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Are Celiac Disease and Inflammatory Bowel Disease Related?

Celiac.com 03/24/2010 - Celiac disease is a permanent intolerance to gluten ingestion, which is predisposed in individuals with human leukocyte antigen  (HLA ) and DQ2 or DQ8 haplotype. Celiac is an autoimmune disease and  there has been mounting evidence indicating a substantial connection between celiac and other autoimmune disorders such as, autoimmune thyroiditis and diabetes mellitus type 1.  Additionally, recent evidence has surfaced correlating a relationship between celiac and inflammatory bowel disease (IBD).

An Italian study was designed to research  a gene commonly associated with celiac disease known as MYO IXB, which was recently found to be mutated in IBD patients as well. Additionally, the chromosome 4q27 region is also associated with celiac disease and other autoimmune diseases, and predisposes patients to ulcerative colitis, indicating a common genetic code for these diseases. Although, other IBD risk factors were not found to be candidate genes for celiac disease.

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Italian patients with IBD were tested for celiac disease and their results were lower than expected, and  lower than compared with the general population. celiac disease was found to be more prevalent in patients with ulcerative colitis than in those with Crohn's disease. Ulcerative colitis is typically isolated to the colon and is not present in the small intestine. However, there have been reports of diffuse duodenitis in ulcerative colitis patients which is sometimes mistaken for celiac disease.  The gastroduodenal association with Crohn's disease varies from 30% to 80% of patients.

Celiac disease and inflammatory bowel are not related, they are merely two diseases that sometimes cross the same path. While the prevalence of celiac disease in Italian IBD patients was typically low indicating no close relationship between celiac disease and inflammatory bowl disease, the mutual relationship of these diseases lies in the fact that patients with both conditions frequently share a history of iron-deficient anemia.  It is thus important for patients that are unresponsive to treatments for IBD and are prone to incessant anemia, to also test for celiac disease.


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2 Responses:

 
tmm

said this on
24 Mar 2010 11:58:20 PM PDT
"Permanent intolerance"?
Sounds incredibly understated to those of us who suffered the more insidious aspects of this autoimmune disorder.

 
Kristin Monday
Rating: ratingfullratingfullratingfullratingemptyratingempty Unrated
said this on
31 Aug 2012 8:07:12 AM PDT
The reason both types have anemia is because the parietal cells in the stomach have been destroyed from autoimmune attack, leading to lack of Instrinsic Factor creating an inability to absorb B12 from food, creating pernicious anemia. The question is, does gluten trigger IBD, Crohn's? Gluten triggers allopecia, Hashimoto's, and celiac disease.




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I was wondering if anyone could assist me in sore throat remedies. Cough drops? Teas? I am gargling with salt water but wanted something else. Anything gluten free obviously. Thanks.

Over the last 1.5 years I have had a rash that will not go away. The rash is around the neck, hairline on the front of my head, the back of my scalp, elbows, knees, shins, parts of my ankle, and buttock. The rash seem to get very itchy during the evening. I did have a skin biopsy completed and blood tests last year and they came back negative. I was on oral steroids when I had the test would this possible skew the results? Also its seems the body parts that are exposed to the sun seem to have the rash. Some Pictures http://s1084.photobucket.com/user/Richard_Brandys/library/

Yes the first has wheat gluten in the ingredients, the second via the wheat flour. Here in the UK manufacturers HAVE to highlight gluten sources. Check the ingredients and if WHEAT, BARLEY, or RYE are mentioned *usually highlighted, italicised or underlined, then you will know there's gluten. Most of iceland's processed foods will probably be gluten filled to be honest. Any breadcrumbed or battered foods for instance. Ps, you and me both have another disease, the british one of apologising You don't need to, you're very welcome here and all of your questions are valid and understandable. It's going to get better

Hi, I am deeply sorry for posting on here again. As I am scheduled for an Endoscopy on the 9th May, I wanted to make sure that my gluten intake is being kept the same. I was wondering if the ingredients to these products contain gluten even though dextrose is in one of them? http://groceries.iceland.co.uk/iceland-32-breaded-chicken-nuggets-448g/p/52275 Chicken Breast Fillet (60%), Water, Wheat Flour, Breadcrumbs (Wheat Flour, Dextrose, Salt, Yeast), Rapeseed Oil, Salt, Wheat Gluten, Sugar, Yeast Extract, Garlic Powder, Onion Powder, White Pepper, Dried Sage. http://groceries.iceland.co.uk/iceland-10-breaded-chicken-burgers-550g/p/52276 Chicken Breast Fillet (60%), Water, Wheat Flour, Breadcrumbs (Wheat Flour, Dextrose, Salt, Yeast), Rapeseed Oil, Salt, Wheat Gluten, Sugar, Yeast Extract, Garlic Powder, Onion Powder, White Pepper, Dried Sage. Thank you for all your help so far,

JMG got it down pretty much, the painful and gluten effects from eating it should clear up in a month, damage symptoms you might notice some differences as early as 2-4months but most do not noticed major improvements til about 6 months to a year. I have been gluten-free for over 3 years all my villi have healed according to the doctor on my last scope. It is very important to not cheat and avoid any kind of CC as it can set you back weeks or months. I would suggest a whole foods only diet for the first month or two, no dairy, simple stews, soups, etc. make for easy to digest and simple meals. Check out the 101 thread for some good information. PS a new combo crockpot, steamer, rice cooker combo and liners for a crock pot will be a life saver for making simple meals and easy clean ups. Quick cook microwave ware will also be handy making sure you have gluten-free cooked meals if you can not get new cookware immediately. I normally suggest cleaning out the entire house, scrubbing down knobs, handles, on the drawers, sink, fridge, cubbards etc. throw out condiment jars, checking ingredients on everything in the house including your hygiene and makeup. Putting in drawer organizers for new utensils, throwing out scratched glass, teflon, plastic, and steel cookware. Throwing out any Tupperware, and cutting boards, some utensils that can not be cleaned well. Some times you can save cast iron and stainless steel cook ware if you can run it in your ovens cleaning cycle over 600F. Gluten is a protein like blood if you can not clean a item where a CSI team will not find it give it up, it is not a germ that can be killed with disinfectant. I use freezer paper for clean prep surfaces, also makes clean up a breeze, I tend to use gloves alot also when fixing foods,