped them in regular all purpose flour or breadcrumbs but seeking a healthier option, any ideas please?

Thank you for all of the info/advice. From a Psoriatic standpoint I had to eat healthier no matter what so my diet changes will need to be focused on that. It's just a few simple foods I need to get clear on, maybe you can advise on this please? Is it ok for a Celiac to eat regular eggs or would ...

Beans and legumes do contain lectins. I am not sure if pressurized cooking really removes them (and I cook with one). I would look for scientific research and not a blog to back this up. If you suspect lectins are an issue for you and are willing to experiment, then completely remove them for...