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Increased Levels of Antigliadin Antibodies not Fully Explained by Intestinal Barrier Gene Variants

Celiac.com 03/05/2010 - A team of researchers recently studied the relationship between increased levels of antigliadin antibodies and intestinal barrier gene variants.

The research team included V. M. Wolters, B. Z. Alizadeh, M. E. Weijerman, A. Zhernakova, I. M. van Hoogstraten, M. L. Mearin, M. C. Wapenaar, C.Wijmenga, M. W. Schreurs. They are affiliated with the Department of Pediatric Gastroenterology, UMC Utrecht, Utrecht, The Netherlands.

Numerous genes may affect intestinal barrier function, including MAGI2, MYO9B, and PARD3, which have a close association with celiac disease. Gauging intestinal permeability is tough to do, so researchers can test indirectly by using antibodies against gliadin and Baker's yeast (anti-Saccharomyces cerevisiae antibodies).

The goal of the study was to determine whether intestinal permeability, represented by antibodies against gliadin, was connected to MAGI2, MYO9B, and PARD3.

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The team analyzed patients with Down syndrome, a population with suspected increased intestinal permeability. The team examined connections between AGA and ASCA.

The team genotyped 126 Down syndrome patients for six single-nucleotide polymorphisms in MAGI2 (rs1496770, rs6962966, rs9640699), MYO9B (rs1457092, rs2305764), and PARD3 (rs10763976).

They then performed an allele dosage association of these risk genes and AGA levels. They also found a strong correlation between AGA and ASCA (p < 0.01).

Subjects with one or more risk genotypes showed lower average AGA levels (trend test p = 0.007) and made up a larger number of patients with normal AGA levels (p = 9.3 x 10(-5)).

Celiac-associated risk genotypes are associated with lower AGA values rather than higher AGA values. This all means that, regarding the increased prevalence of elevated AGA in patients with Down syndrome, there are other immunologic factors at play. These may involve altered induction and/or maintenance of tolerance.

Source:
Hum Immunol. 2010 Feb 3.

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these sound like celiac reactions yes ... basically avoid anything that causes the reaction always and find your self a great natural practitioner and rebuild your body .. Rest vitamins digestive enzymes and very strict diet Good Luck

Hey guys im from the UK and this site is really helpful for me. I've been diagnosed with Coeliac disease (uk spelling) for 5 years now and I slowly became dairy intolerant, which makes sense and I live with this now... but now alcohol has turned on me. I don't drink often and I don't drink a lot (I used to in my uni years) but the reaction the next day (or same night) is horrific. I wondered if anyone else had this problem. I start with sweats and dizziness , then the stomach cramps cause chronic diarrhoea ... I then start to vomit until my body is empty .... this isn't the bad part. After my body is empty I go into a fit like state and cannot move walk talk or anything... the cold sweats start but I'm burning up. The stomach spasms are awful, I have to lie in bed flat with cold wet towels on my head and belly. I cannot speak or move for hours and feel so weak and unstable ..: this lasts all day and I can't eat or drink anything but I don't feel myself for three or four days. I avoid drinking but sometimes it's nice to go out and have some... am I alcohol intolerant??!! Does anyone else have this!? I obviously stick to gluten free drinks and have a very strict diet! Im a severe case! Thankyoy steph

I'm going to contact my primary Dr and see what his take is on this. I know I can't wait another 4 weeks to go to my gastroenterologist. Today marks day 23 of diarrhea. Since switching back to Imodium it has gotten worse. I think that the other 2 medications, even though I couldn't tolerate them and they didn't stop the diarrhea, at least slowed it down a little. If my primary has no clue, then I am definitely contacting U of C. The only thing stopping me is that they are out of network for my insurance plan so it would be more costly.

Spring is cherry blossom season, which means that actual cherries are still far enough off that we'll have to leave their deliciousness ahead, and turn to their canned cousins for this recipe. Turns out, that's not a bad thing. Canned cherries make a tasty cornerstone to this super quick, super-easy no-bake cheesecake. Topped with lovely cherries, this no-bake cheesecake is a contender. Enjoy! View the full article

Haha todays cheat day and I cant decide if i want pizza or mac and cheese lmao oh the struggle.