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Mayo Study Supports Hapten-carrier Theory for the Origin of anti-tTG IgA

Celiac.com 03/26/2009 - The recent discovery that people with celiac disease harbor antibodies  that are specific for deamidated gliadin peptides (DGP), which are the product of tTG binding to gliadin peptides, offers a chance to examine the connection between the production of anti-tTG IgA and the antibodies against DGP in celiac patients.

A group of researchers led by Doctors Marietta, Rashtak, and Murray from the Mayo Clinic in Rochester, MN recently set out to make just such an examination, and a report on their study appears in the February issue of the World Journal of Gastroenterology.

Their data show that the blood level of anti-tTG IgA shares a significant connection with the blood level of anti-DGP of both the IgG and IgA isotypes in people with untreated celiac disease. The same data showed only a weak connection between the production of anti-tTG IgG and anti-DGP IgG/IgA.

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Moreover, the results show that the immune response by T and B cells to deamidated gliadin differs at the most basic level from the immune response by T and B cells to tissue transglutaminase in celiac patients.

Their results also indicate, however, that the immune responses against deamidated gliadin and tTG are substantially connected, and thereby offer support for the hapten-carrier theory for the origin of anti-tTG IgA.

World Journal of Gastroenterology; February, 2009.

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Read this posted on the FDA.gov site: https://www.fda.gov/food/guidanceregulation/guidancedocumentsregulatoryinformation/allergens/ucm362880.htm

Color me confused. I went to Costco yesterday and there were 2 products there that had GLUTEN FREE plastered on the box but then in the ingredients was a: May contain wheat. How is this possible? How can they still put gluten-free on the box? We should be able to trust gluten-free labeling no?? And second question: How many of you would still buy that item? I REALLY wanted to buy the Island Way Sorbet for my daughter as it is her FAVE. But I didn't want to take the risk. Maybe when she is healthier? I mean it is SORBET?! LOL So frustrating!

JMG I have never laughed so hard! This was the best epic comment I've read! Thankyou so much! Your all teaching me so much! Love the 'my glass to go' idea!! I will be adopting this... can't believe the mucky glasses we must be drinking from! Shocking! Im still baffled how so many people don't understand cross contamination i.e. The crumbs on the work surface to cut the lime for your tasty beverage! Your all amazing Thankyou x

Yes! I never really had GI symptoms, but I did have palpitations and restless leg syndrome from anemia. These went away within the first month. But myalgia and joint aches aren't better after 1 year. Waiting to get my antibodies re-tested and see if they're negative.....

I will just share an experience I had..... I went to a steak house where there weren't a lot of safe options for me. So, I decided just to order a drink and eat later. I asked the bar tender about how they made their margaritas - fresh lime juice, fresh orange juice and gluten free tequila. gluten-free all the way. My husband went back to order for me and noticed that the bartender was juicing the limes and serving bread to the customers at the bar at the same time. I would have totally drank that margarita had he not seen him doing that. I decided to skip the margarita because of the high chance of CC