No popular authors found.


Get Celiac.com's E-Newsletter

Categories

No categories found.







Ads by Google:


Questions? Join Our Forum:
~1 Million Posts
& Over 66,000 Members!



SHARE THIS PAGE:
Celiac.com Sponsors:

Using HLA Alleles to Stratify Celiac Disease Risk Levels

Celiac.com 10/02/2009 - A team of researchers led by Michelle M. Pietzak, M.D., of the University of Southern California Keck School of Medicine in Los Angeles, recently conducted a large-scale study to identify HLA-DQ haplotypes most connected with increased risk of celiac disease.

Their results show that for people with elevated risk factors for celiac disease, it is in fact possible to stratify risk based on HLA-DQ genotype, according to results of the study published in the September issue of Clinical Gastroenterology and Hepatology.

The research team analyzed blood samples from 10,191 subjects with elevated risk for celiac disease due to clear clinical symptoms, an affected family member, or the presence of other conditions associated with celiac disease.

They found that eight major genotype groups commonly tested positive for anti-endomysial immunoglobulin A. They also noted a steady progression of elevated risk rising from 2.11 percent for DQ8 heterozygotes up to 28.28 percent for DQ2.2+DQ7.5 homozygotes.

Ads by Google:

Additionally, they discovered that the relative risk for anti-endomysial immunoglobulin A positivity of DQ8 homozygous:heterozygous was about the same as DQ2 homozygous:DQ2.5 heterozygous samples, with an odds ratio of about 4.0 for each.

Based on the results, the team concludes that the information might "further quantify the relationship between the expression of celiac disease-associated heterodimers and the occurrence of celiac disease, aid in characterizing previously indeterminate cases, and potentially avoid intestinal biopsies when used in combination with highly sensitive and specific serology."

The add that "targeting these high-risk alleles might aid the design of peptide immuno-therapeutic strategies to augment the gluten-free diet."

Prometheus Laboratories underwrote the study, and all study authors work or consult for the company.

Source:
Clinical Gastroenterology and Hepatology - September, 2009.

Celiac.com welcomes your comments below (registration is NOT required).












Related Articles



1 Response:

 
Nora
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
11 Oct 2009 6:11:17 AM PST
must be a typo here, should be DQ2,2+DQ7,5 in this line: "heterozygotes up to 28.28 percent for DQ2.5/DQ2.2+2.5 homozygotes." (DQ2,2+DQ7,5 together make up trans-DQ2,5)




Rate this article and leave a comment:
Rating: * Poor Excellent
Your Name *: Email (private) *:




In Celiac.com's Forum Now:


It sounds like your hives resolved. I had a six month bout with them. Antihistamines really helped. My doctors are not sure if Mast Cell or autoimmune is the root cause.

My kid has Raynauds. It freaks her classmates out. She wears shoes and wool socks all year round and we live in a warm state. It is autoimmune. She manages it by layering, turning up the heat, use lots of blanket throws. I have Hashimoto?s and celiac disease. So, having multiple autoi...

Well, you do need to replace some things because they are too porous or damaged to remove gluten. Things like old wooden spoons, scratched non-stick pans, toaster, colander, sponges, etc. Honestly, the list is long, so try getting a few celiac books at the library or Amazon. Consider reading t...

When I woke up from my Endoscopy and was told I definitely had celiac disease the first thing I asked my doctor was do I need to get all new kitchen stuff? He assured me that I did not, and as long as my pots and pans and everything else was washed after being used to cook gluten I would have no ...

They have all given you good advice. Like Ennis_Tx said this is not medical advice. Just some observations. Ennis_Tx mentioned already a good B-complex. But people who have Perncious Anemia low B-12 have "Pens and Needles' feeling in their extremities. Mine was much more ...