No popular authors found.
Ads by Google:

Categories

No categories found.


Get Celiac.com's E-Newsletter





Ads by Google:


Follow / Share


  FOLLOW US:
Twitter Facebook Google Plus Pinterest RSS Podcast Email  Get Email Alerts
SHARE:

Popular Articles

No popular articles found.
Celiac.com Sponsors:

Scientists Claim to Isolate Molecular Trigger for Celiac Disease


New Science Translational Medicine research on celiac trigger

Celiac.com 07/23/2010 - In a breakthrough that may pave the way for the development of the first drug treatments for celiac disease, researchers claim to have identified the molecular triggers for the chronic, painful gut disorder.

Since people with celiac disease must remain gluten-free for life, and since many foods are contaminated with gluten, many people with celiac disease are at risk of developing intestinal damage and other associated problems over time, says Robert Anderson, senior author of the study, and head of the celiac disease research laboratory at the Walter and Eliza Hall Institute of Medical Research in Parkville, Australia.

In Anderson's view, developing a drug that would control the immune response to gluten "would be a much more efficient way of dealing with celiac disease."

However, he adds, a lack of understanding about how gluten triggers the immune system response in celiacs has prevented researchers from pursuing such therapies.

Gluten is actually made-up of numerous different protein strands, and, until now, no one has teased out just which protein strands are inducing the immune response seen in celiac disease.

To design drugs that will effectively treat celiac disease, scientists must first understand exactly which of the gluten molecules are triggering the immune response.

For their study, Anderson and his associates analyzed immune responses in blood samples from more than 200 celiac disease patients who had eaten meals containing gluten.

The team then performed thousands of gluten challenges on the samples using isolated fragments of gluten protein. Interestingly, of the thousands of gluten fragments they tested, only three of them triggered an immune reaction.

That only three of the thousands of protein fragments in gluten provokes an immune response suggests that "a very precise trigger is driving the immune response" in celiac disease, Anderson said. "The problem is not so much gluten, it's really these three peptides."

Ads by Google:

The authors also noted that most of the immune response to gluten appears tied to a single type of immune system cell, called the T cell. Their results appear in the July 21 issue of Science Translational Medicine.

According to Dr. Alessio Fasano of the University of Maryland School of Medicine in Baltimore, even with strong evidence against the three peptides in question, there may be more to the story. It's possible that the study missed other offending protein fragments, and that there are more players in the adverse immune response in people with celiac disease.

Interestingly, sequences from ω-gliadin (wheat) and C-hordein (barley), rather than α-gliadin, proved to be the immunodominant trigger, regardless of the grain consumed.

But before folks with celiac disease get too worked up about a possible cure, they need to remember that, because the study looked at patients with a particular genetic susceptibility to the disease, the findings do not apply to all people with celiac disease.

Although most people with celiac disease share this genetic background, others do not. That means the findings won't apply to everyone with the disease. Anderson and his colleagues are currently working to identify which gluten proteins induce the immune response in the other celiac patients.

The limited diversity of pathogenic T cells in celiac disease indicates that researchers should be able to develop peptide-based treatments for both celiac disease and likely for other HLA-restricted immune diseases.

Phase I clinical trials of a drug based on the three isolated fragments of gluten protein are currently underway in Australia.

Researchers hope the drug will successfully desensitize celiac patients by introducing small amounts of the offending proteins under controlled conditions. They expect results within the next couple of months.

The current study received funding from Nexpep, the Australian National Health and Medical Research Council, Coeliac UK, the Coeliac Research Fund, and others.

Source:


Celiac.com welcomes your comments below (registration is NOT required).












Related Articles



9 Responses:

 
Karin
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
26 Jul 2010 8:13:47 AM PDT
Thanks, this gives my six year old hope:)

 
Maudie wood
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
26 Jul 2010 11:19:30 AM PDT
Can't wait to hear results!

 
Ruth
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
26 Jul 2010 7:06:46 PM PDT
Anyone looking for a cure for celiac disease has my approval.

 
Pam
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
26 Jul 2010 9:08:51 PM PDT
Thank you Jefferson, This was great information to know about, very interesting stuff. I do feel hopeful. I really appreciate your articles and writing style. Again thanks. Sincerely, Pam

 
Gail
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
28 Jul 2010 4:14:55 AM PDT
Very good article on Molecular Triggers
Thank You

 
Jakob
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
29 Jul 2010 2:25:33 PM PDT
Fantastic news, I'm happy to hear that other countries have some serious researchers doing progress. Here in Denmark we feel left behind.
Thanks:)

 
Loretta
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
01 Aug 2010 5:34:14 PM PDT
I am really happy to hear about these trials. I have prayed that a medication could help us celiac patients. Great news.

 
Geeta
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
02 Aug 2010 4:29:07 AM PDT
Thanks, with this article. I am getting hopeful for my nine years old daughter.

 
Geeta
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
10 Aug 2010 8:12:37 PM PDT
Quite hopeful.




Rate this article and leave a comment:
Rating: * Poor Excellent
Your Name *: Email (private) *:




In Celiac.com's Forum Now:


Forum Members, This is a follow up question to a link posted in this thread I have read the Patient Celiac site before but she noted the possible use of Losartan (Potassium) contributing to Villi Blunting? This concerns me because I am now taking Losartan for blood pressure. ...

A few more thoughts. I also join others in saying ditch anything with oats for at least a while, even if they are certified. For hot breakfasts, have quinoa or buckwheat instead.

Oh how awful, and it sounds like there may be a CQ deficit among your medical helpers!, CQ being curiosity quotient. But maybe they?re researching it. It?s very difficult for me, too, to understand when I?ve been glutened ? to narrow down the culprit, or even if there is a culprit. I haven?t...

You've had great suggestions from everyone! Okay, some random thoughts from me. 3 roommates.....wow!.....almost a guarantee of something going wrong daily. They can't be using loose gluten flour, not to make cakes or gravy or anything. Flour hangs in the air for hours to days. What you breat...

Where can I go besides Europe? Anyone know of cool WWOOFing farms that support celiacs? specifically in South America or Asia?