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Anti-infectious and Autoimmune-associated Autoantibodies in Patients with Type I Diabetes Mellitus and Celiac Disease

Celiac.com 09/24/2009 - Could a reduced level of antibodies against infectious agents indicate a protective role for such infections in T1DM development in susceptible individuals? Recent research points in that direction. Type 1 diabetes mellitus (T1DM) is an autoimmune disease with intricate and poorly understood associations between genetic and environmental factors.

A joint Israeli-Colombian research team recently set out to examine the connections between anti-infectious antibodies and autoimmune-associated autoantibodies in patients with Type I diabetes mellitus and their close family members. Among other things, their findings confirmed a strong association between celiac disease and Type 1 diabetes mellitus.

The research team was made up of Ilan Krause, Juan Manuel Anaya, Abigail Fraser, Ori Barzilai, Maya Ram, Verónica Abad, Alvaro Arango, Jorge García, and Yehuda Shoenfeld. The team compared levels of antibodies to numerous infectious agents and of autoimmune-associated antibodies between Colombian T1DM patients, their close family members and healthy control subjects.

T1DM patients showed substantially reduced levels of antibodies against several infectious agents, including: cytomegalovirus (P= 0.001); Epstein-Barr virus (P= 0.02); Helicobacter pylori (P= 0.01); and Toxoplasma (P= 0.001).

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T1DM patients showed markedly elevated levels of IgG-anti-gliadin antibodies (P= 0.001) and IgG-antitissue transglutaminase antibodies (P= 0.03), and a marginal connection with anti-centromere antibodies (P= 0.06).

T1DM patients also showed a reduced level of antibodies against infectious agents that may be associated with their younger ages, but could also indicate a protective role for such infections in T1DM development in susceptible individuals.

The results reinforce the connection between T1DM and celiac disease, though the
possible connection with the anti-centromere antibody requires a deeper examination.

Studies like this are important to help build a record of all of the points of contact between these associated conditions so we can begin to understand the intricate web that ties these conditions together, and inch toward the deeper causes that lie at the heart of the mystery of celiac disease, diabetes, and so many other auto-immune/inflammatory disorders.

Source:
Annals of the New York Academy of Sciences - Volume 1173 Issue Contemporary Challenges in Autoimmunity, Pages 633 - 639

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1 Response:

 
Hallie
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said this on
27 Sep 2009 7:36:46 PM PDT
Very interesting. I have DQ8, and though I don't yet have diabetes, nor celiac disease, my anticentromere antibodies are so high they are beyond the ceiling measurable by LabCorp. Off-the-chart-high. Anticentromere antibodies are supposed to be highly associated with scleroderma.




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Hey Palmtrees450, You are not alone. I am going through the exact same thing right now. I thought it was gone but unfortunately I ate something else that has triggered it again. After reading another article on here I am starting to think it is rice...yet one more thing to eliminate from my diet, have already given up dairy and corn, now rice. I have super high anxiety. Doesn't matter who it is or what is said I am over emotional and really struggle in day to day functions even down to just folding a basket of laundry. I do have Xanax but that doesn't even help anymore. I have actually stopped taking it because of that. Only thing that helps is time, rest and drink plenty of water. The rest helps me more because then I get to be still and not think about anything. Hard to function when you have what feels like 15 people in your head at one time talking to you but it is only your thoughts rushing through your mind. I truly hope you feel better soon. Just be cautious out there. Even down to making sure your kitchen is clean and that all of your utensils, plates, pans, etc. are washed extremely well as sometimes I feel like this is where some of my problem comes in at but I haven't figured all of that out yet.

He may need to make a diet change for his diverticulitis. But you can't diagnose Celiac that way. If it were me, I would try another doctor. Is one doesn't sound very good. http://www.cureceliacdisease.org/screening/

This sucks, I want to add to what Knitty Kittty said. We are the Niacin warriors on this board. Here is a long but informative thread that talks about where others' have discussed this topic exhaustively. I also recommend this thread where Knitty Kitty talks about how Niacin helped her itching associated with a DH rash. I hope this is helpful. posterboy,

Yeah I think it has something to do with our overly aggressive immune systems. not gotten virus sick in over 2 years despite being around people who are sick, sorta miss getting sick cause of a virus instead of getting sick cause I ate something that makes me throw up.

How frustrating that they did not do blood tests for celiac! Serpl mcnc is mass concentration in serum or plasma. So as cycling lady said, just checking your immune system.