No popular authors found.
Ads by Google:

Categories

No categories found.


Get Celiac.com's E-Newsletter





Ads by Google:


Follow / Share


  FOLLOW US:
Twitter Facebook Google Plus Pinterest RSS Podcast Email  Get Email Alerts
SHARE:

Popular Articles

No popular articles found.
Celiac.com Sponsors:

Anti-infectious and Autoimmune-associated Autoantibodies in Patients with Type I Diabetes Mellitus and Celiac Disease

Celiac.com 09/24/2009 - Could a reduced level of antibodies against infectious agents indicate a protective role for such infections in T1DM development in susceptible individuals? Recent research points in that direction. Type 1 diabetes mellitus (T1DM) is an autoimmune disease with intricate and poorly understood associations between genetic and environmental factors.

A joint Israeli-Colombian research team recently set out to examine the connections between anti-infectious antibodies and autoimmune-associated autoantibodies in patients with Type I diabetes mellitus and their close family members. Among other things, their findings confirmed a strong association between celiac disease and Type 1 diabetes mellitus.

The research team was made up of Ilan Krause, Juan Manuel Anaya, Abigail Fraser, Ori Barzilai, Maya Ram, Verónica Abad, Alvaro Arango, Jorge García, and Yehuda Shoenfeld. The team compared levels of antibodies to numerous infectious agents and of autoimmune-associated antibodies between Colombian T1DM patients, their close family members and healthy control subjects.

T1DM patients showed substantially reduced levels of antibodies against several infectious agents, including: cytomegalovirus (P= 0.001); Epstein-Barr virus (P= 0.02); Helicobacter pylori (P= 0.01); and Toxoplasma (P= 0.001).

Ads by Google:

T1DM patients showed markedly elevated levels of IgG-anti-gliadin antibodies (P= 0.001) and IgG-antitissue transglutaminase antibodies (P= 0.03), and a marginal connection with anti-centromere antibodies (P= 0.06).

T1DM patients also showed a reduced level of antibodies against infectious agents that may be associated with their younger ages, but could also indicate a protective role for such infections in T1DM development in susceptible individuals.

The results reinforce the connection between T1DM and celiac disease, though the
possible connection with the anti-centromere antibody requires a deeper examination.

Studies like this are important to help build a record of all of the points of contact between these associated conditions so we can begin to understand the intricate web that ties these conditions together, and inch toward the deeper causes that lie at the heart of the mystery of celiac disease, diabetes, and so many other auto-immune/inflammatory disorders.

Source:
Annals of the New York Academy of Sciences - Volume 1173 Issue Contemporary Challenges in Autoimmunity, Pages 633 - 639

Celiac.com welcomes your comments below (registration is NOT required).












Related Articles



1 Response:

 
Hallie
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
27 Sep 2009 7:36:46 PM PDT
Very interesting. I have DQ8, and though I don't yet have diabetes, nor celiac disease, my anticentromere antibodies are so high they are beyond the ceiling measurable by LabCorp. Off-the-chart-high. Anticentromere antibodies are supposed to be highly associated with scleroderma.




Rate this article and leave a comment:
Rating: * Poor Excellent
Your Name *: Email (private) *:




In Celiac.com's Forum Now:


When items have multiple ingredients it can be hard to tell to which we are reacting. That gluten reactions can be delayed can also make it difficult and at times confusing. I would have random reactions at first and keeping a food and symptom diary helped a great deal. For myself the common ite...

They do a breath test, in some cases they can identify it in extreme cases visually if it has spread to the mouth like thrush or viewable on a scope.

Keep a food diary and record everything you eat, condiments, how it is fixed etc. You might have a CC cuplrit and find it this way. Also with this disease it is common to develop random intolerance issues and allergies to foods. If you get glutened depending on your symptoms you can do some thing...

So sorry you are going through this set back. You say you are getting glutened from random uncontrollable cross contamination. What are the things that you think you are getting CC from? Are you consuming oats? If so you may want to drop those for a bit. Are you drinking distilled gluten grain a...

Hi guys, I had a really bad reaction to a certain brand of kefir yesterday. The reaction was neurological and I think it must have been an accidental glutening or an allergic reaction to an additive. The problem is I don?t know which ingredient had caused it. I was wondering if anyone has experie...