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Higher Rates of Heart Condition for Some Celiac Kids

Celiac.com 04/20/2009 - Faced with cases of idiopathic dilated cardiomyopathy that seemed to coincide with celiac disease, a team of Turkish researchers recently set out to determine if a possible connection exists between the two conditions.

The team was made up of Tugcin B. Polat, Nafiye Urganci, Yalim Yalcin, Cenap Zeybek, Celal Akdeniz, Abdullah Erdem, Elnur Imanov, and Ahmet Celebi, affiliated with the Department of Pediatric Cardiology, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Hospital, and/or with the Clinic of Pediatrics, Sisli Etfal Hospital, Istanbul, Turkey.

To date, little has been studied about cardiac function specifically as it relates to celiac disease. The researchers undertook their study to assess cardiac functions using Tissue Doppler Echocardiography in patients with celiac disease.

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The team evaluated 45 clinically stable patients. the time of echocardiographic evaluation, 25 patients showed positive serum IgA Antiendomysial Antibody levels (Group 1), 20 patients showed negative serum IgA Antiendomysial Antibody levels (Group 2). 30 healthy, disease-free children served as a control group.

Group 1 showed substantially lower myocardial systolic wave velocity of the mitral annulus (p < 0.001), while Group 2 showed slightly longer myocardial precontraction and contraction times compared to controls (p = 0.015, p = 0.044, respectively).

Researchers noted a negative association between the serum IgA Antiendomysial Antibody levels and myocardial systolic wave levels for all subjects (r =−0.633; p < 0.001). A myocardial systolic wave velocity of <8.9 cm/s showed 92% sensitivity and 80% specificity in anticipating patients with positive serum IgA Anti-endomysial Antibody levels.

The team concluded that children with celiac disease coupled with prominent serum IgA Anti-endomysial antibody reactivity, show higher rates of subclinical systolic dysfunction of the left ventricle. They also noted that Tissue Doppler echocardiography offers a helpful quantifiable indicator for cardiac monitoring of disease during follow up.

Digestive and Liver Disease 40 (2008) 182–187

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1 Response:

 
DebbieBoswell
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said this on
03 May 2009 4:32:45 PM PDT
There was little usable information for me to use or pass on to my sons physician - since my son does have celiac the article caught my eye - but now that it did what to do with it?!




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The reason they set the limit at 20ppms is that through scientific study, they have proven that the vast majority of people with Celiac Disease do not have an autoimmune reaction to amounts below that......it is a safe limit for most. Also, just because that limit is set at 20ppms, does not mean that gluten-free products contain that amount of gluten. Testing for lower levels becomes more expensive with each increment down closer to 0-5ppms, which translates into higher priced products. Unless you eat a lot of processed gluten-free food, which can have a cumulative affect for some, most people do well with the 20ppm limit.

I'm in the Houston area so I'm assuming there are plenty of specialists around, though finding one that accepts my insurance might be hard. This might sound dumb, but do I search for a celiac specialist?? I'm so new to this and want to feel confident in what is/isn't wrong with my daughter. I'm with you on trusting the specialist to know the current research.

Hi VB Thats sounds like a good plan. Would it help to know that a frustrating experience in seeking diagnosis isn't unusual With your IGG result I'm sure a part of you is still wondering if they are right to exclude celiac. I know just how you feel as I too had a negative biopsy, but by then a gluten challenge had already established how severely it affected me. So I was convinced I would be found to be celiac and in a funny way disappointed not to get the 'official' stamp of approval. Testing isnt perfect, you've already learned of the incomplete celiac tests offered by some organisations and the biopsy itself can only see so much. If you react positively to the gluten free diet it may mean you're celiac but not yet showing damage in a place they've checked, or it may be that you're non celiac gluten sensitive, which is a label that for a different but perhaps related condition which has only recently been recognised and for which research is still very much underway. We may not be able to say which but the good news is all of your symptoms: were also mine and they all resolved with the gluten free diet. So don't despair, you may still have found your answer, it just may be a bit wordier than celiac! Keep a journal when you're on the diet, it may help you track down your own answers. Best of luck!

Run to the nearest celiac disease specialty center if you can. Especially with conflicting doc opinions. Where do you live? Honestly, I test positive to only the DGP and the newest research on its specificity is a mixed bag. My recent scope did not show "active" celiac disease but only a slight increase in IELs. I am waiting for my post biopsy appointment with the Celiac specialist next month. But I've been through a couple of GI'S locally and honestly I feel it was definitely worth going to a specialist. Especially when you have some positive blood work but a normal biopsy the doctors really go back and Forth on diagnosis and never really know for certain. Unfortunately given the above I just said I probably still do not know for certain. Sigh. But I trust the specialist to be at the top of his game on the research and at least I can feel confident and comfortable in what his opinion may be next month.

That's a great list with such great info! Do you eat at Shucks?